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The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies.
Eur J Clin Nutr 2003; 57(8):904-8EJ

Abstract

OBJECTIVE

To assess the association of dietary flavonol intake with the subsequent risk of coronary heart disease (CHD) mortality.

DESIGN

Meta-analysis of prospective cohort studies published before September 2001. Studies were identified by MEDLINE and EMBASE searches and by scanning relevant reference lists. The following information was extracted from published reports: size of cohort, mean age, mean duration of follow-up, number of fatal CHD events, mean flavonol intake, main sources of flavonol intake, degree of adjustment for potential confounders, and the relation of CHD mortality to dietary flavonol intake measured at baseline.

RESULTS

Seven prospective cohorts of men and women were identified including a total of 2087 fatal CHD events. Comparison of individuals in the top third with those in the bottom third of dietary flavonol intake yielded a combined risk ratio of 0.80 (95% CI 0.69-0.93) after adjustment for known CHD risk factors and other dietary components.

CONCLUSION

This overview of prospective cohort studies indicates that high dietary intake of flavonols from a small number of fruits and vegetables, tea and red wine may be associated with a reduced risk from CHD mortality in free-living populations.

Authors+Show Affiliations

Institute for International Health, University of Sydney, Australia. rhuxlet@iih.usyd.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12879084

Citation

Huxley, R R., and H A W. Neil. "The Relation Between Dietary Flavonol Intake and Coronary Heart Disease Mortality: a Meta-analysis of Prospective Cohort Studies." European Journal of Clinical Nutrition, vol. 57, no. 8, 2003, pp. 904-8.
Huxley RR, Neil HA. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2003;57(8):904-8.
Huxley, R. R., & Neil, H. A. (2003). The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. European Journal of Clinical Nutrition, 57(8), pp. 904-8.
Huxley RR, Neil HA. The Relation Between Dietary Flavonol Intake and Coronary Heart Disease Mortality: a Meta-analysis of Prospective Cohort Studies. Eur J Clin Nutr. 2003;57(8):904-8. PubMed PMID: 12879084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. AU - Huxley,R R, AU - Neil,H A W, PY - 2003/7/25/pubmed PY - 2003/12/19/medline PY - 2003/7/25/entrez SP - 904 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 8 N2 - OBJECTIVE: To assess the association of dietary flavonol intake with the subsequent risk of coronary heart disease (CHD) mortality. DESIGN: Meta-analysis of prospective cohort studies published before September 2001. Studies were identified by MEDLINE and EMBASE searches and by scanning relevant reference lists. The following information was extracted from published reports: size of cohort, mean age, mean duration of follow-up, number of fatal CHD events, mean flavonol intake, main sources of flavonol intake, degree of adjustment for potential confounders, and the relation of CHD mortality to dietary flavonol intake measured at baseline. RESULTS: Seven prospective cohorts of men and women were identified including a total of 2087 fatal CHD events. Comparison of individuals in the top third with those in the bottom third of dietary flavonol intake yielded a combined risk ratio of 0.80 (95% CI 0.69-0.93) after adjustment for known CHD risk factors and other dietary components. CONCLUSION: This overview of prospective cohort studies indicates that high dietary intake of flavonols from a small number of fruits and vegetables, tea and red wine may be associated with a reduced risk from CHD mortality in free-living populations. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12879084/The_relation_between_dietary_flavonol_intake_and_coronary_heart_disease_mortality:_a_meta_analysis_of_prospective_cohort_studies_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601624 DB - PRIME DP - Unbound Medicine ER -