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Pathological study on severe acute respiratory syndrome.
Chin Med J (Engl). 2003 Jul; 116(7):976-80.CM

Abstract

OBJECTIVE

To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation.

METHODS

Tissue specimens from 3 autopsies of probable SARS cases were studied by microscope, and the clinical data was reviewed.

RESULTS

The typical pathological changes of lungs were diffuse hemorrhaging on the surface. A combination of serous, fibrinous and hemorrhagic inflammation was seen in most of the pulmonary alveoli with the engorgement of capillaries and detection of micro-thrombosis in some of these capillaries. Pulmonary alveoli thickened with interstitial mononuclear inflammatory infiltrates, suffered diffuse alveolar damage, experienced desquamation of pneumocytes and had hyaline-membrane formation, fibrinoid materials, and erythrocytes in alveolar spaces. There were thromboembolisms in some bronchial arteries. Furthermore, hemorrhagic necrosis was also evident in lymph nodes and spleen with the attenuation of lymphocytes. Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and lesions having existed before hospitalization were observed in the liver, heart, kidney and pancreas.

CONCLUSION

Severe damage to the pulmonary and immunological systems is responsible for the clinical features of SARS and may lead to the death of patients.

Authors+Show Affiliations

Department of Pathology, Beijing Youan Hospital, Capital University of Medical Sciences, Beijing 100054, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12890365

Citation

Lang, Zhenwei, et al. "Pathological Study On Severe Acute Respiratory Syndrome." Chinese Medical Journal, vol. 116, no. 7, 2003, pp. 976-80.
Lang Z, Zhang L, Zhang S, et al. Pathological study on severe acute respiratory syndrome. Chin Med J (Engl). 2003;116(7):976-80.
Lang, Z., Zhang, L., Zhang, S., Meng, X., Li, J., Song, C., Sun, L., & Zhou, Y. (2003). Pathological study on severe acute respiratory syndrome. Chinese Medical Journal, 116(7), 976-80.
Lang Z, et al. Pathological Study On Severe Acute Respiratory Syndrome. Chin Med J (Engl). 2003;116(7):976-80. PubMed PMID: 12890365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathological study on severe acute respiratory syndrome. AU - Lang,Zhenwei, AU - Zhang,Lijie, AU - Zhang,Shijie, AU - Meng,Xin, AU - Li,Junqiang, AU - Song,Chenzhao, AU - Sun,Lin, AU - Zhou,Yusen, PY - 2003/8/2/pubmed PY - 2003/10/18/medline PY - 2003/8/2/entrez SP - 976 EP - 80 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 116 IS - 7 N2 - OBJECTIVE: To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation. METHODS: Tissue specimens from 3 autopsies of probable SARS cases were studied by microscope, and the clinical data was reviewed. RESULTS: The typical pathological changes of lungs were diffuse hemorrhaging on the surface. A combination of serous, fibrinous and hemorrhagic inflammation was seen in most of the pulmonary alveoli with the engorgement of capillaries and detection of micro-thrombosis in some of these capillaries. Pulmonary alveoli thickened with interstitial mononuclear inflammatory infiltrates, suffered diffuse alveolar damage, experienced desquamation of pneumocytes and had hyaline-membrane formation, fibrinoid materials, and erythrocytes in alveolar spaces. There were thromboembolisms in some bronchial arteries. Furthermore, hemorrhagic necrosis was also evident in lymph nodes and spleen with the attenuation of lymphocytes. Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and lesions having existed before hospitalization were observed in the liver, heart, kidney and pancreas. CONCLUSION: Severe damage to the pulmonary and immunological systems is responsible for the clinical features of SARS and may lead to the death of patients. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/12890365/Pathological_study_on_severe_acute_respiratory_syndrome_ DB - PRIME DP - Unbound Medicine ER -