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Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment.
Biol Psychiatry 2003; 54(3):317-29BP

Abstract

This article reviews the rapidly accumulating literature on the relationship between mood disorders and diabetes mellitus. Recent studies have demonstrated that depression and its associated symptoms constitute a major risk factor in the development of type 2 diabetes and may accelerate the onset of diabetes complications. Since the mid-1980s, multiple longitudinal and cross-sectional studies have scrutinized the association of diabetes with depressive symptoms and major depression. Utilizing the search terms depressive disorders, psychiatry, diabetes, and pathophysiology in MEDLINE searches (1966-2003), this article reviews studies investigating pathophysiological alterations related to glucose intolerance and diabetes in depressed patients. The few randomized, controlled studies of treatment of depression in patients with diabetes are also described. Short-term treatment of depression in patients with diabetes improves their dysphoria and other signs and symptoms of depression. Future research will confirm whether response to psychotherapy and/or psychopharmacologic treatment improves glucose control, encourages compliance with diabetes treatment, and perhaps even increases longevity.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12893107

Citation

Musselman, Dominique L., et al. "Relationship of Depression to Diabetes Types 1 and 2: Epidemiology, Biology, and Treatment." Biological Psychiatry, vol. 54, no. 3, 2003, pp. 317-29.
Musselman DL, Betan E, Larsen H, et al. Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biol Psychiatry. 2003;54(3):317-29.
Musselman, D. L., Betan, E., Larsen, H., & Phillips, L. S. (2003). Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biological Psychiatry, 54(3), pp. 317-29.
Musselman DL, et al. Relationship of Depression to Diabetes Types 1 and 2: Epidemiology, Biology, and Treatment. Biol Psychiatry. 2003 Aug 1;54(3):317-29. PubMed PMID: 12893107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. AU - Musselman,Dominique L, AU - Betan,Ephi, AU - Larsen,Hannah, AU - Phillips,Lawrence S, PY - 2003/8/2/pubmed PY - 2003/9/27/medline PY - 2003/8/2/entrez SP - 317 EP - 29 JF - Biological psychiatry JO - Biol. Psychiatry VL - 54 IS - 3 N2 - This article reviews the rapidly accumulating literature on the relationship between mood disorders and diabetes mellitus. Recent studies have demonstrated that depression and its associated symptoms constitute a major risk factor in the development of type 2 diabetes and may accelerate the onset of diabetes complications. Since the mid-1980s, multiple longitudinal and cross-sectional studies have scrutinized the association of diabetes with depressive symptoms and major depression. Utilizing the search terms depressive disorders, psychiatry, diabetes, and pathophysiology in MEDLINE searches (1966-2003), this article reviews studies investigating pathophysiological alterations related to glucose intolerance and diabetes in depressed patients. The few randomized, controlled studies of treatment of depression in patients with diabetes are also described. Short-term treatment of depression in patients with diabetes improves their dysphoria and other signs and symptoms of depression. Future research will confirm whether response to psychotherapy and/or psychopharmacologic treatment improves glucose control, encourages compliance with diabetes treatment, and perhaps even increases longevity. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/12893107/Relationship_of_depression_to_diabetes_types_1_and_2:_epidemiology_biology_and_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006322303005699 DB - PRIME DP - Unbound Medicine ER -