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308-nm excimer laser for the treatment of localized vitiligo.
Int J Dermatol. 2003 Aug; 42(8):658-62.IJ

Abstract

BACKGROUND AND OBJECTIVE

Vitiligo is commonly treated with PUVA, and more recently, narrow-band UVB (NBUVB) phototherapy. Given the proximity of the wavelengths of NBUVB (311 nm) and the excimer laser (308 nm), we undertook a clinical trial to test the efficacy of this device.

METHODS

Twice-weekly 308-nm UV-B radiation was given to selected vitiligo lesions for a maximum of 60 treatments. These lesions had been unsuccessfully treated previously with at least one other method of treatment. Initial doses were 100 mJ/cm2 with increments of 10-25%. Improvement was assessed on a visual scale via serial photographs.

RESULTS

Subjects tolerated the treatment well. Improvement varied with body site. After 60 treatments, lesions on the hands and feet showed grade 2 improvement in 2/10 subjects and grade 1 in 8/10. For the axillae, there was grade 4 improvement in 1/3 subjects and grade 2 improvement in 2/3 by treatment 60. The face demonstrated the most rapid repigmentation with grade 4 repigmentation seen in 3/5 subjects by 40 treatments and grade 3 in 2/5 by 30 treatments. There were no adverse effects.

CONCLUSIONS

The user-friendly 308-nm excimer laser allows targeted treatments of localized vitiligo.

Authors+Show Affiliations

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12890118

Citation

Taneja, Atul, et al. "308-nm Excimer Laser for the Treatment of Localized Vitiligo." International Journal of Dermatology, vol. 42, no. 8, 2003, pp. 658-62.
Taneja A, Trehan M, Taylor CR. 308-nm excimer laser for the treatment of localized vitiligo. Int J Dermatol. 2003;42(8):658-62.
Taneja, A., Trehan, M., & Taylor, C. R. (2003). 308-nm excimer laser for the treatment of localized vitiligo. International Journal of Dermatology, 42(8), 658-62.
Taneja A, Trehan M, Taylor CR. 308-nm Excimer Laser for the Treatment of Localized Vitiligo. Int J Dermatol. 2003;42(8):658-62. PubMed PMID: 12890118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 308-nm excimer laser for the treatment of localized vitiligo. AU - Taneja,Atul, AU - Trehan,Manju, AU - Taylor,Charles R, PY - 2003/8/2/pubmed PY - 2004/2/5/medline PY - 2003/8/2/entrez SP - 658 EP - 62 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 42 IS - 8 N2 - BACKGROUND AND OBJECTIVE: Vitiligo is commonly treated with PUVA, and more recently, narrow-band UVB (NBUVB) phototherapy. Given the proximity of the wavelengths of NBUVB (311 nm) and the excimer laser (308 nm), we undertook a clinical trial to test the efficacy of this device. METHODS: Twice-weekly 308-nm UV-B radiation was given to selected vitiligo lesions for a maximum of 60 treatments. These lesions had been unsuccessfully treated previously with at least one other method of treatment. Initial doses were 100 mJ/cm2 with increments of 10-25%. Improvement was assessed on a visual scale via serial photographs. RESULTS: Subjects tolerated the treatment well. Improvement varied with body site. After 60 treatments, lesions on the hands and feet showed grade 2 improvement in 2/10 subjects and grade 1 in 8/10. For the axillae, there was grade 4 improvement in 1/3 subjects and grade 2 improvement in 2/3 by treatment 60. The face demonstrated the most rapid repigmentation with grade 4 repigmentation seen in 3/5 subjects by 40 treatments and grade 3 in 2/5 by 30 treatments. There were no adverse effects. CONCLUSIONS: The user-friendly 308-nm excimer laser allows targeted treatments of localized vitiligo. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/12890118/308_nm_excimer_laser_for_the_treatment_of_localized_vitiligo_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=2003&volume=42&issue=8&spage=658 DB - PRIME DP - Unbound Medicine ER -