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Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance.
Chin Med J (Engl). 2003 Jun; 116(6):827-30.CM

Abstract

OBJECTIVE

To investigate the changes of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome (SARS) and its clinical significance.

METHODS

Subgroups of blood T lymphocytes in 93 patients with SARS were detected by flow cytometer. The results detected in 64 normal subjects and 50 patients with AIDS served as controls.

RESULTS

The numbers of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes all significantly decreased in acute phase of patients with SARS [(722 +/- 533)/microliter, (438 +/- 353)/microliter, (307 +/- 217)/microliter] compared with those in normal controls [(1527 +/- 470)/microliter, (787 +/- 257)/microliter, (633 +/- 280)/microliter, all P <0.01], which was different from what we observed in patients with AIDS who had decreased CD(4)(+) [(296 +/- 298)/microliter] but increased CD(8)(+) [(818 +/- 566)/microliter] counts. The counts of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes decreased more apparently in patients with severe SARS. All the five patients who died had CD(4)(+) counts less than 200/microliter. As the patients' condition improved, CD(3)(+), CD(4)(+), and CD(8)(+) counts gradually returned to normal ranges.

CONCLUSION

The damage of cellular immunity is probably an important mechanism of pathogenesis of SARS.

Authors+Show Affiliations

Department of Infectious Diseases, Guangzhou No.8 People's Hospital, Guangzhou 510060, P. R. China. xtang@21cn.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12877788

Citation

Tang, Xiaoping, et al. "Measurement of Subgroups of Peripheral Blood T Lymphocytes in Patients With Severe Acute Respiratory Syndrome and Its Clinical Significance." Chinese Medical Journal, vol. 116, no. 6, 2003, pp. 827-30.
Tang X, Yin C, Zhang F, et al. Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance. Chin Med J (Engl). 2003;116(6):827-30.
Tang, X., Yin, C., Zhang, F., Fu, Y., Chen, W., Chen, Y., Wang, J., Jia, W., & Xu, A. (2003). Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance. Chinese Medical Journal, 116(6), 827-30.
Tang X, et al. Measurement of Subgroups of Peripheral Blood T Lymphocytes in Patients With Severe Acute Respiratory Syndrome and Its Clinical Significance. Chin Med J (Engl). 2003;116(6):827-30. PubMed PMID: 12877788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance. AU - Tang,Xiaoping, AU - Yin,Chibiao, AU - Zhang,Fuchun, AU - Fu,Yonggui, AU - Chen,Weilie, AU - Chen,Yanqing, AU - Wang,Jian, AU - Jia,Weidong, AU - Xu,Anlong, PY - 2003/7/25/pubmed PY - 2003/10/24/medline PY - 2003/7/25/entrez SP - 827 EP - 30 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 116 IS - 6 N2 - OBJECTIVE: To investigate the changes of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome (SARS) and its clinical significance. METHODS: Subgroups of blood T lymphocytes in 93 patients with SARS were detected by flow cytometer. The results detected in 64 normal subjects and 50 patients with AIDS served as controls. RESULTS: The numbers of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes all significantly decreased in acute phase of patients with SARS [(722 +/- 533)/microliter, (438 +/- 353)/microliter, (307 +/- 217)/microliter] compared with those in normal controls [(1527 +/- 470)/microliter, (787 +/- 257)/microliter, (633 +/- 280)/microliter, all P <0.01], which was different from what we observed in patients with AIDS who had decreased CD(4)(+) [(296 +/- 298)/microliter] but increased CD(8)(+) [(818 +/- 566)/microliter] counts. The counts of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes decreased more apparently in patients with severe SARS. All the five patients who died had CD(4)(+) counts less than 200/microliter. As the patients' condition improved, CD(3)(+), CD(4)(+), and CD(8)(+) counts gradually returned to normal ranges. CONCLUSION: The damage of cellular immunity is probably an important mechanism of pathogenesis of SARS. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/12877788/Measurement_of_subgroups_of_peripheral_blood_T_lymphocytes_in_patients_with_severe_acute_respiratory_syndrome_and_its_clinical_significance_ L2 - https://antibodies.cancer.gov/detail/CPTC-CD4-1 DB - PRIME DP - Unbound Medicine ER -