Tags

Type your tag names separated by a space and hit enter

Naturally occurring antioxidant vitamin levels in patients with type-II diabetes mellitus.
J Ayub Med Coll Abbottabad. 2003 Jan-Mar; 15(1):54-7.JA

Abstract

BACKGROUND

Type II diabetes mellitus is characterized by an inability of peripheral tissues to respond to insulin and the dysfunction of the endocrine pancreas to compensate for this resistance. Diabetes mellitus is associated with increased lipid peroxidation. Increased levels of lipid peroxides have been implicated in the pathogenesis of diabetic complications. To control and reduce the deleterious effects of lipid peroxides exist several antioxidant protective mechanisms. They comprise of enzymatic defenses and naturally occurring vitamins. The study was designed to determine and compare the antioxidant vitamin levels in Type II diabetic individuals and control healthy subjects.

METHODS

Blood glucose, triglycerides, total cholesterol, HDL-c, LDL-c, VLDL-c and antioxidant vitamins (beta-Carotene, A, E, and C) levels were determined in 36 Type II diabetic patients and 30 healthy subjects.

RESULTS

Values of blood glucose and lipid parameters were observed to be significantly increased (P < 0.001) with the exception of HDL-c, which was significantly decreased (P < 0.001) in Type II diabetes mellitus patients. The levels of antioxidant vitamins (beta-Carotene, E, and C) were found to be significantly low in Type II diabetes mellitus group whereas the concentration of vitamin A showed a non-significant change when both Type II and control healthy groups were compared.

CONCLUSIONS

Low levels of antioxidant vitamins observed in the study suggest, that Type II diabetes mellitus patients have significant defects of antioxidant protection.

Authors+Show Affiliations

Ahmad M
Department of Chemistry, University of Peshawar, Pakistan.
Khan MA
No affiliation info available
Khan AS
No affiliation info available

MeSH

AdultAgedAntioxidantsBlood GlucoseCase-Control StudiesDiabetes Mellitus, Type 2FemaleHumansLipidsMaleMiddle AgedVitamins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12870320

Citation

Ahmad, Muhammad, et al. "Naturally Occurring Antioxidant Vitamin Levels in Patients With type-II Diabetes Mellitus." Journal of Ayub Medical College, Abbottabad : JAMC, vol. 15, no. 1, 2003, pp. 54-7.
Ahmad M, Khan MA, Khan AS. Naturally occurring antioxidant vitamin levels in patients with type-II diabetes mellitus. J Ayub Med Coll Abbottabad. 2003;15(1):54-7.
Ahmad, M., Khan, M. A., & Khan, A. S. (2003). Naturally occurring antioxidant vitamin levels in patients with type-II diabetes mellitus. Journal of Ayub Medical College, Abbottabad : JAMC, 15(1), 54-7.
Ahmad M, Khan MA, Khan AS. Naturally Occurring Antioxidant Vitamin Levels in Patients With type-II Diabetes Mellitus. J Ayub Med Coll Abbottabad. 2003 Jan-Mar;15(1):54-7. PubMed PMID: 12870320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naturally occurring antioxidant vitamin levels in patients with type-II diabetes mellitus. AU - Ahmad,Muhammad, AU - Khan,Mudassir Ahmad, AU - Khan,Abdus Sattar, PY - 2003/7/23/pubmed PY - 2003/9/11/medline PY - 2003/7/23/entrez SP - 54 EP - 7 JF - Journal of Ayub Medical College, Abbottabad : JAMC JO - J Ayub Med Coll Abbottabad VL - 15 IS - 1 N2 - BACKGROUND: Type II diabetes mellitus is characterized by an inability of peripheral tissues to respond to insulin and the dysfunction of the endocrine pancreas to compensate for this resistance. Diabetes mellitus is associated with increased lipid peroxidation. Increased levels of lipid peroxides have been implicated in the pathogenesis of diabetic complications. To control and reduce the deleterious effects of lipid peroxides exist several antioxidant protective mechanisms. They comprise of enzymatic defenses and naturally occurring vitamins. The study was designed to determine and compare the antioxidant vitamin levels in Type II diabetic individuals and control healthy subjects. METHODS: Blood glucose, triglycerides, total cholesterol, HDL-c, LDL-c, VLDL-c and antioxidant vitamins (beta-Carotene, A, E, and C) levels were determined in 36 Type II diabetic patients and 30 healthy subjects. RESULTS: Values of blood glucose and lipid parameters were observed to be significantly increased (P < 0.001) with the exception of HDL-c, which was significantly decreased (P < 0.001) in Type II diabetes mellitus patients. The levels of antioxidant vitamins (beta-Carotene, E, and C) were found to be significantly low in Type II diabetes mellitus group whereas the concentration of vitamin A showed a non-significant change when both Type II and control healthy groups were compared. CONCLUSIONS: Low levels of antioxidant vitamins observed in the study suggest, that Type II diabetes mellitus patients have significant defects of antioxidant protection. SN - 1025-9589 UR - https://www.unboundmedicine.com/medline/citation/12870320/Naturally_occurring_antioxidant_vitamin_levels_in_patients_with_type_II_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -