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Plasma antioxidants and type 2 diabetes mellitus.
Res Commun Mol Pathol Pharmacol. 2001; 109(5-6):309-18.RC

Abstract

Reports indicate that some complications of diabetes mellitus are associated with increased activity of free radicals and accumulation of lipid peroxidation products. The organism's susceptibility to free radical stress and peroxidative damage is related to the balance between the free radical load and the adequacy of antioxidant defenses. In the present study, the relationship between plasma oxidants and antioxidants in diabetes mellitus was investigated. Thirty patients with type-2 diabetes mellitus were examined as well as twenty healthy controls (matched for age and sex against the diabetic patients). The plasma insulin and C-peptide levels in the diabetic group were significantly lower (p < 0.001) than that of the control group. The mean plasma fructosamine, lipid peroxide, lipids and low-density lipoprotein cholesterol (LDL-C) levels were significantly high (p < 0.001) in the diabetic group compared to the control group. There were not any significant differences in the plasma high-density lipoprotein cholesterol (HDL-C) levels between the patients and the control group (p < 0.001). The type-2 diabetes mellitus patients exhibited higher activities of plasma superoxide dismutase (SOD) than control values, whereas plasma glutathione peroxidase (GPx) activities were significantly lower. Our results suggest that there seems to be an imbalance between plasma oxidant and antioxidant systems in patients with type-2 diabetes mellitus. The estimation of plasma antioxidant levels and their replenishment by exogenous agents when necessary may be useful in the prevention of the diabetic complications.

Authors+Show Affiliations

Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12889514

Citation

Palanduz, S, et al. "Plasma Antioxidants and Type 2 Diabetes Mellitus." Research Communications in Molecular Pathology and Pharmacology, vol. 109, no. 5-6, 2001, pp. 309-18.
Palanduz S, Ademoğlu E, Gökkuşu C, et al. Plasma antioxidants and type 2 diabetes mellitus. Res Commun Mol Pathol Pharmacol. 2001;109(5-6):309-18.
Palanduz, S., Ademoğlu, E., Gökkuşu, C., & Tamer, S. (2001). Plasma antioxidants and type 2 diabetes mellitus. Research Communications in Molecular Pathology and Pharmacology, 109(5-6), 309-18.
Palanduz S, et al. Plasma Antioxidants and Type 2 Diabetes Mellitus. Res Commun Mol Pathol Pharmacol. 2001;109(5-6):309-18. PubMed PMID: 12889514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma antioxidants and type 2 diabetes mellitus. AU - Palanduz,S, AU - Ademoğlu,E, AU - Gökkuşu,C, AU - Tamer,S, PY - 2003/8/2/pubmed PY - 2003/8/13/medline PY - 2003/8/2/entrez SP - 309 EP - 18 JF - Research communications in molecular pathology and pharmacology JO - Res Commun Mol Pathol Pharmacol VL - 109 IS - 5-6 N2 - Reports indicate that some complications of diabetes mellitus are associated with increased activity of free radicals and accumulation of lipid peroxidation products. The organism's susceptibility to free radical stress and peroxidative damage is related to the balance between the free radical load and the adequacy of antioxidant defenses. In the present study, the relationship between plasma oxidants and antioxidants in diabetes mellitus was investigated. Thirty patients with type-2 diabetes mellitus were examined as well as twenty healthy controls (matched for age and sex against the diabetic patients). The plasma insulin and C-peptide levels in the diabetic group were significantly lower (p < 0.001) than that of the control group. The mean plasma fructosamine, lipid peroxide, lipids and low-density lipoprotein cholesterol (LDL-C) levels were significantly high (p < 0.001) in the diabetic group compared to the control group. There were not any significant differences in the plasma high-density lipoprotein cholesterol (HDL-C) levels between the patients and the control group (p < 0.001). The type-2 diabetes mellitus patients exhibited higher activities of plasma superoxide dismutase (SOD) than control values, whereas plasma glutathione peroxidase (GPx) activities were significantly lower. Our results suggest that there seems to be an imbalance between plasma oxidant and antioxidant systems in patients with type-2 diabetes mellitus. The estimation of plasma antioxidant levels and their replenishment by exogenous agents when necessary may be useful in the prevention of the diabetic complications. SN - 1078-0297 UR - https://www.unboundmedicine.com/medline/citation/12889514/Plasma_antioxidants_and_type_2_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -