Tags

Type your tag names separated by a space and hit enter

Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India.
Ann Clin Biochem. 2003 Jul; 40(Pt 4):382-7.AC

Abstract

OBJECTIVES

Several factors, including abdominal obesity, insulin resistance, diabetes mellitus and low levels of high-density lipoprotein cholesterol have been implicated in the high prevalence and early onset of coronary heart disease in Asian Indians. However, there are no reports regarding the role of apolipoprotein E (apo E) gene polymorphisms in premature myocardial infarction (MI) in this population. This study aimed to study the role of apo E gene polymorphisms in premature MI patients and their relation to serum lipid levels.

DESIGN AND METHODS

Apo E gene polymorphisms were analysed in 35 patients with MI aged <40 years and in 45 age- and sex-matched controls using polymerase chain reaction-restriction fragment length polymorphism. Levels of serum lipids were measured in addition to the evaluation of conventional risk factors.

RESULTS

Higher frequencies of the apo E4 allele (P<0.0001) and of genotypes E3/E4 (P<0.005) and E4/E4 (P<0.005) were recorded in the premature MI group compared with the controls. Multivariate regression analysis revealed that, after adjusting for other covariates, individuals with the E4 allele were at ~46 times higher odds to develop premature MI compared with individuals without the E4 allele [adjusted odds ratio, OR (95% confidence interval, CI): 45.7 (4.9-421.3)]. Among conventional risk factors, higher risk was observed in those having dyslipidaemia [OR (95% CI): 8.7 (0.9-86.6)] and those with a high waist : hip ratio [OR (95% CI): 5.6 (1.4-21.2)].

CONCLUSION

Based on the robust association, the apo E4 allele should be considered as an independent risk factor for premature MI in Asian Indians.

Authors+Show Affiliations

Department of Medicine, All India Institute of Medical Sciences, New Delhi-110 029, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12880539

Citation

Kumar, Prabhat, et al. "Apolipoprotein E Gene Polymorphisms in Patients With Premature Myocardial Infarction: a Case-controlled Study in Asian Indians in North India." Annals of Clinical Biochemistry, vol. 40, no. Pt 4, 2003, pp. 382-7.
Kumar P, Luthra K, Dwivedi M, et al. Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India. Ann Clin Biochem. 2003;40(Pt 4):382-7.
Kumar, P., Luthra, K., Dwivedi, M., Behl, V. K., Pandey, R. M., & Misra, A. (2003). Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India. Annals of Clinical Biochemistry, 40(Pt 4), 382-7.
Kumar P, et al. Apolipoprotein E Gene Polymorphisms in Patients With Premature Myocardial Infarction: a Case-controlled Study in Asian Indians in North India. Ann Clin Biochem. 2003;40(Pt 4):382-7. PubMed PMID: 12880539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene polymorphisms in patients with premature myocardial infarction: a case-controlled study in Asian Indians in North India. AU - Kumar,Prabhat, AU - Luthra,Kalpana, AU - Dwivedi,Manjari, AU - Behl,Vinay K, AU - Pandey,Ravinder M, AU - Misra,Anoop, PY - 2003/7/26/pubmed PY - 2004/2/21/medline PY - 2003/7/26/entrez SP - 382 EP - 7 JF - Annals of clinical biochemistry JO - Ann Clin Biochem VL - 40 IS - Pt 4 N2 - OBJECTIVES: Several factors, including abdominal obesity, insulin resistance, diabetes mellitus and low levels of high-density lipoprotein cholesterol have been implicated in the high prevalence and early onset of coronary heart disease in Asian Indians. However, there are no reports regarding the role of apolipoprotein E (apo E) gene polymorphisms in premature myocardial infarction (MI) in this population. This study aimed to study the role of apo E gene polymorphisms in premature MI patients and their relation to serum lipid levels. DESIGN AND METHODS: Apo E gene polymorphisms were analysed in 35 patients with MI aged <40 years and in 45 age- and sex-matched controls using polymerase chain reaction-restriction fragment length polymorphism. Levels of serum lipids were measured in addition to the evaluation of conventional risk factors. RESULTS: Higher frequencies of the apo E4 allele (P<0.0001) and of genotypes E3/E4 (P<0.005) and E4/E4 (P<0.005) were recorded in the premature MI group compared with the controls. Multivariate regression analysis revealed that, after adjusting for other covariates, individuals with the E4 allele were at ~46 times higher odds to develop premature MI compared with individuals without the E4 allele [adjusted odds ratio, OR (95% confidence interval, CI): 45.7 (4.9-421.3)]. Among conventional risk factors, higher risk was observed in those having dyslipidaemia [OR (95% CI): 8.7 (0.9-86.6)] and those with a high waist : hip ratio [OR (95% CI): 5.6 (1.4-21.2)]. CONCLUSION: Based on the robust association, the apo E4 allele should be considered as an independent risk factor for premature MI in Asian Indians. SN - 0004-5632 UR - https://www.unboundmedicine.com/medline/citation/12880539/Apolipoprotein_E_gene_polymorphisms_in_patients_with_premature_myocardial_infarction:_a_case_controlled_study_in_Asian_Indians_in_North_India_ L2 - https://journals.sagepub.com/doi/10.1258/000456303766477020?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -