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Vitamin C and risk of coronary heart disease in women.

Abstract

OBJECTIVES

Our objective was to prospectively examine the relation between vitamin C intake and risk of coronary heart disease (CHD) in women.

BACKGROUND

Results from prospective investigations of the relation between vitamin C intake and risk of CHD have been inconsistent. The lack of clear evidence for a protective association despite a plausible mechanism indicates the need to evaluate further the association between vitamin C intake and risk of CHD.

METHODS

In 1980, 85,118 female nurses completed a detailed semiquantitative food-frequency questionnaire that assessed their consumption of vitamin C and other nutrients. Nurses were followed up for 16 years for the development of incident CHD (nonfatal myocardial infarction and fatal CHD).

RESULTS

During 16 years of follow-up (1,240,566 person-years), we identified 1,356 incident cases of CHD. After adjustment for age, smoking, and a variety of other coronary risk factors, we observed a modest significant inverse association between total intake of vitamin C and risk of CHD (relative risk [RR] = 0.73; 95% confidence interval [CI] 0.57 to 0.94). Among women who did not use vitamin C supplements or multivitamins, the association between intake of vitamin C from diet alone and incidence of CHD was weak and not significant (RR = 0.86; 95% CI 0.59 to 1.26). In multivariate models adjusting for age, smoking, and a variety of other coronary risk factors, vitamin C supplement use was associated with a significantly lower risk of CHD (RR = 0.72; 95% CI 0.61 to 0.86).

CONCLUSIONS

Users of vitamin C supplements appear to be at lower risk for CHD.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Children's Hospital, Boston, Massachusetts, USA. stavroula.osganian@TCH.harvard.edu

    , , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Antioxidants
    Ascorbic Acid
    Chemoprevention
    Coronary Disease
    Diabetes Complications
    Dietary Supplements
    Female
    Humans
    Hypercholesterolemia
    Hypertension
    Incidence
    Life Style
    Logistic Models
    Middle Aged
    Multivariate Analysis
    Nutrition Surveys
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Smoking
    Surveys and Questionnaires
    United States
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12875759

    Citation

    Osganian, Stavroula K., et al. "Vitamin C and Risk of Coronary Heart Disease in Women." Journal of the American College of Cardiology, vol. 42, no. 2, 2003, pp. 246-52.
    Osganian SK, Stampfer MJ, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol. 2003;42(2):246-52.
    Osganian, S. K., Stampfer, M. J., Rimm, E., Spiegelman, D., Hu, F. B., Manson, J. E., & Willett, W. C. (2003). Vitamin C and risk of coronary heart disease in women. Journal of the American College of Cardiology, 42(2), pp. 246-52.
    Osganian SK, et al. Vitamin C and Risk of Coronary Heart Disease in Women. J Am Coll Cardiol. 2003 Jul 16;42(2):246-52. PubMed PMID: 12875759.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin C and risk of coronary heart disease in women. AU - Osganian,Stavroula K, AU - Stampfer,Meir J, AU - Rimm,Eric, AU - Spiegelman,Donna, AU - Hu,Frank B, AU - Manson,JoAnn E, AU - Willett,Walter C, PY - 2003/7/24/pubmed PY - 2003/8/21/medline PY - 2003/7/24/entrez SP - 246 EP - 52 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 42 IS - 2 N2 - OBJECTIVES: Our objective was to prospectively examine the relation between vitamin C intake and risk of coronary heart disease (CHD) in women. BACKGROUND: Results from prospective investigations of the relation between vitamin C intake and risk of CHD have been inconsistent. The lack of clear evidence for a protective association despite a plausible mechanism indicates the need to evaluate further the association between vitamin C intake and risk of CHD. METHODS: In 1980, 85,118 female nurses completed a detailed semiquantitative food-frequency questionnaire that assessed their consumption of vitamin C and other nutrients. Nurses were followed up for 16 years for the development of incident CHD (nonfatal myocardial infarction and fatal CHD). RESULTS: During 16 years of follow-up (1,240,566 person-years), we identified 1,356 incident cases of CHD. After adjustment for age, smoking, and a variety of other coronary risk factors, we observed a modest significant inverse association between total intake of vitamin C and risk of CHD (relative risk [RR] = 0.73; 95% confidence interval [CI] 0.57 to 0.94). Among women who did not use vitamin C supplements or multivitamins, the association between intake of vitamin C from diet alone and incidence of CHD was weak and not significant (RR = 0.86; 95% CI 0.59 to 1.26). In multivariate models adjusting for age, smoking, and a variety of other coronary risk factors, vitamin C supplement use was associated with a significantly lower risk of CHD (RR = 0.72; 95% CI 0.61 to 0.86). CONCLUSIONS: Users of vitamin C supplements appear to be at lower risk for CHD. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/12875759/Vitamin_C_and_risk_of_coronary_heart_disease_in_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735109703005758 DB - PRIME DP - Unbound Medicine ER -