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Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study).
J Am Geriatr Soc 2003; 51(8):1064-71JA

Abstract

OBJECTIVES

To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition.

DESIGN

First wave of an epidemiological longitudinal study (InCHIANTI) on factors predicting loss of mobility in older persons.

SETTING

The Chianti geographic area (Tuscany, Italy).

PARTICIPANTS

Five hundred fifty-six subjects aged 70 to 90 with Mini-Mental State Examination (MMSE) scores greater than 23 of 30, of the 1,260 persons aged 65 and older randomly selected from the population registry of Greve in Chianti and Bagno a Ripoli, two small towns near Florence.

METHODS

Low cognitive performance (LCP) was defined as an age- and education-adjusted MMSE below the 50th percentile for the InCHIANTI population. Subcortical features were plastic rigidity on neurological examination (parkinsonism), gait disturbance (small-step gait or parkinsonian gait), and dysexecutive features. Two hundred forty-three participants had high cognitive performance, 166 had LCP without subcortical features, and 75 had LCP with subcortical features. Vascular risk factors were hypertension, atrial fibrillation or pathological findings on electrocardiogram (ECG), low serum high-density lipoprotein (HDL) or high low-density lipoprotein cholesterol, diabetes mellitus, obesity, and heavy smoking.

RESULTS

Three main vascular risk factors were significantly more prevalent in LCP with subcortical features: hypertension (P =.02), atrial fibrillation or ECG changes (P =.04), and low HDL cholesterol (P =.001). LCP with subcortical features was significantly associated with cerebrovascular risk factors (P =.001).

CONCLUSION

Gait disturbance and nonamnestic cognitive symptoms might be the consequence of subcortical vascular damage.

Authors+Show Affiliations

Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, Brescia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12890067

Citation

Geroldi, Cristina, et al. "Mild Cognitive Deterioration With Subcortical Features: Prevalence, Clinical Characteristics, and Association With Cardiovascular Risk Factors in Community-dwelling Older Persons (The InCHIANTI Study)." Journal of the American Geriatrics Society, vol. 51, no. 8, 2003, pp. 1064-71.
Geroldi C, Ferrucci L, Bandinelli S, et al. Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study). J Am Geriatr Soc. 2003;51(8):1064-71.
Geroldi, C., Ferrucci, L., Bandinelli, S., Cavazzini, C., Zanetti, O., Guralnik, J. M., & Frisoni, G. B. (2003). Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study). Journal of the American Geriatrics Society, 51(8), pp. 1064-71.
Geroldi C, et al. Mild Cognitive Deterioration With Subcortical Features: Prevalence, Clinical Characteristics, and Association With Cardiovascular Risk Factors in Community-dwelling Older Persons (The InCHIANTI Study). J Am Geriatr Soc. 2003;51(8):1064-71. PubMed PMID: 12890067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study). AU - Geroldi,Cristina, AU - Ferrucci,Luigi, AU - Bandinelli,Stefania, AU - Cavazzini,Chiara, AU - Zanetti,Orazio, AU - Guralnik,Jack M, AU - Frisoni,Giovanni B, AU - ,, PY - 2003/8/2/pubmed PY - 2003/10/3/medline PY - 2003/8/2/entrez SP - 1064 EP - 71 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 51 IS - 8 N2 - OBJECTIVES: To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition. DESIGN: First wave of an epidemiological longitudinal study (InCHIANTI) on factors predicting loss of mobility in older persons. SETTING: The Chianti geographic area (Tuscany, Italy). PARTICIPANTS: Five hundred fifty-six subjects aged 70 to 90 with Mini-Mental State Examination (MMSE) scores greater than 23 of 30, of the 1,260 persons aged 65 and older randomly selected from the population registry of Greve in Chianti and Bagno a Ripoli, two small towns near Florence. METHODS: Low cognitive performance (LCP) was defined as an age- and education-adjusted MMSE below the 50th percentile for the InCHIANTI population. Subcortical features were plastic rigidity on neurological examination (parkinsonism), gait disturbance (small-step gait or parkinsonian gait), and dysexecutive features. Two hundred forty-three participants had high cognitive performance, 166 had LCP without subcortical features, and 75 had LCP with subcortical features. Vascular risk factors were hypertension, atrial fibrillation or pathological findings on electrocardiogram (ECG), low serum high-density lipoprotein (HDL) or high low-density lipoprotein cholesterol, diabetes mellitus, obesity, and heavy smoking. RESULTS: Three main vascular risk factors were significantly more prevalent in LCP with subcortical features: hypertension (P =.02), atrial fibrillation or ECG changes (P =.04), and low HDL cholesterol (P =.001). LCP with subcortical features was significantly associated with cerebrovascular risk factors (P =.001). CONCLUSION: Gait disturbance and nonamnestic cognitive symptoms might be the consequence of subcortical vascular damage. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/12890067/Mild_cognitive_deterioration_with_subcortical_features:_prevalence_clinical_characteristics_and_association_with_cardiovascular_risk_factors_in_community_dwelling_older_persons__The_InCHIANTI_Study__ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=2003&volume=51&issue=8&spage=1064 DB - PRIME DP - Unbound Medicine ER -