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Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?
J Neurosci 2003; 23(15):6304-14JN

Abstract

Previous studies addressing the role of the transcription factor cAMP response element-binding protein (CREB) in mammalian long-term synaptic plasticity and memory by gene targeting were compromised by incomplete deletion of the CREB isoforms. Therefore, we generated conditional knock-out strains with a marked reduction or complete deletion of all CREB isoforms in the hippocampus. In these strains, no deficits could be detected in lasting forms of hippocampal long-term potentiation (LTP) and long-term depression (LTD). When tested for hippocampus-dependent learning, mutants showed normal context-dependent fear conditioning. Water maze learning was impaired during the early stages, but many mutants showed satisfactory scores in probe trials thought to measure hippocampus-dependent spatial memory. However, conditioned taste aversion learning, a putatively hippocampus-independent memory test, was markedly impaired. Our data indicate that in the adult mouse brain, loss of CREB neither prevents learning nor substantially affects performance in some hippocampus-dependent tasks. Furthermore, it spares LTP and LTD in paradigms that are sensitive enough to detect deficits in other mutants. This implies either a species-specific or regionally restricted role of CREB in the brain and/or a compensatory upregulation of the cAMP response element modulator (CREM) and other as yet unidentified transcription factors.

Authors+Show Affiliations

Department of Neurophysiology, Leibniz Institute for Neurobiology, 39108 Magdeburg, Germany. balschun@ifn-magdeburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12867515

Citation

Balschun, Detlef, et al. "Does cAMP Response Element-binding Protein Have a Pivotal Role in Hippocampal Synaptic Plasticity and Hippocampus-dependent Memory?" The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 23, no. 15, 2003, pp. 6304-14.
Balschun D, Wolfer DP, Gass P, et al. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci. 2003;23(15):6304-14.
Balschun, D., Wolfer, D. P., Gass, P., Mantamadiotis, T., Welzl, H., Schütz, G., ... Lipp, H. P. (2003). Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 23(15), pp. 6304-14.
Balschun D, et al. Does cAMP Response Element-binding Protein Have a Pivotal Role in Hippocampal Synaptic Plasticity and Hippocampus-dependent Memory. J Neurosci. 2003 Jul 16;23(15):6304-14. PubMed PMID: 12867515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? AU - Balschun,Detlef, AU - Wolfer,David P, AU - Gass,Peter, AU - Mantamadiotis,Theo, AU - Welzl,Hans, AU - Schütz,Günther, AU - Frey,Julietta U, AU - Lipp,Hans-Peter, PY - 2003/7/18/pubmed PY - 2003/8/14/medline PY - 2003/7/18/entrez SP - 6304 EP - 14 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J. Neurosci. VL - 23 IS - 15 N2 - Previous studies addressing the role of the transcription factor cAMP response element-binding protein (CREB) in mammalian long-term synaptic plasticity and memory by gene targeting were compromised by incomplete deletion of the CREB isoforms. Therefore, we generated conditional knock-out strains with a marked reduction or complete deletion of all CREB isoforms in the hippocampus. In these strains, no deficits could be detected in lasting forms of hippocampal long-term potentiation (LTP) and long-term depression (LTD). When tested for hippocampus-dependent learning, mutants showed normal context-dependent fear conditioning. Water maze learning was impaired during the early stages, but many mutants showed satisfactory scores in probe trials thought to measure hippocampus-dependent spatial memory. However, conditioned taste aversion learning, a putatively hippocampus-independent memory test, was markedly impaired. Our data indicate that in the adult mouse brain, loss of CREB neither prevents learning nor substantially affects performance in some hippocampus-dependent tasks. Furthermore, it spares LTP and LTD in paradigms that are sensitive enough to detect deficits in other mutants. This implies either a species-specific or regionally restricted role of CREB in the brain and/or a compensatory upregulation of the cAMP response element modulator (CREM) and other as yet unidentified transcription factors. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/12867515/Does_cAMP_response_element_binding_protein_have_a_pivotal_role_in_hippocampal_synaptic_plasticity_and_hippocampus_dependent_memory L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=12867515 DB - PRIME DP - Unbound Medicine ER -