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A case-control study of the risk of breast cancer in relation to oral contraceptive use.
Am J Epidemiol. 1992 Dec 15; 136(12):1437-44.AJ

Abstract

The relation of oral contraceptive use to the risk of breast cancer was evaluated in a case-control study of women under the age of 70 years, conducted in Toronto, Canada, from 1982 through 1986. A total of 607 breast cancer cases identified in a cancer hospital were compared with 1,214 controls matched to the cases on neighborhood and decade of age. Information on oral contraceptive use and risk factors for breast cancer was collected in home interviews. Conditional logistic regression was used to control multiple confounding factors. For women aged 40-69 years (527 cases, 1,054 controls), the results suggest that oral contraceptive use does not increase the risk of breast cancer. Multivariate relative risk estimates were close to or below 1.0 for long durations of use overall and in various categories of parity status and other factors. For women under the age of 40 years, the data were sparse (80 cases, 160 controls). Although there were some elevated relative risk estimates, most were not statistically significant, and there were no consistent patterns across duration of use. The present data add to the body of evidence that indicates that oral contraceptive use does not adversely affect the risk of breast cancer in older women; the data are inadequate to clarify the effect in younger women.

Authors+Show Affiliations

Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, MA 02146.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1288273

Citation

Rosenberg, L, et al. "A Case-control Study of the Risk of Breast Cancer in Relation to Oral Contraceptive Use." American Journal of Epidemiology, vol. 136, no. 12, 1992, pp. 1437-44.
Rosenberg L, Palmer JR, Clarke EA, et al. A case-control study of the risk of breast cancer in relation to oral contraceptive use. Am J Epidemiol. 1992;136(12):1437-44.
Rosenberg, L., Palmer, J. R., Clarke, E. A., & Shapiro, S. (1992). A case-control study of the risk of breast cancer in relation to oral contraceptive use. American Journal of Epidemiology, 136(12), 1437-44.
Rosenberg L, et al. A Case-control Study of the Risk of Breast Cancer in Relation to Oral Contraceptive Use. Am J Epidemiol. 1992 Dec 15;136(12):1437-44. PubMed PMID: 1288273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study of the risk of breast cancer in relation to oral contraceptive use. AU - Rosenberg,L, AU - Palmer,J R, AU - Clarke,E A, AU - Shapiro,S, PY - 1992/12/15/pubmed PY - 1992/12/15/medline PY - 1992/12/15/entrez KW - Age Factors KW - Americas KW - Biology KW - Breast Cancer KW - Canada KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Contraceptive Usage--women KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Family Planning KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives KW - Population KW - Population Characteristics KW - Research Methodology KW - Risk Factors KW - Studies SP - 1437 EP - 44 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 136 IS - 12 N2 - The relation of oral contraceptive use to the risk of breast cancer was evaluated in a case-control study of women under the age of 70 years, conducted in Toronto, Canada, from 1982 through 1986. A total of 607 breast cancer cases identified in a cancer hospital were compared with 1,214 controls matched to the cases on neighborhood and decade of age. Information on oral contraceptive use and risk factors for breast cancer was collected in home interviews. Conditional logistic regression was used to control multiple confounding factors. For women aged 40-69 years (527 cases, 1,054 controls), the results suggest that oral contraceptive use does not increase the risk of breast cancer. Multivariate relative risk estimates were close to or below 1.0 for long durations of use overall and in various categories of parity status and other factors. For women under the age of 40 years, the data were sparse (80 cases, 160 controls). Although there were some elevated relative risk estimates, most were not statistically significant, and there were no consistent patterns across duration of use. The present data add to the body of evidence that indicates that oral contraceptive use does not adversely affect the risk of breast cancer in older women; the data are inadequate to clarify the effect in younger women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/1288273/A_case_control_study_of_the_risk_of_breast_cancer_in_relation_to_oral_contraceptive_use_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a116464 DB - PRIME DP - Unbound Medicine ER -