Tags

Type your tag names separated by a space and hit enter

[Single-dose ceftriaxone versus multiple-dose cefuroxime for prophylaxis of surgical site infection].
Zhonghua Wai Ke Za Zhi. 2003 May; 41(5):372-4.ZW

Abstract

OBJECTIVE

To compare the effects and pharmacoeconomics of single-dose of ceftriaxone versus 3-day cefuroxime prophylaxis in patients undergoing gastric or colorectal resection.

METHODS

Three hundred and five consecutive patients with gastric or colorectal cancer from 5 medical centers were randomly divided into ceftriaxone group (n = 153, receiving intravenously 1 g ceftriaxone 0.5 - 1 h prior to operation only) and cefuroxime group (n = 152, receiving 0.75 g cefuroxime preoperatively and the same dose q8h for 3 d). The patients' intra- and postoperative status, adverse responses and infectious complications were observed and documented, and pharmacoeconomic parameters were analyzed.

RESULTS

The disease distribution, operative procedures and patients' conditions in the 2 groups were comparable. No adverse responses to the test antibiotics were observed. Postoperative infectious complications occurred in 7 cases in the ceftriaxone group (4.58%) and 14 cases in the cefuroxime group (9.21%), respectively (P = 0.992), among which, 12 cases were surgical site infections (incisional, intra-abdominal): 2 cases in the ceftriaxone group (1.31%), and 10 cases in the cefuroxime group (6.58%), (chi(2) = 5.607, P = 0.018). The direct cost related to prevention and treatment of surgical site infections was 283.5 RMB in the ceftriaxone group and 811.1 RMB in the cefuroxime group (Z = 14.51, P = 0.000).

CONCLUSION

Both ceftriaxone and cefuroxime are safe and effective for prevention of surgical site infections. Single-dose ceftriaxone prophylaxis is sufficient for gastric and colorectal operations, with a better cost-effectiveness ratio.

Authors+Show Affiliations

Department of General Surgery, 304th Hospital of People's Liberation Army, Beijing 100037, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

chi

PubMed ID

12892594

Citation

Li, Zhan-liang, et al. "[Single-dose Ceftriaxone Versus Multiple-dose Cefuroxime for Prophylaxis of Surgical Site Infection]." Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], vol. 41, no. 5, 2003, pp. 372-4.
Li ZL, Tong SX, Yu BM, et al. [Single-dose ceftriaxone versus multiple-dose cefuroxime for prophylaxis of surgical site infection]. Zhonghua Wai Ke Za Zhi. 2003;41(5):372-4.
Li, Z. L., Tong, S. X., Yu, B. M., Tang, W. S., Wu, Z. Y., Wang, S. B., Wu, Y. F., Lu, W. Q., Luo, M., & Wang, J. (2003). [Single-dose ceftriaxone versus multiple-dose cefuroxime for prophylaxis of surgical site infection]. Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery], 41(5), 372-4.
Li ZL, et al. [Single-dose Ceftriaxone Versus Multiple-dose Cefuroxime for Prophylaxis of Surgical Site Infection]. Zhonghua Wai Ke Za Zhi. 2003;41(5):372-4. PubMed PMID: 12892594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Single-dose ceftriaxone versus multiple-dose cefuroxime for prophylaxis of surgical site infection]. AU - Li,Zhan-liang, AU - Tong,Sai-xiong, AU - Yu,Bao-ming, AU - Tang,Wei-song, AU - Wu,Zhi-yong, AU - Wang,Shi-bin, AU - Wu,Yu-fei, AU - Lu,Wei-qi, AU - Luo,Meng, AU - Wang,Jian, PY - 2003/8/2/pubmed PY - 2008/12/23/medline PY - 2003/8/2/entrez SP - 372 EP - 4 JF - Zhonghua wai ke za zhi [Chinese journal of surgery] JO - Zhonghua Wai Ke Za Zhi VL - 41 IS - 5 N2 - OBJECTIVE: To compare the effects and pharmacoeconomics of single-dose of ceftriaxone versus 3-day cefuroxime prophylaxis in patients undergoing gastric or colorectal resection. METHODS: Three hundred and five consecutive patients with gastric or colorectal cancer from 5 medical centers were randomly divided into ceftriaxone group (n = 153, receiving intravenously 1 g ceftriaxone 0.5 - 1 h prior to operation only) and cefuroxime group (n = 152, receiving 0.75 g cefuroxime preoperatively and the same dose q8h for 3 d). The patients' intra- and postoperative status, adverse responses and infectious complications were observed and documented, and pharmacoeconomic parameters were analyzed. RESULTS: The disease distribution, operative procedures and patients' conditions in the 2 groups were comparable. No adverse responses to the test antibiotics were observed. Postoperative infectious complications occurred in 7 cases in the ceftriaxone group (4.58%) and 14 cases in the cefuroxime group (9.21%), respectively (P = 0.992), among which, 12 cases were surgical site infections (incisional, intra-abdominal): 2 cases in the ceftriaxone group (1.31%), and 10 cases in the cefuroxime group (6.58%), (chi(2) = 5.607, P = 0.018). The direct cost related to prevention and treatment of surgical site infections was 283.5 RMB in the ceftriaxone group and 811.1 RMB in the cefuroxime group (Z = 14.51, P = 0.000). CONCLUSION: Both ceftriaxone and cefuroxime are safe and effective for prevention of surgical site infections. Single-dose ceftriaxone prophylaxis is sufficient for gastric and colorectal operations, with a better cost-effectiveness ratio. SN - 0529-5815 UR - https://www.unboundmedicine.com/medline/citation/12892594/[Single_dose_ceftriaxone_versus_multiple_dose_cefuroxime_for_prophylaxis_of_surgical_site_infection]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-5815&year=2003&vol=41&issue=5&fpage=372 DB - PRIME DP - Unbound Medicine ER -