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Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala.
Neuropsychopharmacology. 2003 Oct; 28(10):1721-9.N

Abstract

Reinstatement of extinguished drug-seeking behavior following chronic drug self-administration has been demonstrated in rats in the presence of conditioned cues. This experimental model of cue-induced relapse can be used to assess the neural circuitry involved in relapse. We have previously shown that blockade of dopamine D1 receptors in the basolateral amygdala (BLA) abolishes conditioned cue-induced reinstatement of cocaine-seeking behavior. The present study tested the hypothesis that D-amphetamine-induced facilitation of monoamine neurotransmission in the BLA would potentiate conditioned cue-induced reinstatement of extinguished drug-seeking behavior. During daily self-administration sessions over 10 consecutive days, rats pressed a lever to receive cocaine infusions (0.2 mg/0.05 ml) paired with a light+tone compound stimulus. Following self-administration, rats underwent daily extinction sessions, during which no stimuli were presented. On the test days, rats received intra-BLA D-amphetamine (10 or 30 micro g/side) or vehicle infusions followed by extinction or conditioned cue-induced reinstatement testing. D-amphetamine infusions did not alter extinction responding relative to vehicle infusions. During reinstatement testing, conditioned cue presentation significantly increased responding over extinction levels, and intra-BLA D-amphetamine produced a dose-dependent increase in lever responding relative to vehicle infusions. These findings suggest that enhanced monoamine tone in the BLA potentiates the motivational effect and/or salience of cocaine-paired cues during reinstatement.

Authors+Show Affiliations

Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12865896

Citation

Ledford, Christopher C., et al. "Potentiated Reinstatement of Cocaine-seeking Behavior Following D-amphetamine Infusion Into the Basolateral Amygdala." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 28, no. 10, 2003, pp. 1721-9.
Ledford CC, Fuchs RA, See RE. Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala. Neuropsychopharmacology. 2003;28(10):1721-9.
Ledford, C. C., Fuchs, R. A., & See, R. E. (2003). Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 28(10), 1721-9.
Ledford CC, Fuchs RA, See RE. Potentiated Reinstatement of Cocaine-seeking Behavior Following D-amphetamine Infusion Into the Basolateral Amygdala. Neuropsychopharmacology. 2003;28(10):1721-9. PubMed PMID: 12865896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala. AU - Ledford,Christopher C, AU - Fuchs,Rita A, AU - See,Ronald E, PY - 2003/7/17/pubmed PY - 2003/12/6/medline PY - 2003/7/17/entrez SP - 1721 EP - 9 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 28 IS - 10 N2 - Reinstatement of extinguished drug-seeking behavior following chronic drug self-administration has been demonstrated in rats in the presence of conditioned cues. This experimental model of cue-induced relapse can be used to assess the neural circuitry involved in relapse. We have previously shown that blockade of dopamine D1 receptors in the basolateral amygdala (BLA) abolishes conditioned cue-induced reinstatement of cocaine-seeking behavior. The present study tested the hypothesis that D-amphetamine-induced facilitation of monoamine neurotransmission in the BLA would potentiate conditioned cue-induced reinstatement of extinguished drug-seeking behavior. During daily self-administration sessions over 10 consecutive days, rats pressed a lever to receive cocaine infusions (0.2 mg/0.05 ml) paired with a light+tone compound stimulus. Following self-administration, rats underwent daily extinction sessions, during which no stimuli were presented. On the test days, rats received intra-BLA D-amphetamine (10 or 30 micro g/side) or vehicle infusions followed by extinction or conditioned cue-induced reinstatement testing. D-amphetamine infusions did not alter extinction responding relative to vehicle infusions. During reinstatement testing, conditioned cue presentation significantly increased responding over extinction levels, and intra-BLA D-amphetamine produced a dose-dependent increase in lever responding relative to vehicle infusions. These findings suggest that enhanced monoamine tone in the BLA potentiates the motivational effect and/or salience of cocaine-paired cues during reinstatement. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/12865896/Potentiated_reinstatement_of_cocaine_seeking_behavior_following_D_amphetamine_infusion_into_the_basolateral_amygdala_ L2 - https://medlineplus.gov/cocaine.html DB - PRIME DP - Unbound Medicine ER -