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Lyme disease and the peripheral nervous system.
Muscle Nerve. 2003 Aug; 28(2):133-43.MN

Abstract

Lyme disease, the multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex. Diagnosis requires that the patient should have had possible exposure to the only known vectors, Ixodes ticks, and also have either other pathognomonic clinical manifestations or laboratory evidence of exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities.

Authors+Show Affiliations

Department of Neurology, North Shore University Hospital, 300 Community Drive, Manhasset, New York 11030, USA. halperin@nshs.edu

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

12872317

Citation

Halperin, John J.. "Lyme Disease and the Peripheral Nervous System." Muscle & Nerve, vol. 28, no. 2, 2003, pp. 133-43.
Halperin JJ. Lyme disease and the peripheral nervous system. Muscle Nerve. 2003;28(2):133-43.
Halperin, J. J. (2003). Lyme disease and the peripheral nervous system. Muscle & Nerve, 28(2), 133-43.
Halperin JJ. Lyme Disease and the Peripheral Nervous System. Muscle Nerve. 2003;28(2):133-43. PubMed PMID: 12872317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lyme disease and the peripheral nervous system. A1 - Halperin,John J, PY - 2003/7/23/pubmed PY - 2003/8/23/medline PY - 2003/7/23/entrez SP - 133 EP - 43 JF - Muscle & nerve JO - Muscle Nerve VL - 28 IS - 2 N2 - Lyme disease, the multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex. Diagnosis requires that the patient should have had possible exposure to the only known vectors, Ixodes ticks, and also have either other pathognomonic clinical manifestations or laboratory evidence of exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/12872317/Lyme_disease_and_the_peripheral_nervous_system_ L2 - https://doi.org/10.1002/mus.10337 DB - PRIME DP - Unbound Medicine ER -