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Cigarette smoking and risk of prostate cancer in middle-aged men.
Cancer Epidemiol Biomarkers Prev. 2003 Jul; 12(7):604-9.CE

Abstract

Cigarette smoking may increase the risk of prostate cancer by affecting circulating hormone levels or through exposure to carcinogens. Although there are plausible mechanisms that could explain an association between smoking and prostate cancer, previous studies are inconsistent. The goal of this population-based case-control study was to assess this association in middle-aged men. Cases (n = 753) were men ages 40-64 years diagnosed with prostate cancer from 1993 to 1996 identified using the Seattle-Puget Sound Cancer Registry. Age-matched controls without prostate cancer from the same region (n = 703) were identified using random digit dialing. Participants completed detailed in-person interviews. Logistic regression was used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess the prostate cancer-cigarette smoking relationship. Current smokers had an increased risk (OR = 1.4, 95% CI 1.0-2.0) relative to nonsmokers. A dose-response relationship was noted between number of pack-years smoked and prostate cancer risk (trend P = 0.03). The OR = 1.6 (95% CI 1.1-2.2) for men with >40 pack-years of smoking, with a stronger association observed in men with more aggressive disease (OR = 2.0, 95% CI 1.3-3.1). Smoking cessation resulted in a decline in risk (trend P = 0.02). Smoking is associated with a moderately increased relative risk of prostate cancer. Furthermore, a dose-response relationship exists between number of pack-years smoked and cancer risk. Given that smoking cessation seems to reduce these risks, results from this study have public health ramifications and suggest that prostate cancer should be added to the list of tumors for which cigarette smoking is a risk factor.

Authors+Show Affiliations

Department of Urology, University of Washington, Seattle, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12869398

Citation

Plaskon, Lora A., et al. "Cigarette Smoking and Risk of Prostate Cancer in Middle-aged Men." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 7, 2003, pp. 604-9.
Plaskon LA, Penson DF, Vaughan TL, et al. Cigarette smoking and risk of prostate cancer in middle-aged men. Cancer Epidemiol Biomarkers Prev. 2003;12(7):604-9.
Plaskon, L. A., Penson, D. F., Vaughan, T. L., & Stanford, J. L. (2003). Cigarette smoking and risk of prostate cancer in middle-aged men. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(7), 604-9.
Plaskon LA, et al. Cigarette Smoking and Risk of Prostate Cancer in Middle-aged Men. Cancer Epidemiol Biomarkers Prev. 2003;12(7):604-9. PubMed PMID: 12869398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and risk of prostate cancer in middle-aged men. AU - Plaskon,Lora A, AU - Penson,David F, AU - Vaughan,Thomas L, AU - Stanford,Janet L, PY - 2003/7/19/pubmed PY - 2004/3/26/medline PY - 2003/7/19/entrez SP - 604 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 12 IS - 7 N2 - Cigarette smoking may increase the risk of prostate cancer by affecting circulating hormone levels or through exposure to carcinogens. Although there are plausible mechanisms that could explain an association between smoking and prostate cancer, previous studies are inconsistent. The goal of this population-based case-control study was to assess this association in middle-aged men. Cases (n = 753) were men ages 40-64 years diagnosed with prostate cancer from 1993 to 1996 identified using the Seattle-Puget Sound Cancer Registry. Age-matched controls without prostate cancer from the same region (n = 703) were identified using random digit dialing. Participants completed detailed in-person interviews. Logistic regression was used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess the prostate cancer-cigarette smoking relationship. Current smokers had an increased risk (OR = 1.4, 95% CI 1.0-2.0) relative to nonsmokers. A dose-response relationship was noted between number of pack-years smoked and prostate cancer risk (trend P = 0.03). The OR = 1.6 (95% CI 1.1-2.2) for men with >40 pack-years of smoking, with a stronger association observed in men with more aggressive disease (OR = 2.0, 95% CI 1.3-3.1). Smoking cessation resulted in a decline in risk (trend P = 0.02). Smoking is associated with a moderately increased relative risk of prostate cancer. Furthermore, a dose-response relationship exists between number of pack-years smoked and cancer risk. Given that smoking cessation seems to reduce these risks, results from this study have public health ramifications and suggest that prostate cancer should be added to the list of tumors for which cigarette smoking is a risk factor. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12869398/Cigarette_smoking_and_risk_of_prostate_cancer_in_middle_aged_men_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12869398 DB - PRIME DP - Unbound Medicine ER -