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Phytoestrogens: recent developments.
Planta Med 2003; 69(7):589-99PM

Abstract

Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like biological activity. Based on their chemical structure, phytoestrogens can be classified into four main groups, i. e., isoflavonoids, flavonoids, stilbenes, and lignans. For each group, the chemistry, dietary sources and biotransformation of the most interesting compounds will be discussed. Since phytoestrogens are structurally very similar to the estrogen 17beta-estradiol, they may exhibit selective estrogen receptor modulating activities. Therefore, special attention will be given to the hormonal effects of various isoflavonoids, including genistein, daidzein, coumestrol and equol, several prenylated flavonoids, especially 8-prenylnaringenin, and the stilbene resveratrol. Furthermore, their non-hormonal effects will be discussed briefly. Finally, the latest developments on the potential protective properties of phytoestrogens and phytoestrogen-containing foods against hormone-dependent breast and prostate cancers and cardiovascular diseases, and as estrogen replacement therapy for postmenopausal women will be discussed.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12898412

Citation

Cos, Paul, et al. "Phytoestrogens: Recent Developments." Planta Medica, vol. 69, no. 7, 2003, pp. 589-99.
Cos P, De Bruyne T, Apers S, et al. Phytoestrogens: recent developments. Planta Med. 2003;69(7):589-99.
Cos, P., De Bruyne, T., Apers, S., Vanden Berghe, D., Pieters, L., & Vlietinck, A. J. (2003). Phytoestrogens: recent developments. Planta Medica, 69(7), pp. 589-99.
Cos P, et al. Phytoestrogens: Recent Developments. Planta Med. 2003;69(7):589-99. PubMed PMID: 12898412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytoestrogens: recent developments. AU - Cos,Paul, AU - De Bruyne,Tess, AU - Apers,Sandra, AU - Vanden Berghe,Dirk, AU - Pieters,Luc, AU - Vlietinck,Arnold J, PY - 2003/8/5/pubmed PY - 2003/10/8/medline PY - 2003/8/5/entrez SP - 589 EP - 99 JF - Planta medica JO - Planta Med. VL - 69 IS - 7 N2 - Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like biological activity. Based on their chemical structure, phytoestrogens can be classified into four main groups, i. e., isoflavonoids, flavonoids, stilbenes, and lignans. For each group, the chemistry, dietary sources and biotransformation of the most interesting compounds will be discussed. Since phytoestrogens are structurally very similar to the estrogen 17beta-estradiol, they may exhibit selective estrogen receptor modulating activities. Therefore, special attention will be given to the hormonal effects of various isoflavonoids, including genistein, daidzein, coumestrol and equol, several prenylated flavonoids, especially 8-prenylnaringenin, and the stilbene resveratrol. Furthermore, their non-hormonal effects will be discussed briefly. Finally, the latest developments on the potential protective properties of phytoestrogens and phytoestrogen-containing foods against hormone-dependent breast and prostate cancers and cardiovascular diseases, and as estrogen replacement therapy for postmenopausal women will be discussed. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12898412/Phytoestrogens:_recent_developments_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-41122 DB - PRIME DP - Unbound Medicine ER -