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Oxidative stress status in patients with diabetes mellitus: relationship to diet.
Eur J Clin Nutr. 2003 Aug; 57(8):999-1008.EJ

Abstract

OBJECTIVE

To investigate the relationship between dietary intakes and in vivo oxidative stress (OS) status in diabetic patients.

DESIGN

Case-control study.

SETTING

Outpatient-Clinic and Laboratory Endocrinology, University Antwerp.

SUBJECTS AND METHODS

A total of 30 patients (24 type 1 diabetes mellitus (T1DM)/6 type 2 diabetes mellitus (T2DM) were asked to complete a 2 weekdays+1 weekend day food consumption questionnaire during the week preceding their yearly diabetes control consultation, when samples were collected for the assay of oxidative stress (OS) (blood levels of antioxidants, peroxides, malondialdehyde (MDA) and minerals). Blood samples were also collected from 25 age- and sex-matched healthy controls.

RESULTS

Diabetic patients had lower glutathione (5.80+/-1.15 vs 6.75+/-1.03 micromol/g Hb in the controls, P=0.002) and higher MDA (0.687+/-0.212 vs 0.545+/-0.101 micromol/l, P=0.002). Although the group average intakes were within the Belgian RDA, intakes of fat >35% energy, fibre <15 g/1000 kcal, fruit <2 portions and vitamin E <10 mg/day were seen in more than 20 patients. Blood antioxidants did not correlate with intakes of energy, fat, protein or fibres or of their respective antioxidant. Vitamins A and E correlated with serum lipids (r=0.58, P <0.0005 between serum alpha-tocopherol and cholesterol). Blood peroxide levels were only related to intakes of saturated fat and cholesterol (P<0.05). In diabetic subjects but not in controls (P<0.05) MDA was related to glutathione and uric acid.

CONCLUSIONS

In diabetic patients, blood levels of antioxidants are not related to their dietary intakes but to serum lipids. Levels of oxidative damage products are only related to intakes of saturated fats and cholesterol and to levels of endogenous antioxidants.

Authors+Show Affiliations

Laboratory of Endocrinology, University of Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12879095

Citation

Dierckx, N, et al. "Oxidative Stress Status in Patients With Diabetes Mellitus: Relationship to Diet." European Journal of Clinical Nutrition, vol. 57, no. 8, 2003, pp. 999-1008.
Dierckx N, Horvath G, van Gils C, et al. Oxidative stress status in patients with diabetes mellitus: relationship to diet. Eur J Clin Nutr. 2003;57(8):999-1008.
Dierckx, N., Horvath, G., van Gils, C., Vertommen, J., van de Vliet, J., De Leeuw, I., & Manuel-y-Keenoy, B. (2003). Oxidative stress status in patients with diabetes mellitus: relationship to diet. European Journal of Clinical Nutrition, 57(8), 999-1008.
Dierckx N, et al. Oxidative Stress Status in Patients With Diabetes Mellitus: Relationship to Diet. Eur J Clin Nutr. 2003;57(8):999-1008. PubMed PMID: 12879095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress status in patients with diabetes mellitus: relationship to diet. AU - Dierckx,N, AU - Horvath,G, AU - van Gils,C, AU - Vertommen,J, AU - van de Vliet,J, AU - De Leeuw,I, AU - Manuel-y-Keenoy,B, PY - 2003/7/25/pubmed PY - 2003/12/19/medline PY - 2003/7/25/entrez SP - 999 EP - 1008 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 8 N2 - OBJECTIVE: To investigate the relationship between dietary intakes and in vivo oxidative stress (OS) status in diabetic patients. DESIGN: Case-control study. SETTING: Outpatient-Clinic and Laboratory Endocrinology, University Antwerp. SUBJECTS AND METHODS: A total of 30 patients (24 type 1 diabetes mellitus (T1DM)/6 type 2 diabetes mellitus (T2DM) were asked to complete a 2 weekdays+1 weekend day food consumption questionnaire during the week preceding their yearly diabetes control consultation, when samples were collected for the assay of oxidative stress (OS) (blood levels of antioxidants, peroxides, malondialdehyde (MDA) and minerals). Blood samples were also collected from 25 age- and sex-matched healthy controls. RESULTS: Diabetic patients had lower glutathione (5.80+/-1.15 vs 6.75+/-1.03 micromol/g Hb in the controls, P=0.002) and higher MDA (0.687+/-0.212 vs 0.545+/-0.101 micromol/l, P=0.002). Although the group average intakes were within the Belgian RDA, intakes of fat >35% energy, fibre <15 g/1000 kcal, fruit <2 portions and vitamin E <10 mg/day were seen in more than 20 patients. Blood antioxidants did not correlate with intakes of energy, fat, protein or fibres or of their respective antioxidant. Vitamins A and E correlated with serum lipids (r=0.58, P <0.0005 between serum alpha-tocopherol and cholesterol). Blood peroxide levels were only related to intakes of saturated fat and cholesterol (P<0.05). In diabetic subjects but not in controls (P<0.05) MDA was related to glutathione and uric acid. CONCLUSIONS: In diabetic patients, blood levels of antioxidants are not related to their dietary intakes but to serum lipids. Levels of oxidative damage products are only related to intakes of saturated fats and cholesterol and to levels of endogenous antioxidants. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12879095/Oxidative_stress_status_in_patients_with_diabetes_mellitus:_relationship_to_diet_ L2 - https://doi.org/10.1038/sj.ejcn.1601635 DB - PRIME DP - Unbound Medicine ER -