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Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts.
Acta Psychiatr Scand. 2003 Sep; 108(3):208-14.AP

Abstract

OBJECTIVE

Previous studies demonstrate a relationship between lipid metabolism and suicide or impulsive-aggressive behaviours. Leptin seems to be related with lipid metabolism. Therefore, the aim was to measure total serum cholesterol and leptin levels in 16 medication-free schizophrenic patients with and without suicide attempts and in 16 healthy controls.

METHOD

Subjects were assessed by using Impulsivity Rating (IRS) and Modified Overt Aggression Scale (MOAS).

RESULTS

The patients had lower total cholesterol and leptin levels in serum compared with the controls. Significantly lower total cholesterol and leptin levels were observed in patients who had attempted suicide compared with those who had not. The levels were observed to be low in violent attempters when compared with non-violent attempters. MOAS and IRS scores were negatively correlated with both cholesterol or leptin levels in patients.

CONCLUSION

The results indicated that medication-free schizophrenic patients have statistically significant lower serum cholesterol and leptin levels compared with controls and the difference is obvious in suicide attempters compared with non-suicide attempters and in violent attempters than non-violent attempters.

Authors+Show Affiliations

Atmaca M
Departments of Psychiatry and Clinical Biochemistry, Firat University, School of Medicine, Elazig, Turkey. matmaca_p@yahoo.com
Kuloglu M
No affiliation info available
Tezcan E
No affiliation info available
Ustundag B
No affiliation info available

MeSH

AdultAggressionAnalysis of VarianceCholesterolCross-Sectional StudiesFemaleHumansImpulsive BehaviorLeptinMaleMiddle AgedPredictive Value of TestsPsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologySuicide, AttemptedViolence

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12890276

Citation

Atmaca, M, et al. "Serum Leptin and Cholesterol Levels in Schizophrenic Patients With and Without Suicide Attempts." Acta Psychiatrica Scandinavica, vol. 108, no. 3, 2003, pp. 208-14.
Atmaca M, Kuloglu M, Tezcan E, et al. Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr Scand. 2003;108(3):208-14.
Atmaca, M., Kuloglu, M., Tezcan, E., & Ustundag, B. (2003). Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatrica Scandinavica, 108(3), 208-14.
Atmaca M, et al. Serum Leptin and Cholesterol Levels in Schizophrenic Patients With and Without Suicide Attempts. Acta Psychiatr Scand. 2003;108(3):208-14. PubMed PMID: 12890276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. AU - Atmaca,M, AU - Kuloglu,M, AU - Tezcan,E, AU - Ustundag,B, PY - 2003/8/2/pubmed PY - 2004/2/10/medline PY - 2003/8/2/entrez SP - 208 EP - 14 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 108 IS - 3 N2 - OBJECTIVE: Previous studies demonstrate a relationship between lipid metabolism and suicide or impulsive-aggressive behaviours. Leptin seems to be related with lipid metabolism. Therefore, the aim was to measure total serum cholesterol and leptin levels in 16 medication-free schizophrenic patients with and without suicide attempts and in 16 healthy controls. METHOD: Subjects were assessed by using Impulsivity Rating (IRS) and Modified Overt Aggression Scale (MOAS). RESULTS: The patients had lower total cholesterol and leptin levels in serum compared with the controls. Significantly lower total cholesterol and leptin levels were observed in patients who had attempted suicide compared with those who had not. The levels were observed to be low in violent attempters when compared with non-violent attempters. MOAS and IRS scores were negatively correlated with both cholesterol or leptin levels in patients. CONCLUSION: The results indicated that medication-free schizophrenic patients have statistically significant lower serum cholesterol and leptin levels compared with controls and the difference is obvious in suicide attempters compared with non-suicide attempters and in violent attempters than non-violent attempters. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/12890276/Serum_leptin_and_cholesterol_levels_in_schizophrenic_patients_with_and_without_suicide_attempts_ DB - PRIME DP - Unbound Medicine ER -