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Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory.
Learn Mem. 2003 Jul-Aug; 10(4):293-303.LM

Abstract

Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV), into the basolateral amygdala (BLA) were found to be impaired in two-way active avoidance learning. During multitrial training in a shuttle box, the APV-injected rats were not different from the controls in sensitivity to shock or in acquisition of freezing to contextual cues. However, APV injection led to impaired retention of contextual fear when tested 48 h later, along with an attenuation of c-Fos expression in the amygdala. These results are consistent with the role of NMDA receptors of the BLA in long-term memory of fear, previously documented in Pavlovian conditioning paradigms. The APV-induced impairment in the active avoidance learning coincided with deficits in directionality of the escape reaction and in attention to conditioned stimuli. These data indicate that normal functioning of NMDA receptors in the basolateral amygdala is required during acquisition of adaptive instrumental responses in a shuttle box but is not necessary for acquisition of short-term contextual fear in this situation.

Authors+Show Affiliations

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA. asavone1@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12888548

Citation

Savonenko, Alena, et al. "Complex Effects of NMDA Receptor Antagonist APV in the Basolateral Amygdala On Acquisition of Two-way Avoidance Reaction and Long-term Fear Memory." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 10, no. 4, 2003, pp. 293-303.
Savonenko A, Werka T, Nikolaev E, et al. Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory. Learn Mem. 2003;10(4):293-303.
Savonenko, A., Werka, T., Nikolaev, E., Zieliñski, K., & Kaczmarek, L. (2003). Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory. Learning & Memory (Cold Spring Harbor, N.Y.), 10(4), 293-303.
Savonenko A, et al. Complex Effects of NMDA Receptor Antagonist APV in the Basolateral Amygdala On Acquisition of Two-way Avoidance Reaction and Long-term Fear Memory. Learn Mem. 2003 Jul-Aug;10(4):293-303. PubMed PMID: 12888548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complex effects of NMDA receptor antagonist APV in the basolateral amygdala on acquisition of two-way avoidance reaction and long-term fear memory. AU - Savonenko,Alena, AU - Werka,Tomasz, AU - Nikolaev,Evgeni, AU - Zieliñski,Kazimierz, AU - Kaczmarek,Leszek, PY - 2003/7/31/pubmed PY - 2003/10/24/medline PY - 2003/7/31/entrez SP - 293 EP - 303 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 10 IS - 4 N2 - Although much has been learned about the role of the amygdala in Pavlovian fear conditioning, relatively little is known about an involvement of this structure in more complex aversive learning, such as acquisition of an active avoidance reaction. In the present study, rats with a pretraining injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV), into the basolateral amygdala (BLA) were found to be impaired in two-way active avoidance learning. During multitrial training in a shuttle box, the APV-injected rats were not different from the controls in sensitivity to shock or in acquisition of freezing to contextual cues. However, APV injection led to impaired retention of contextual fear when tested 48 h later, along with an attenuation of c-Fos expression in the amygdala. These results are consistent with the role of NMDA receptors of the BLA in long-term memory of fear, previously documented in Pavlovian conditioning paradigms. The APV-induced impairment in the active avoidance learning coincided with deficits in directionality of the escape reaction and in attention to conditioned stimuli. These data indicate that normal functioning of NMDA receptors in the basolateral amygdala is required during acquisition of adaptive instrumental responses in a shuttle box but is not necessary for acquisition of short-term contextual fear in this situation. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/12888548/Complex_effects_of_NMDA_receptor_antagonist_APV_in_the_basolateral_amygdala_on_acquisition_of_two_way_avoidance_reaction_and_long_term_fear_memory_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/12888548/ DB - PRIME DP - Unbound Medicine ER -