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Influence of long-term volume therapy with hydroxyethyl starch on leukocytes in patients with acute stroke.
Arzneimittelforschung. 2003; 53(6):402-6.A

Abstract

A repeated administration of hydroxyethyl starch affects hemostasiological and rheological factors such as the concentration of factor VIII/von Willebrand factor, platelet volume and plasma viscosity. An earlier study showed that HES also lowers the concentration of fibronectin, a molecule important in the reticuloendothelial system (RES). RES has a "clearing function" and is a part of the non-immune-specific defense mechanisms of the body. It is involved in the elimination of HES from the blood. Since leukocytes are another important part of the unspecific defense system, the goal of the present study was to investigate whether HES affects leukocytes. After giving their informed consent, 20 patients with cerebral perfusion disorders were randomized and underwent a double-blind 10-day hypervolemic hemodilution with HES 200/0.5/13 or HES 70/0.5/4. The numbers of leukocytes, percentage of lymphocytes, percentage of neutrophilic granulocytes and hemoglobin concentration were measured. The absolute number of leukocytes did not change significantly, but the share of neutrophilic granulocytes increased. The increase in neutrophilic granulocytes reflects an increase in phagocytic activity. HEs 200/0.5/13, which has the larger in vivo molecular weight (MW = 95 kD), caused a larger increase in neutrophilic granulocytes than HES 70/0.5/4, which has an in vivo MW of 58 kD.

Authors+Show Affiliations

Neurologische Klinik, Westpfalz-Klinikum GmbH, Kaiserslautern, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12872610

Citation

Woessner, Ralph, et al. "Influence of Long-term Volume Therapy With Hydroxyethyl Starch On Leukocytes in Patients With Acute Stroke." Arzneimittel-Forschung, vol. 53, no. 6, 2003, pp. 402-6.
Woessner R, Grauer MT, Dieterich HJ, et al. Influence of long-term volume therapy with hydroxyethyl starch on leukocytes in patients with acute stroke. Arzneimittelforschung. 2003;53(6):402-6.
Woessner, R., Grauer, M. T., Dieterich, H. J., Treib, W., Stoll, M., & Treib, J. (2003). Influence of long-term volume therapy with hydroxyethyl starch on leukocytes in patients with acute stroke. Arzneimittel-Forschung, 53(6), 402-6.
Woessner R, et al. Influence of Long-term Volume Therapy With Hydroxyethyl Starch On Leukocytes in Patients With Acute Stroke. Arzneimittelforschung. 2003;53(6):402-6. PubMed PMID: 12872610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of long-term volume therapy with hydroxyethyl starch on leukocytes in patients with acute stroke. AU - Woessner,Ralph, AU - Grauer,Markus T, AU - Dieterich,Hans-Jürgen, AU - Treib,Wolfgang, AU - Stoll,Martin, AU - Treib,Johannes, PY - 2003/7/23/pubmed PY - 2003/8/23/medline PY - 2003/7/23/entrez SP - 402 EP - 6 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 53 IS - 6 N2 - A repeated administration of hydroxyethyl starch affects hemostasiological and rheological factors such as the concentration of factor VIII/von Willebrand factor, platelet volume and plasma viscosity. An earlier study showed that HES also lowers the concentration of fibronectin, a molecule important in the reticuloendothelial system (RES). RES has a "clearing function" and is a part of the non-immune-specific defense mechanisms of the body. It is involved in the elimination of HES from the blood. Since leukocytes are another important part of the unspecific defense system, the goal of the present study was to investigate whether HES affects leukocytes. After giving their informed consent, 20 patients with cerebral perfusion disorders were randomized and underwent a double-blind 10-day hypervolemic hemodilution with HES 200/0.5/13 or HES 70/0.5/4. The numbers of leukocytes, percentage of lymphocytes, percentage of neutrophilic granulocytes and hemoglobin concentration were measured. The absolute number of leukocytes did not change significantly, but the share of neutrophilic granulocytes increased. The increase in neutrophilic granulocytes reflects an increase in phagocytic activity. HEs 200/0.5/13, which has the larger in vivo molecular weight (MW = 95 kD), caused a larger increase in neutrophilic granulocytes than HES 70/0.5/4, which has an in vivo MW of 58 kD. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/12872610/Influence_of_long_term_volume_therapy_with_hydroxyethyl_starch_on_leukocytes_in_patients_with_acute_stroke_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1297127 DB - PRIME DP - Unbound Medicine ER -