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Aerobic and anaerobic ethanol production by Mucor circinelloides during submerged growth.
Appl Microbiol Biotechnol. 2004 Feb; 63(5):543-8.AM

Abstract

The dimorphic organism Mucor circinelloides is currently being investigated as a potential host for heterologous protein production. The production of ethanol on pentose and hexose sugars was studied in submerged batch cultivations to further the general knowledge of Mucor physiology, with a view to the minimisation or elimination of the by-product ethanol for future process design. Large amounts of ethanol were produced during aerobic growth on glucose under non-oxygen limiting conditions, which is indicative of M. circinelloides being a Crabtree-positive organism. Ethanol production on galactose or xylose was less significant. The response of the organism to increased ethanol concentrations, both as the sole carbon source and in the presence of a sugar, was investigated in terms of biomass formation and morphology.

Authors+Show Affiliations

Lübbehüsen TL
Center for Process Biotechnology, BioCentrum-DTU, Technical University of Denmark, Building 223, 2800 Kgs. Lyngby, Denmark.
Nielsen J
No affiliation info available
McIntyre M
No affiliation info available

MeSH

AerobiosisAirAnaerobiosisBiomassBioreactorsCarbon DioxideCulture MediaEthanolFermentationGlucoseHyphaeIndustrial MicrobiologyKineticsMucorNitrogenTime FactorsXylose

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12879305

Citation

Lübbehüsen, T L., et al. "Aerobic and Anaerobic Ethanol Production By Mucor Circinelloides During Submerged Growth." Applied Microbiology and Biotechnology, vol. 63, no. 5, 2004, pp. 543-8.
Lübbehüsen TL, Nielsen J, McIntyre M. Aerobic and anaerobic ethanol production by Mucor circinelloides during submerged growth. Appl Microbiol Biotechnol. 2004;63(5):543-8.
Lübbehüsen, T. L., Nielsen, J., & McIntyre, M. (2004). Aerobic and anaerobic ethanol production by Mucor circinelloides during submerged growth. Applied Microbiology and Biotechnology, 63(5), 543-8.
Lübbehüsen TL, Nielsen J, McIntyre M. Aerobic and Anaerobic Ethanol Production By Mucor Circinelloides During Submerged Growth. Appl Microbiol Biotechnol. 2004;63(5):543-8. PubMed PMID: 12879305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerobic and anaerobic ethanol production by Mucor circinelloides during submerged growth. AU - Lübbehüsen,T L, AU - Nielsen,J, AU - McIntyre,M, Y1 - 2003/07/16/ PY - 2003/02/10/received PY - 2003/06/10/revised PY - 2003/06/14/accepted PY - 2003/7/25/pubmed PY - 2004/4/15/medline PY - 2003/7/25/entrez SP - 543 EP - 8 JF - Applied microbiology and biotechnology JO - Appl Microbiol Biotechnol VL - 63 IS - 5 N2 - The dimorphic organism Mucor circinelloides is currently being investigated as a potential host for heterologous protein production. The production of ethanol on pentose and hexose sugars was studied in submerged batch cultivations to further the general knowledge of Mucor physiology, with a view to the minimisation or elimination of the by-product ethanol for future process design. Large amounts of ethanol were produced during aerobic growth on glucose under non-oxygen limiting conditions, which is indicative of M. circinelloides being a Crabtree-positive organism. Ethanol production on galactose or xylose was less significant. The response of the organism to increased ethanol concentrations, both as the sole carbon source and in the presence of a sugar, was investigated in terms of biomass formation and morphology. SN - 0175-7598 UR - https://www.unboundmedicine.com/medline/citation/12879305/Aerobic_and_anaerobic_ethanol_production_by_Mucor_circinelloides_during_submerged_growth_ DB - PRIME DP - Unbound Medicine ER -