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Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis.
Eur J Clin Nutr. 2003 Aug; 57(8):940-6.EJ

Abstract

BACKGROUND

Differences in isoflavone content of soy protein may explain the absence of a dose-response relation between soy protein intake and blood cholesterol concentrations.

OBJECTIVE

To study specifically the effect of soy-associated isoflavones on cholesterol concentrations in well-controlled trials substituting soy protein with dairy or animal protein.

DESIGN

Studies were identified by MEDLINE searches (1995 - 6 June 2002) and reviewing reference lists. Studies were included if they had a control group or treatment, experimental diets only differed in the amounts of soy protein and isoflavones and were each fed for at least 14 days. A total of 10 studies met these criteria, providing 21 dietary comparisons.

SUBJECTS

: Studies comprised 959 subjects (336 men and 623 women), average age ranged from 41 to 67 y and baseline cholesterol concentration from 5.42 to 6.60 mmol/l.

INTERVENTIONS

The intake of soy-associated isoflavones increased by 1-95 mg/day and the intake of soy protein increased by 19-60 g/day.

RESULTS

Feeding daily 36 g soy protein with 52 mg soy-associated isoflavones on average decreased low-density lipoprotein (LDL) cholesterol by -0.17+/-0.04 mmol/l (mean+/-s.e.) and increased high-density lipoprotein (HDL) cholesterol by 0.03+/-0.01 mmol/l. There was no dose-response relation between soy-associated isoflavones and changes in LDL cholesterol (R=-0.33, P=0.14) (Pearson correlation coefficient) or HDL cholesterol (R=-0.07, P=0.76) or their ratio.

CONCLUSIONS

Consumption of soy-associated isoflavones is not related to changes in LDL or HDL cholesterol.

Authors+Show Affiliations

Unilever Health Institute, Unilever Research and Development Vlaardingen, Vlaardingen, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12879088

Citation

Weggemans, R M., and E A. Trautwein. "Relation Between Soy-associated Isoflavones and LDL and HDL Cholesterol Concentrations in Humans: a Meta-analysis." European Journal of Clinical Nutrition, vol. 57, no. 8, 2003, pp. 940-6.
Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. Eur J Clin Nutr. 2003;57(8):940-6.
Weggemans, R. M., & Trautwein, E. A. (2003). Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. European Journal of Clinical Nutrition, 57(8), 940-6.
Weggemans RM, Trautwein EA. Relation Between Soy-associated Isoflavones and LDL and HDL Cholesterol Concentrations in Humans: a Meta-analysis. Eur J Clin Nutr. 2003;57(8):940-6. PubMed PMID: 12879088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. AU - Weggemans,R M, AU - Trautwein,E A, PY - 2003/7/25/pubmed PY - 2003/12/19/medline PY - 2003/7/25/entrez SP - 940 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 8 N2 - BACKGROUND: Differences in isoflavone content of soy protein may explain the absence of a dose-response relation between soy protein intake and blood cholesterol concentrations. OBJECTIVE: To study specifically the effect of soy-associated isoflavones on cholesterol concentrations in well-controlled trials substituting soy protein with dairy or animal protein. DESIGN: Studies were identified by MEDLINE searches (1995 - 6 June 2002) and reviewing reference lists. Studies were included if they had a control group or treatment, experimental diets only differed in the amounts of soy protein and isoflavones and were each fed for at least 14 days. A total of 10 studies met these criteria, providing 21 dietary comparisons. SUBJECTS: : Studies comprised 959 subjects (336 men and 623 women), average age ranged from 41 to 67 y and baseline cholesterol concentration from 5.42 to 6.60 mmol/l. INTERVENTIONS: The intake of soy-associated isoflavones increased by 1-95 mg/day and the intake of soy protein increased by 19-60 g/day. RESULTS: Feeding daily 36 g soy protein with 52 mg soy-associated isoflavones on average decreased low-density lipoprotein (LDL) cholesterol by -0.17+/-0.04 mmol/l (mean+/-s.e.) and increased high-density lipoprotein (HDL) cholesterol by 0.03+/-0.01 mmol/l. There was no dose-response relation between soy-associated isoflavones and changes in LDL cholesterol (R=-0.33, P=0.14) (Pearson correlation coefficient) or HDL cholesterol (R=-0.07, P=0.76) or their ratio. CONCLUSIONS: Consumption of soy-associated isoflavones is not related to changes in LDL or HDL cholesterol. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12879088/Relation_between_soy_associated_isoflavones_and_LDL_and_HDL_cholesterol_concentrations_in_humans:_a_meta_analysis_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601628 DB - PRIME DP - Unbound Medicine ER -