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Hypopigmented mycosis fungoides in Caucasian patients: a clinicopathologic study of 7 cases.
J Am Acad Dermatol. 2003 Aug; 49(2):264-70.JA

Abstract

BACKGROUND

Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned or Asian patients, particularly children. Only 9 cases in Caucasian patients have been reported in the literature so far.

OBSERVATION

We describe 7 Caucasian patients (2 children and 5 adults) with hypopigmented MF. Histologic examination confirmed the diagnosis in all cases. The phenotype of neoplastic lymphocytes was T helper in 4 cases and T suppressor in 3 (2 of them children). Monoclonality of the T lymphocytes could be detected in hypopigmented lesions in all 7 cases with the use of a polymerase chain reaction technique. In 4 patients, polymerase chain reaction analysis of T-cell receptor-gene rearrangement after laser-based microdissection of the specimen revealed that the monoclonal population of T lymphocytes was confined mainly to the epidermis.

CONCLUSION

Hypopigmented lesions of MF can be observed in Caucasian patients. Children affected by MF often present with this rare clinical variant of the disease. Persistent or unusual hypopigmented lesions should be subjected to biopsy to avoid delay in the diagnosis of MF, especially in children.

Authors+Show Affiliations

Department of Dermatology, University of Graz, University of Pavia, Rome.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12894075

Citation

Ardigó, Marco, et al. "Hypopigmented Mycosis Fungoides in Caucasian Patients: a Clinicopathologic Study of 7 Cases." Journal of the American Academy of Dermatology, vol. 49, no. 2, 2003, pp. 264-70.
Ardigó M, Borroni G, Muscardin L, et al. Hypopigmented mycosis fungoides in Caucasian patients: a clinicopathologic study of 7 cases. J Am Acad Dermatol. 2003;49(2):264-70.
Ardigó, M., Borroni, G., Muscardin, L., Kerl, H., & Cerroni, L. (2003). Hypopigmented mycosis fungoides in Caucasian patients: a clinicopathologic study of 7 cases. Journal of the American Academy of Dermatology, 49(2), 264-70.
Ardigó M, et al. Hypopigmented Mycosis Fungoides in Caucasian Patients: a Clinicopathologic Study of 7 Cases. J Am Acad Dermatol. 2003;49(2):264-70. PubMed PMID: 12894075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypopigmented mycosis fungoides in Caucasian patients: a clinicopathologic study of 7 cases. AU - Ardigó,Marco, AU - Borroni,Giovanni, AU - Muscardin,Luca, AU - Kerl,Helmut, AU - Cerroni,Lorenzo, PY - 2003/8/2/pubmed PY - 2004/1/24/medline PY - 2003/8/2/entrez SP - 264 EP - 70 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 49 IS - 2 N2 - BACKGROUND: Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned or Asian patients, particularly children. Only 9 cases in Caucasian patients have been reported in the literature so far. OBSERVATION: We describe 7 Caucasian patients (2 children and 5 adults) with hypopigmented MF. Histologic examination confirmed the diagnosis in all cases. The phenotype of neoplastic lymphocytes was T helper in 4 cases and T suppressor in 3 (2 of them children). Monoclonality of the T lymphocytes could be detected in hypopigmented lesions in all 7 cases with the use of a polymerase chain reaction technique. In 4 patients, polymerase chain reaction analysis of T-cell receptor-gene rearrangement after laser-based microdissection of the specimen revealed that the monoclonal population of T lymphocytes was confined mainly to the epidermis. CONCLUSION: Hypopigmented lesions of MF can be observed in Caucasian patients. Children affected by MF often present with this rare clinical variant of the disease. Persistent or unusual hypopigmented lesions should be subjected to biopsy to avoid delay in the diagnosis of MF, especially in children. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/12894075/Hypopigmented_mycosis_fungoides_in_Caucasian_patients:_a_clinicopathologic_study_of_7_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190962203009071 DB - PRIME DP - Unbound Medicine ER -