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Ciguatera fish poisoning in the Caribbean islands and Western Atlantic.
Rev Environ Contam Toxicol. 2001; 168:99-141.RE

Abstract

Ciguatera fish poisoning (ciguatera), a common poisoning caused by fish ingestion, is reviewed in the Western Atlantic and the Caribbean waters. It is endemic from Florida coasts (northern limit) to Martinique Island (southern limit), with outbreaks occurring from time to time. In the Caribbean, ciguatera causes a polymorphic syndrome with gastrointestinal, cardiovascular, and neurological signs and symptoms. Neurological and muscular dysfunctions can be treated by intravenous injection of D-mannitol. The lipid-soluble toxins involved are ciguatoxins that are likely produced by the dinoflagellate Gambierdiscus toxicus. G. toxicus strains are endemic in the Caribbean Sea and in theWestern Atlantic. Although it is likely that blooms of G. toxicus are ingested by herbivorous fishes, they are not implicated in ciguatera in the Caribbean. Rather, large carnivores (barracudas, jacks, snappers, groupers), consumers of smaller benthic fish, are often involved in ciguatera. Fish toxicity depends on fishing area and depth, fish size and tissues, and climatic disturbances. Ciguatoxins have been isolated and purified from Caribbean fish species. The structure of two epimers, C-CTX-1 and C-CTX-2 from horse-eye jack, comprise 14 trans-fused ether-linked rings and a hemiketal in terminal ring. Caribbean ciguatoxins are mainly detected in the laboratory by chicken, mouse, mosquito, or cell bioassays, and by analytical HPLC/tandem mass spectrometry down to parts per billion (ppb). A ciguatera management plan that integrates epidemiology, treatment, and a simple method of detection is required to ensure the protection of consumers.

Authors+Show Affiliations

Laboratoire de Microbiologie Alimentaire, Universite de Caen, Esplanade de la Paix, 14032 Caen Cedex, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12882228

Citation

Pottier, I, et al. "Ciguatera Fish Poisoning in the Caribbean Islands and Western Atlantic." Reviews of Environmental Contamination and Toxicology, vol. 168, 2001, pp. 99-141.
Pottier I, Vernoux JP, Lewis RJ. Ciguatera fish poisoning in the Caribbean islands and Western Atlantic. Rev Environ Contam Toxicol. 2001;168:99-141.
Pottier, I., Vernoux, J. P., & Lewis, R. J. (2001). Ciguatera fish poisoning in the Caribbean islands and Western Atlantic. Reviews of Environmental Contamination and Toxicology, 168, 99-141.
Pottier I, Vernoux JP, Lewis RJ. Ciguatera Fish Poisoning in the Caribbean Islands and Western Atlantic. Rev Environ Contam Toxicol. 2001;168:99-141. PubMed PMID: 12882228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ciguatera fish poisoning in the Caribbean islands and Western Atlantic. AU - Pottier,I, AU - Vernoux,J P, AU - Lewis,R J, PY - 2003/7/29/pubmed PY - 2003/8/14/medline PY - 2003/7/29/entrez SP - 99 EP - 141 JF - Reviews of environmental contamination and toxicology JO - Rev Environ Contam Toxicol VL - 168 N2 - Ciguatera fish poisoning (ciguatera), a common poisoning caused by fish ingestion, is reviewed in the Western Atlantic and the Caribbean waters. It is endemic from Florida coasts (northern limit) to Martinique Island (southern limit), with outbreaks occurring from time to time. In the Caribbean, ciguatera causes a polymorphic syndrome with gastrointestinal, cardiovascular, and neurological signs and symptoms. Neurological and muscular dysfunctions can be treated by intravenous injection of D-mannitol. The lipid-soluble toxins involved are ciguatoxins that are likely produced by the dinoflagellate Gambierdiscus toxicus. G. toxicus strains are endemic in the Caribbean Sea and in theWestern Atlantic. Although it is likely that blooms of G. toxicus are ingested by herbivorous fishes, they are not implicated in ciguatera in the Caribbean. Rather, large carnivores (barracudas, jacks, snappers, groupers), consumers of smaller benthic fish, are often involved in ciguatera. Fish toxicity depends on fishing area and depth, fish size and tissues, and climatic disturbances. Ciguatoxins have been isolated and purified from Caribbean fish species. The structure of two epimers, C-CTX-1 and C-CTX-2 from horse-eye jack, comprise 14 trans-fused ether-linked rings and a hemiketal in terminal ring. Caribbean ciguatoxins are mainly detected in the laboratory by chicken, mouse, mosquito, or cell bioassays, and by analytical HPLC/tandem mass spectrometry down to parts per billion (ppb). A ciguatera management plan that integrates epidemiology, treatment, and a simple method of detection is required to ensure the protection of consumers. SN - 0179-5953 UR - https://www.unboundmedicine.com/medline/citation/12882228/Ciguatera_fish_poisoning_in_the_Caribbean_islands_and_Western_Atlantic_ L2 - http://www.diseaseinfosearch.org/result/1638 DB - PRIME DP - Unbound Medicine ER -