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High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure.
J Am Coll Cardiol. 2003 Jul 16; 42(2):348-60.JACC

Abstract

OBJECTIVES

The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF).

BACKGROUND

The patterns of activation within the PVs and the VOM during AF in CHF are unclear.

METHODS

We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing.

RESULTS

The duration of induced AF averaged 80.7 +/- 177.3 s. The termination of low-amplitude fractionated activity in the PVs preceded the termination of AF in 25 of 29 episodes. High-density mapping (1-mm resolution) showed that the PV was activated by a focal wave front independent of left atrial (LA) activation in 22 AF episodes. Frequent intra-PV conduction blocks and multiple wave fronts in the PVs were recorded during 10 AF episodes. Focal activations were observed within the VOM in 4 of 12 episodes of AF. Three atrial tachycardia (AT) episodes originated from a focus within a PV. Histological studies showed extensive fibrosis in the PVs and in the atria. The PVs in five normal dogs did not have focal or fractionated activity during induced AF.

CONCLUSIONS

Atrial fibrillation in canine CHF is associated with independent focal activations in the PVs and the VOM, and with complex wave fronts within the PVs. The PVs may also serve as the origin of AT. These findings suggest that electrical and anatomical remodeling of the PVs and the VOM are important in the maintenance of AF and AT in dogs with CHF.

Authors+Show Affiliations

Okuyama Y
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Miyauchi Y
No affiliation info available
Park AM
No affiliation info available
Hamabe A
No affiliation info available
Zhou S
No affiliation info available
Hayashi H
No affiliation info available
Miyauchi M
No affiliation info available
Omichi C
No affiliation info available
Pak HN
No affiliation info available
Brodsky LA
No affiliation info available
Mandel WJ
No affiliation info available
Fishbein MC
No affiliation info available
Karagueuzian HS
No affiliation info available
Chen PS
No affiliation info available

MeSH

Action PotentialsAnimalsAtrial FibrillationCardiac Pacing, ArtificialCatheter AblationCoronary VesselsDisease Models, AnimalDogsElectrocardiographyElectrophysiologic Techniques, CardiacFibrosisHeart AtriaHeart Conduction SystemHeart FailureHeart VentriclesPulmonary VeinsSignal Processing, Computer-Assisted

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12875775

Citation

Okuyama, Yuji, et al. "High Resolution Mapping of the Pulmonary Vein and the Vein of Marshall During Induced Atrial Fibrillation and Atrial Tachycardia in a Canine Model of Pacing-induced Congestive Heart Failure." Journal of the American College of Cardiology, vol. 42, no. 2, 2003, pp. 348-60.
Okuyama Y, Miyauchi Y, Park AM, et al. High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. J Am Coll Cardiol. 2003;42(2):348-60.
Okuyama, Y., Miyauchi, Y., Park, A. M., Hamabe, A., Zhou, S., Hayashi, H., Miyauchi, M., Omichi, C., Pak, H. N., Brodsky, L. A., Mandel, W. J., Fishbein, M. C., Karagueuzian, H. S., & Chen, P. S. (2003). High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. Journal of the American College of Cardiology, 42(2), 348-60.
Okuyama Y, et al. High Resolution Mapping of the Pulmonary Vein and the Vein of Marshall During Induced Atrial Fibrillation and Atrial Tachycardia in a Canine Model of Pacing-induced Congestive Heart Failure. J Am Coll Cardiol. 2003 Jul 16;42(2):348-60. PubMed PMID: 12875775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High resolution mapping of the pulmonary vein and the vein of Marshall during induced atrial fibrillation and atrial tachycardia in a canine model of pacing-induced congestive heart failure. AU - Okuyama,Yuji, AU - Miyauchi,Yasushi, AU - Park,Angela M, AU - Hamabe,Akira, AU - Zhou,Shengmei, AU - Hayashi,Hideki, AU - Miyauchi,Mizuho, AU - Omichi,Chikaya, AU - Pak,Hui Nam, AU - Brodsky,Lauren A, AU - Mandel,William J, AU - Fishbein,Michael C, AU - Karagueuzian,Hrayr S, AU - Chen,Peng Sheng, PY - 2003/7/24/pubmed PY - 2003/8/21/medline PY - 2003/7/24/entrez SP - 348 EP - 60 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 42 IS - 2 N2 - OBJECTIVES: The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF). BACKGROUND: The patterns of activation within the PVs and the VOM during AF in CHF are unclear. METHODS: We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing. RESULTS: The duration of induced AF averaged 80.7 +/- 177.3 s. The termination of low-amplitude fractionated activity in the PVs preceded the termination of AF in 25 of 29 episodes. High-density mapping (1-mm resolution) showed that the PV was activated by a focal wave front independent of left atrial (LA) activation in 22 AF episodes. Frequent intra-PV conduction blocks and multiple wave fronts in the PVs were recorded during 10 AF episodes. Focal activations were observed within the VOM in 4 of 12 episodes of AF. Three atrial tachycardia (AT) episodes originated from a focus within a PV. Histological studies showed extensive fibrosis in the PVs and in the atria. The PVs in five normal dogs did not have focal or fractionated activity during induced AF. CONCLUSIONS: Atrial fibrillation in canine CHF is associated with independent focal activations in the PVs and the VOM, and with complex wave fronts within the PVs. The PVs may also serve as the origin of AT. These findings suggest that electrical and anatomical remodeling of the PVs and the VOM are important in the maintenance of AF and AT in dogs with CHF. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/12875775/High_resolution_mapping_of_the_pulmonary_vein_and_the_vein_of_Marshall_during_induced_atrial_fibrillation_and_atrial_tachycardia_in_a_canine_model_of_pacing_induced_congestive_heart_failure_ DB - PRIME DP - Unbound Medicine ER -