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Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes.
Blood. 2003 Dec 01; 102(12):4107-14.Blood

Abstract

CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD25+ thymocytes did not produce cytokines, but most of them expressed surface CTLA-4 and transforming growth factor beta1 (TGF-beta1). Like CD4+CD25+, CD8+CD25+ thymocytes suppressed the proliferation of autologous CD25-T cells via a contact-dependent mechanism. The suppressive activity of CD8+CD25+ thymocytes was abrogated by a mixture of anti-CTLA-4 and anti-TGF-beta1 antibodies and it was mediated by their ability to inhibit the expression of the interleukin 2 receptor alpha chain on target T cells. These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells.

Authors+Show Affiliations

Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12893750

Citation

Cosmi, Lorenzo, et al. "Human CD8+CD25+ Thymocytes Share Phenotypic and Functional Features With CD4+CD25+ Regulatory Thymocytes." Blood, vol. 102, no. 12, 2003, pp. 4107-14.
Cosmi L, Liotta F, Lazzeri E, et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood. 2003;102(12):4107-14.
Cosmi, L., Liotta, F., Lazzeri, E., Francalanci, M., Angeli, R., Mazzinghi, B., Santarlasci, V., Manetti, R., Vanini, V., Romagnani, P., Maggi, E., Romagnani, S., & Annunziato, F. (2003). Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood, 102(12), 4107-14.
Cosmi L, et al. Human CD8+CD25+ Thymocytes Share Phenotypic and Functional Features With CD4+CD25+ Regulatory Thymocytes. Blood. 2003 Dec 1;102(12):4107-14. PubMed PMID: 12893750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. AU - Cosmi,Lorenzo, AU - Liotta,Francesco, AU - Lazzeri,Elena, AU - Francalanci,Michela, AU - Angeli,Roberta, AU - Mazzinghi,Benedetta, AU - Santarlasci,Veronica, AU - Manetti,Roberto, AU - Vanini,Vittorio, AU - Romagnani,Paola, AU - Maggi,Enrico, AU - Romagnani,Sergio, AU - Annunziato,Francesco, Y1 - 2003/07/31/ PY - 2003/8/2/pubmed PY - 2004/1/15/medline PY - 2003/8/2/entrez SP - 4107 EP - 14 JF - Blood JO - Blood VL - 102 IS - 12 N2 - CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD25+ thymocytes did not produce cytokines, but most of them expressed surface CTLA-4 and transforming growth factor beta1 (TGF-beta1). Like CD4+CD25+, CD8+CD25+ thymocytes suppressed the proliferation of autologous CD25-T cells via a contact-dependent mechanism. The suppressive activity of CD8+CD25+ thymocytes was abrogated by a mixture of anti-CTLA-4 and anti-TGF-beta1 antibodies and it was mediated by their ability to inhibit the expression of the interleukin 2 receptor alpha chain on target T cells. These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/12893750/Human_CD8+CD25+_thymocytes_share_phenotypic_and_functional_features_with_CD4+CD25+_regulatory_thymocytes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/2003-04-1320 DB - PRIME DP - Unbound Medicine ER -