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In vivo evaluation of guar gum-based colon-targeted drug delivery systems of ornidazole in healthy human volunteers.
J Drug Target. 2003 Feb; 11(2):109-15.JD

Abstract

The aim of the present study was to find the in vivo performance of guar gum-based colon-targeted tablets of ornidazole (dose 250 mg) in comparison with an immediate release tablet of ornidazole (250 mg) in human volunteers. Six healthy volunteers participated in the study, and a cross over design was followed. The plasma concentration of ornidazole was estimated by HPLC. The immediate release tablets of ornidazole produced peak plasma concentration (Cmax of 2171.33+/-278.15 ng/ml) at 2.91+/-0.14 h (Tmax) whereas colon-targeted tablets produced peak plasma concentration (Cmax of 1716.66+/-125.83 ng/ml) at 11.91+/-0.14 h. The delayed Tmax, decreased Cmax, and decreased ka of ornidazole from guar gum-based colon-targeted ornidazole tablets, in comparison with the immediate tablets, indicated that the drug was not released in stomach and small intestine, but targeted to colon. Slow absorption of ornidazole from the less absorptive colon might result in the availability of drug for local action in the colon.

Authors+Show Affiliations

Krishnaiah YS
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India. krishnaysr112@rediffmail.com
Indira Muzib Y
No affiliation info available
Bhaskar P
No affiliation info available

MeSH

AdultAnimalsAntiprotozoal AgentsArea Under CurveBiological AvailabilityChromatography, High Pressure LiquidCross-Over StudiesDelayed-Action PreparationsDrug CarriersGalactansGastrointestinal ContentsHalf-LifeHumansIn Vitro TechniquesIntestinal AbsorptionMannansOrnidazolePlant GumsRatsSolubility

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12881197

Citation

Krishnaiah, Y S R., et al. "In Vivo Evaluation of Guar Gum-based Colon-targeted Drug Delivery Systems of Ornidazole in Healthy Human Volunteers." Journal of Drug Targeting, vol. 11, no. 2, 2003, pp. 109-15.
Krishnaiah YS, Indira Muzib Y, Bhaskar P. In vivo evaluation of guar gum-based colon-targeted drug delivery systems of ornidazole in healthy human volunteers. J Drug Target. 2003;11(2):109-15.
Krishnaiah, Y. S., Indira Muzib, Y., & Bhaskar, P. (2003). In vivo evaluation of guar gum-based colon-targeted drug delivery systems of ornidazole in healthy human volunteers. Journal of Drug Targeting, 11(2), 109-15.
Krishnaiah YS, Indira Muzib Y, Bhaskar P. In Vivo Evaluation of Guar Gum-based Colon-targeted Drug Delivery Systems of Ornidazole in Healthy Human Volunteers. J Drug Target. 2003;11(2):109-15. PubMed PMID: 12881197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo evaluation of guar gum-based colon-targeted drug delivery systems of ornidazole in healthy human volunteers. AU - Krishnaiah,Y S R, AU - Indira Muzib,Y, AU - Bhaskar,P, PY - 2003/7/26/pubmed PY - 2003/10/22/medline PY - 2003/7/26/entrez SP - 109 EP - 15 JF - Journal of drug targeting JO - J Drug Target VL - 11 IS - 2 N2 - The aim of the present study was to find the in vivo performance of guar gum-based colon-targeted tablets of ornidazole (dose 250 mg) in comparison with an immediate release tablet of ornidazole (250 mg) in human volunteers. Six healthy volunteers participated in the study, and a cross over design was followed. The plasma concentration of ornidazole was estimated by HPLC. The immediate release tablets of ornidazole produced peak plasma concentration (Cmax of 2171.33+/-278.15 ng/ml) at 2.91+/-0.14 h (Tmax) whereas colon-targeted tablets produced peak plasma concentration (Cmax of 1716.66+/-125.83 ng/ml) at 11.91+/-0.14 h. The delayed Tmax, decreased Cmax, and decreased ka of ornidazole from guar gum-based colon-targeted ornidazole tablets, in comparison with the immediate tablets, indicated that the drug was not released in stomach and small intestine, but targeted to colon. Slow absorption of ornidazole from the less absorptive colon might result in the availability of drug for local action in the colon. SN - 1061-186X UR - https://www.unboundmedicine.com/medline/citation/12881197/In_vivo_evaluation_of_guar_gum_based_colon_targeted_drug_delivery_systems_of_ornidazole_in_healthy_human_volunteers_ DB - PRIME DP - Unbound Medicine ER -