Tags

Type your tag names separated by a space and hit enter

The somatostatin sst2A receptor in the rat trigeminal ganglion.
Neuroscience. 2003; 120(3):807-13.N

Abstract

Immunohistochemistry for the somatostatin sst2A receptor was performed on the rat trigeminal ganglion to know its function in the trigeminal nervous system. The immunoreactivity was detected in 9.4% of primary sensory neurons in the ganglion. These neurons were small to medium-sized (range=106.5-1123.2 microm(2); mean+/-S.D.=506.3+/-213.2 microm(2)) and predominantly located in the rostromedial part of the ophthalmo-maxillary division. They were also immunoreactive for calcitonin gene-related peptide and the vanilloid receptor subtype 1. In addition, 13.7% of trigeminal neurons which were retrogradely traced with fluorogold from the nasal mucosa exhibited sst2A receptor-immmunoreactivity. Trigeminal neurons which innervated the facial skin and tooth pulp were devoid of the immunoreactivity. In the brainstem trigeminal sensory nuclear complex, both the neuronal cell body and the neuropil exhibited sst2A receptor-immunoreactivity in the superficial medullary dorsal horn.The present study indicates that sst2A receptor-immunoreactive trigeminal nociceptors innervate the nasal mucosa. They may project to the superficial laminae of the medullary dorsal horn.

Authors+Show Affiliations

Department of Oral Function and Anatomy, and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.hiroichi@md.okayama-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12895520

Citation

Ichikawa, H, et al. "The Somatostatin sst2A Receptor in the Rat Trigeminal Ganglion." Neuroscience, vol. 120, no. 3, 2003, pp. 807-13.
Ichikawa H, Schulz S, Höllt V, et al. The somatostatin sst2A receptor in the rat trigeminal ganglion. Neuroscience. 2003;120(3):807-13.
Ichikawa, H., Schulz, S., Höllt, V., & Sugimoto, T. (2003). The somatostatin sst2A receptor in the rat trigeminal ganglion. Neuroscience, 120(3), 807-13.
Ichikawa H, et al. The Somatostatin sst2A Receptor in the Rat Trigeminal Ganglion. Neuroscience. 2003;120(3):807-13. PubMed PMID: 12895520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The somatostatin sst2A receptor in the rat trigeminal ganglion. AU - Ichikawa,H, AU - Schulz,S, AU - Höllt,V, AU - Sugimoto,T, PY - 2003/8/5/pubmed PY - 2003/12/5/medline PY - 2003/8/5/entrez SP - 807 EP - 13 JF - Neuroscience JO - Neuroscience VL - 120 IS - 3 N2 - Immunohistochemistry for the somatostatin sst2A receptor was performed on the rat trigeminal ganglion to know its function in the trigeminal nervous system. The immunoreactivity was detected in 9.4% of primary sensory neurons in the ganglion. These neurons were small to medium-sized (range=106.5-1123.2 microm(2); mean+/-S.D.=506.3+/-213.2 microm(2)) and predominantly located in the rostromedial part of the ophthalmo-maxillary division. They were also immunoreactive for calcitonin gene-related peptide and the vanilloid receptor subtype 1. In addition, 13.7% of trigeminal neurons which were retrogradely traced with fluorogold from the nasal mucosa exhibited sst2A receptor-immmunoreactivity. Trigeminal neurons which innervated the facial skin and tooth pulp were devoid of the immunoreactivity. In the brainstem trigeminal sensory nuclear complex, both the neuronal cell body and the neuropil exhibited sst2A receptor-immunoreactivity in the superficial medullary dorsal horn.The present study indicates that sst2A receptor-immunoreactive trigeminal nociceptors innervate the nasal mucosa. They may project to the superficial laminae of the medullary dorsal horn. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/12895520/The_somatostatin_sst2A_receptor_in_the_rat_trigeminal_ganglion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306452203003646 DB - PRIME DP - Unbound Medicine ER -