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A retrospective study of 78 patients with severe acute respiratory syndrome.
Chin Med J (Engl). 2003 Jun; 116(6):805-10.CM

Abstract

OBJECTIVE

To summarize the clinical features of severe acute respiratory syndrome (SARS) and to discuss diagnosis and management of the disease.

METHODS

A retrospective study was conducted on 78 cases of SARS referred to the Guangzhou Institute of Respiratory Diseases(GIRD) between December 22, 2002 and near the end of March 2003. Items reviewed cover all data concerning clinical manifestations, laboratory investigation and radiology.

RESULTS

The patients on the study consisted of 42 males and 36 females, aged 20-75 yrs (mean age 37.5 +/- 11.6 yrs), including 44 affected health-care professionals. Clinical symptoms seen in the group were fever (100.0%), cough (88.5%), and dyspnea (79.5%). There were 12 cases (15.3%) with WBCs < 4.0 x 10(9) /L, 49 cases (62.8%) ranging between (4.0 -10.0) x 10(9) /L and 17 cases (21.8%) over 10.0 x 10(9) /L. The average was (7.58 +/- 4.96) x 10(9) /L, with 0.75 +/- 0.14 (neutrophil) and 0.18 +/- 0.11 (lymphocyte). Chest films and CT scanning revealed changes related to pneumonia. The transmission of the disease was likely via close contact with contagious droplets. The prevalences of acute lung injury (ALI, in 37 cases) and acute respiratory distress syndrome (ARDS, 21 out of 37 cases) were considerably high among the patients. Seven patients who developed ARDS complicated with multiple organs dysfunction syndrome (MODS) died.

CONCLUSIONS

A history of close contact, fever, sign of pneumonia by X-ray and normal-to-lowered WBC counts are favorable for the diagnosis of SARS. Recognition of ALI as the important index for critical SARS and comprehensive supportive management are of paramount in decreasing the mortality of the disease.

Authors+Show Affiliations

Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12877784

Citation

Xiao, Zhenglun, et al. "A Retrospective Study of 78 Patients With Severe Acute Respiratory Syndrome." Chinese Medical Journal, vol. 116, no. 6, 2003, pp. 805-10.
Xiao Z, Li Y, Chen R, et al. A retrospective study of 78 patients with severe acute respiratory syndrome. Chin Med J (Engl). 2003;116(6):805-10.
Xiao, Z., Li, Y., Chen, R., Li, S., Zhong, S., & Zhong, N. (2003). A retrospective study of 78 patients with severe acute respiratory syndrome. Chinese Medical Journal, 116(6), 805-10.
Xiao Z, et al. A Retrospective Study of 78 Patients With Severe Acute Respiratory Syndrome. Chin Med J (Engl). 2003;116(6):805-10. PubMed PMID: 12877784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A retrospective study of 78 patients with severe acute respiratory syndrome. AU - Xiao,Zhenglun, AU - Li,Yimin, AU - Chen,Rongchang, AU - Li,Shiyue, AU - Zhong,Shuqing, AU - Zhong,Nanshan, PY - 2003/7/25/pubmed PY - 2003/10/24/medline PY - 2003/7/25/entrez SP - 805 EP - 10 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 116 IS - 6 N2 - OBJECTIVE: To summarize the clinical features of severe acute respiratory syndrome (SARS) and to discuss diagnosis and management of the disease. METHODS: A retrospective study was conducted on 78 cases of SARS referred to the Guangzhou Institute of Respiratory Diseases(GIRD) between December 22, 2002 and near the end of March 2003. Items reviewed cover all data concerning clinical manifestations, laboratory investigation and radiology. RESULTS: The patients on the study consisted of 42 males and 36 females, aged 20-75 yrs (mean age 37.5 +/- 11.6 yrs), including 44 affected health-care professionals. Clinical symptoms seen in the group were fever (100.0%), cough (88.5%), and dyspnea (79.5%). There were 12 cases (15.3%) with WBCs < 4.0 x 10(9) /L, 49 cases (62.8%) ranging between (4.0 -10.0) x 10(9) /L and 17 cases (21.8%) over 10.0 x 10(9) /L. The average was (7.58 +/- 4.96) x 10(9) /L, with 0.75 +/- 0.14 (neutrophil) and 0.18 +/- 0.11 (lymphocyte). Chest films and CT scanning revealed changes related to pneumonia. The transmission of the disease was likely via close contact with contagious droplets. The prevalences of acute lung injury (ALI, in 37 cases) and acute respiratory distress syndrome (ARDS, 21 out of 37 cases) were considerably high among the patients. Seven patients who developed ARDS complicated with multiple organs dysfunction syndrome (MODS) died. CONCLUSIONS: A history of close contact, fever, sign of pneumonia by X-ray and normal-to-lowered WBC counts are favorable for the diagnosis of SARS. Recognition of ALI as the important index for critical SARS and comprehensive supportive management are of paramount in decreasing the mortality of the disease. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/12877784/A_retrospective_study_of_78_patients_with_severe_acute_respiratory_syndrome_ DB - PRIME DP - Unbound Medicine ER -