Tags

Type your tag names separated by a space and hit enter

Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.
Clin Infect Dis. 2003 Aug 01; 37(3):450-1.CI

Abstract

We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

Authors+Show Affiliations

Center for Geographic Medicine and Department of Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12884171

Citation

Schwartz, Eli, et al. "Genetic Confirmation of Atovaquone-proguanil-resistant Plasmodium Falciparum Malaria Acquired By a Nonimmune Traveler to East Africa." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 37, no. 3, 2003, pp. 450-1.
Schwartz E, Bujanover S, Kain KC. Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa. Clin Infect Dis. 2003;37(3):450-1.
Schwartz, E., Bujanover, S., & Kain, K. C. (2003). Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 37(3), 450-1.
Schwartz E, Bujanover S, Kain KC. Genetic Confirmation of Atovaquone-proguanil-resistant Plasmodium Falciparum Malaria Acquired By a Nonimmune Traveler to East Africa. Clin Infect Dis. 2003 Aug 1;37(3):450-1. PubMed PMID: 12884171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa. AU - Schwartz,Eli, AU - Bujanover,Shay, AU - Kain,Kevin C, Y1 - 2003/07/18/ PY - 2003/01/07/received PY - 2003/03/05/accepted PY - 2003/7/29/pubmed PY - 2003/8/29/medline PY - 2003/7/29/entrez SP - 450 EP - 1 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 37 IS - 3 N2 - We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser). SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/12884171/Genetic_confirmation_of_atovaquone_proguanil_resistant_Plasmodium_falciparum_malaria_acquired_by_a_nonimmune_traveler_to_East_Africa_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/375599 DB - PRIME DP - Unbound Medicine ER -