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Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats.
Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E949-57.AJ

Abstract

Rats selectively bred to develop diet-induced obesity (DIO) spontaneously gain more body weight between 5 and 7 wk of age than do those bred to be diet resistant (DR). Here, chow-fed DIO rats ate 9% more and gained 19% more body weight from 5 to 6 wk of age than did DR rats but had comparable leptin and insulin levels. However, 6-wk-old DIO rats had 29% lower plasma ghrelin levels at dark onset but equivalent levels 6 h later compared with DR rats. When subsequently fed a high-energy (HE; 31% fat) diet for 10 days, DIO rats ate 70% more, gained more body and adipose depot weight, had higher leptin and insulin levels, and had 22% lower feed efficiency than DR rats fed HE diet. In DIO rats on HE diet, leptin levels increased significantly at 3 days followed by increased insulin levels at 7 days. These altered DIO leptin and ghrelin responses were associated with 10% lower leptin receptor mRNA expression in the arcuate (ARC), dorsomedial (DMN), and ventromedial hypothalamic nuclei and 13 and 15% lower ghrelin receptor (GHS-R) mRNA expression in the ARC and DMN than in the DR rats. These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role.

Authors+Show Affiliations

Neurology Service, Department of Veterans Affairs Medical Center, 127C VA Medical Center, 385 Tremont Ave., E. Orange, NJ 07018-1095, USA. levin@umdnj.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12865257

Citation

Levin, Barry E., et al. "Abnormalities of Leptin and Ghrelin Regulation in Obesity-prone Juvenile Rats." American Journal of Physiology. Endocrinology and Metabolism, vol. 285, no. 5, 2003, pp. E949-57.
Levin BE, Dunn-Meynell AA, Ricci MR, et al. Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. Am J Physiol Endocrinol Metab. 2003;285(5):E949-57.
Levin, B. E., Dunn-Meynell, A. A., Ricci, M. R., & Cummings, D. E. (2003). Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. American Journal of Physiology. Endocrinology and Metabolism, 285(5), E949-57.
Levin BE, et al. Abnormalities of Leptin and Ghrelin Regulation in Obesity-prone Juvenile Rats. Am J Physiol Endocrinol Metab. 2003;285(5):E949-57. PubMed PMID: 12865257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. AU - Levin,Barry E, AU - Dunn-Meynell,Ambrose A, AU - Ricci,Matt R, AU - Cummings,David E, Y1 - 2003/07/15/ PY - 2003/7/17/pubmed PY - 2003/12/3/medline PY - 2003/7/17/entrez SP - E949 EP - 57 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 285 IS - 5 N2 - Rats selectively bred to develop diet-induced obesity (DIO) spontaneously gain more body weight between 5 and 7 wk of age than do those bred to be diet resistant (DR). Here, chow-fed DIO rats ate 9% more and gained 19% more body weight from 5 to 6 wk of age than did DR rats but had comparable leptin and insulin levels. However, 6-wk-old DIO rats had 29% lower plasma ghrelin levels at dark onset but equivalent levels 6 h later compared with DR rats. When subsequently fed a high-energy (HE; 31% fat) diet for 10 days, DIO rats ate 70% more, gained more body and adipose depot weight, had higher leptin and insulin levels, and had 22% lower feed efficiency than DR rats fed HE diet. In DIO rats on HE diet, leptin levels increased significantly at 3 days followed by increased insulin levels at 7 days. These altered DIO leptin and ghrelin responses were associated with 10% lower leptin receptor mRNA expression in the arcuate (ARC), dorsomedial (DMN), and ventromedial hypothalamic nuclei and 13 and 15% lower ghrelin receptor (GHS-R) mRNA expression in the ARC and DMN than in the DR rats. These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/12865257/Abnormalities_of_leptin_and_ghrelin_regulation_in_obesity_prone_juvenile_rats_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00186.2003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -