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Peripheral primitive neuroectodermal tumor after radiotherapy.

Abstract

A 41-year-old man had a peripheral neuroectodermal tumor develop at the distal third of the fibula 4 years after radiotherapy for relapsed villonodular synovitis. This type of sarcoma usually is classified into the heterogeneic group of small round-cell bone tumors as a subdivision of Ewing's sarcomas. The immuno-staining positivity of the neoplastic cells for the neuron-specific enolase allowed the authors to make the diagnosis of a tumor with neuroectodermal origin. When the histologic study confirmed the diagnosis, the patient was treated with chemotherapy, surgical excision of the tumor, and adjuvant radiotherapy. Radiotherapy is thought to be involved in the genesis of osteogenic sarcomas as it has been shown in several reports, but there is no evidence in the literature of a peripheral neuroectodermal tumor developing after radiotherapy.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Hospital Clínico San Carlos, Martin Lagos s/n, 28040 Madrid, Spain. juan_luis_cebrian@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12897617

Citation

Cebrián, Juan L., et al. "Peripheral Primitive Neuroectodermal Tumor After Radiotherapy." Clinical Orthopaedics and Related Research, 2003, pp. 255-60.
Cebrián JL, Ibarzabal A, Garcia-Crespo R, et al. Peripheral primitive neuroectodermal tumor after radiotherapy. Clin Orthop Relat Res. 2003.
Cebrián, J. L., Ibarzabal, A., Garcia-Crespo, R., Marco, F., Ortega, L., & López-Durán, L. (2003). Peripheral primitive neuroectodermal tumor after radiotherapy. Clinical Orthopaedics and Related Research, (413), 255-60.
Cebrián JL, et al. Peripheral Primitive Neuroectodermal Tumor After Radiotherapy. Clin Orthop Relat Res. 2003;(413)255-60. PubMed PMID: 12897617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral primitive neuroectodermal tumor after radiotherapy. AU - Cebrián,Juan L, AU - Ibarzabal,Aitor, AU - Garcia-Crespo,Rodrigo, AU - Marco,Fernando, AU - Ortega,Luis, AU - López-Durán,Luis, PY - 2003/8/5/pubmed PY - 2003/8/30/medline PY - 2003/8/5/entrez SP - 255 EP - 60 JF - Clinical orthopaedics and related research JO - Clin. Orthop. Relat. Res. IS - 413 N2 - A 41-year-old man had a peripheral neuroectodermal tumor develop at the distal third of the fibula 4 years after radiotherapy for relapsed villonodular synovitis. This type of sarcoma usually is classified into the heterogeneic group of small round-cell bone tumors as a subdivision of Ewing's sarcomas. The immuno-staining positivity of the neoplastic cells for the neuron-specific enolase allowed the authors to make the diagnosis of a tumor with neuroectodermal origin. When the histologic study confirmed the diagnosis, the patient was treated with chemotherapy, surgical excision of the tumor, and adjuvant radiotherapy. Radiotherapy is thought to be involved in the genesis of osteogenic sarcomas as it has been shown in several reports, but there is no evidence in the literature of a peripheral neuroectodermal tumor developing after radiotherapy. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/12897617/Peripheral_primitive_neuroectodermal_tumor_after_radiotherapy_ L2 - http://Insights.ovid.com/pubmed?pmid=12897617 DB - PRIME DP - Unbound Medicine ER -