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Soy and isoflavone consumption in relation to prostate cancer risk in China.

Abstract

This case-control study in China evaluated the effect of soy food consumption and isoflavones (genistein and daidzein) on the risk of prostate cancer. One hundred and thirty-three cases and 265 age- and residential community-matched controls between the ages of 50 and 89 years were interviewed in person between 1989 and 1992. Usual consumption of soy foods and isoflavones was assessed using a food frequency questionnaire developed in China and a nutrient database developed and validated in Asian-American populations. The age- and total calorie-adjusted odds ratio (OR) of prostate cancer risk comparing the highest tertile of tofu intake to the lowest tertile was 0.58 [95% confidence interval (CI), 0.35-0.96]. There were also statistically significant associations comparing the highest quartile of intake of soy foods (OR, 0.51; 95% CI, 0.28-0.95) and genistein (OR, 0.53; 95% CI, 0.29-0.97) with the lowest quartiles. There was also an indication of a reduced risk associated with intake of daidzein (OR, 0.56; 95% CI, 0.31-1.04 for the highest versus lowest quartile). Our results indicate a reduced risk of prostate cancer associated with consumption of soy foods and isoflavones. These findings should be confirmed in longitudinal follow-up studies in populations with varying risk of prostate cancer.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, University of California at San Francisco, 94143-0560, USA. mmlee@itsa.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

12869409

Citation

Lee, Marion M., et al. "Soy and Isoflavone Consumption in Relation to Prostate Cancer Risk in China." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 7, 2003, pp. 665-8.
Lee MM, Gomez SL, Chang JS, et al. Soy and isoflavone consumption in relation to prostate cancer risk in China. Cancer Epidemiol Biomarkers Prev. 2003;12(7):665-8.
Lee, M. M., Gomez, S. L., Chang, J. S., Wey, M., Wang, R. T., & Hsing, A. W. (2003). Soy and isoflavone consumption in relation to prostate cancer risk in China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(7), pp. 665-8.
Lee MM, et al. Soy and Isoflavone Consumption in Relation to Prostate Cancer Risk in China. Cancer Epidemiol Biomarkers Prev. 2003;12(7):665-8. PubMed PMID: 12869409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy and isoflavone consumption in relation to prostate cancer risk in China. AU - Lee,Marion M, AU - Gomez,Scarlett Lin, AU - Chang,Jeffrey S, AU - Wey,Mercy, AU - Wang,Run-Tian, AU - Hsing,Ann W, PY - 2003/7/19/pubmed PY - 2004/3/26/medline PY - 2003/7/19/entrez SP - 665 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 7 N2 - This case-control study in China evaluated the effect of soy food consumption and isoflavones (genistein and daidzein) on the risk of prostate cancer. One hundred and thirty-three cases and 265 age- and residential community-matched controls between the ages of 50 and 89 years were interviewed in person between 1989 and 1992. Usual consumption of soy foods and isoflavones was assessed using a food frequency questionnaire developed in China and a nutrient database developed and validated in Asian-American populations. The age- and total calorie-adjusted odds ratio (OR) of prostate cancer risk comparing the highest tertile of tofu intake to the lowest tertile was 0.58 [95% confidence interval (CI), 0.35-0.96]. There were also statistically significant associations comparing the highest quartile of intake of soy foods (OR, 0.51; 95% CI, 0.28-0.95) and genistein (OR, 0.53; 95% CI, 0.29-0.97) with the lowest quartiles. There was also an indication of a reduced risk associated with intake of daidzein (OR, 0.56; 95% CI, 0.31-1.04 for the highest versus lowest quartile). Our results indicate a reduced risk of prostate cancer associated with consumption of soy foods and isoflavones. These findings should be confirmed in longitudinal follow-up studies in populations with varying risk of prostate cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12869409/Soy_and_isoflavone_consumption_in_relation_to_prostate_cancer_risk_in_China_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12869409 DB - PRIME DP - Unbound Medicine ER -