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Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus.
J Am Coll Nutr. 2003 Aug; 22(4):316-21.JA

Abstract

OBJECTIVE

To determine the effects of zinc (Zn) supplementation on oxidative stress in persons with type 2 diabetes mellitus (type 2 DM).

DESIGN

Tunisian adult subjects with HbA1c >7.5% were supplemented for six months with 30 mg/day of Zn as Zn gluconate or placebo. The effects of supplementation on plasma zinc (Zn), copper (Cu), urinary Zn, plasma thiobarbituric acid reactive substances (TBARS), Cu-Zn superoxide dismutase (SOD) and glutathione peroxidase activities (GPX) in red blood cells, blood lipids and lipoproteins, HbA1c and fasting glucose were measured at the beginning of the study and after three and six months.

RESULTS

At the beginning of the study, more than 30% of the subjects exhibited plasma Zn values less than the normal minimum of 10.7 micro mol/L, whereas levels of plasma Cu and antioxidant RBC Cu-Zn SOD and GPx enzyme activities were in the normal ranges. Oxidative stress, monitored by plasma TBARS, was increased in individuals with diabetes compared with healthy Tunisian subjects (3.32 +/- 0.05 micro mol/L vs. 2.08 +/- 0.04 micro mol/L) and an inverse correlation was found between Zn plasma levels and plasma TBARS. After three and six months of Zn supplementation, all of the subjects exhibited plasma Zn values greater than 10.7 micro mol/L. There was a decrease of plasma TBARS in Zn supplemented group after six months (15%) with no significant changes in the placebo group. Supplementation did not alter significantly HbA1c nor glucose homeostasis. No adverse effects of Zn supplementation were observed on Cu status or HDL cholesterol.

CONCLUSIONS

These data suggest the potential beneficial antioxidant effects of Zn supplementation in persons with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in persons with diabetes.

Authors+Show Affiliations

Roussel AM
LBSO, Oxidative Stress Laboratory, Joseph Fourier University, Grenoble, France.
Kerkeni A
No affiliation info available
Zouari N
No affiliation info available
Mahjoub S
No affiliation info available
Matheau JM
No affiliation info available
Anderson RA
No affiliation info available

MeSH

AntioxidantsCopperDiabetes Mellitus, Type 2Dietary SupplementsDouble-Blind MethodFemaleGlutathione PeroxidaseGlycated HemoglobinHumansMaleMiddle AgedOxidation-ReductionOxidative StressSeleniumSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesTunisiaZinc

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12897047

Citation

Roussel, Anne-Marie, et al. "Antioxidant Effects of Zinc Supplementation in Tunisians With Type 2 Diabetes Mellitus." Journal of the American College of Nutrition, vol. 22, no. 4, 2003, pp. 316-21.
Roussel AM, Kerkeni A, Zouari N, et al. Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. J Am Coll Nutr. 2003;22(4):316-21.
Roussel, A. M., Kerkeni, A., Zouari, N., Mahjoub, S., Matheau, J. M., & Anderson, R. A. (2003). Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. Journal of the American College of Nutrition, 22(4), 316-21.
Roussel AM, et al. Antioxidant Effects of Zinc Supplementation in Tunisians With Type 2 Diabetes Mellitus. J Am Coll Nutr. 2003;22(4):316-21. PubMed PMID: 12897047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. AU - Roussel,Anne-Marie, AU - Kerkeni,Abdelhamid, AU - Zouari,Nouri, AU - Mahjoub,Sylvia, AU - Matheau,Jean-Marc, AU - Anderson,Richard A, PY - 2003/8/5/pubmed PY - 2003/12/12/medline PY - 2003/8/5/entrez SP - 316 EP - 21 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 22 IS - 4 N2 - OBJECTIVE: To determine the effects of zinc (Zn) supplementation on oxidative stress in persons with type 2 diabetes mellitus (type 2 DM). DESIGN: Tunisian adult subjects with HbA1c >7.5% were supplemented for six months with 30 mg/day of Zn as Zn gluconate or placebo. The effects of supplementation on plasma zinc (Zn), copper (Cu), urinary Zn, plasma thiobarbituric acid reactive substances (TBARS), Cu-Zn superoxide dismutase (SOD) and glutathione peroxidase activities (GPX) in red blood cells, blood lipids and lipoproteins, HbA1c and fasting glucose were measured at the beginning of the study and after three and six months. RESULTS: At the beginning of the study, more than 30% of the subjects exhibited plasma Zn values less than the normal minimum of 10.7 micro mol/L, whereas levels of plasma Cu and antioxidant RBC Cu-Zn SOD and GPx enzyme activities were in the normal ranges. Oxidative stress, monitored by plasma TBARS, was increased in individuals with diabetes compared with healthy Tunisian subjects (3.32 +/- 0.05 micro mol/L vs. 2.08 +/- 0.04 micro mol/L) and an inverse correlation was found between Zn plasma levels and plasma TBARS. After three and six months of Zn supplementation, all of the subjects exhibited plasma Zn values greater than 10.7 micro mol/L. There was a decrease of plasma TBARS in Zn supplemented group after six months (15%) with no significant changes in the placebo group. Supplementation did not alter significantly HbA1c nor glucose homeostasis. No adverse effects of Zn supplementation were observed on Cu status or HDL cholesterol. CONCLUSIONS: These data suggest the potential beneficial antioxidant effects of Zn supplementation in persons with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in persons with diabetes. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/12897047/Antioxidant_effects_of_zinc_supplementation_in_Tunisians_with_type_2_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -