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Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis: a meta-analysis of 6 Nordic cohorts with 73,000 patients.
Acta Orthop Scand. 2003 Jun; 74(3):351-60.AO

Abstract

3 Nordic cohorts of total hip (THA) and total knee arthroplasty (TKA) in patients operated on for primary osteoarthrosis during 1967-1995 were partly adapted and combined for meta-analysis. THA was performed in 49,000 patients and TKA in 24,000 totaling 497,000 person years. The mean and maximum follow-up times were 6.8 and 30 years, respectively. Standardized incidence ratios (SIRs) with 95% confidence intervals (95% CI) were calculated for the observed and expected number of cancers. The expected numbers were based on national incidence rates. The overall SIRs as well as the site-specific ones were similar in the THA and TKA patients. The observed number of cancers at all sites was 7,639 and the expected one was 8,202 (SIR 0.93, 95% CI 0.91-0.95). The SIRs for lung cancer (0.69, 0.64-0.75) and laryngeal cancer (0.64, 0.44-0.92) were reduced. The incidence was also low for cancers of the stomach (SIR 0.76, 0.67-0.84), colon (SIR 0.86, 0.79-0.93) and rectum (SIR 0.89, 0.80-0.98). Among TKA patients, the only increases in SIRs were seen in cancers of the endometrium (SIR 1.36, 1.05-1.74), prostate (SIR 1.19, 1.02-1.38) and, among both THA and TKA patients, in skin melanoma (combined SIR 1.21, 1.03-1.41).

Authors+Show Affiliations

Visuri T
Department of Surgery, Central Military Hospital, P.O. Box 50, FI-00301 Helsinki, Finland. tuomo.visuri@helsinki.fi
Pukkala E
No affiliation info available
Pulkkinen P
No affiliation info available
Paavolainen P
No affiliation info available

MeSH

AgedArthroplasty, Replacement, HipArthroplasty, Replacement, KneeConfounding Factors, EpidemiologicDenmarkFemaleFinlandFollow-Up StudiesHumansIncidenceLife ExpectancyLife StyleMaleMiddle AgedNeoplasmsOsteoarthritis, HipOsteoarthritis, KneePopulation SurveillanceRegistriesRisk AssessmentRisk FactorsSwedenTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12899558

Citation

Visuri, Tuomo, et al. "Decreased Cancer Risk in Patients Who Have Been Operated On With Total Hip and Knee Arthroplasty for Primary Osteoarthrosis: a Meta-analysis of 6 Nordic Cohorts With 73,000 Patients." Acta Orthopaedica Scandinavica, vol. 74, no. 3, 2003, pp. 351-60.
Visuri T, Pukkala E, Pulkkinen P, et al. Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis: a meta-analysis of 6 Nordic cohorts with 73,000 patients. Acta Orthop Scand. 2003;74(3):351-60.
Visuri, T., Pukkala, E., Pulkkinen, P., & Paavolainen, P. (2003). Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis: a meta-analysis of 6 Nordic cohorts with 73,000 patients. Acta Orthopaedica Scandinavica, 74(3), 351-60.
Visuri T, et al. Decreased Cancer Risk in Patients Who Have Been Operated On With Total Hip and Knee Arthroplasty for Primary Osteoarthrosis: a Meta-analysis of 6 Nordic Cohorts With 73,000 Patients. Acta Orthop Scand. 2003;74(3):351-60. PubMed PMID: 12899558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis: a meta-analysis of 6 Nordic cohorts with 73,000 patients. AU - Visuri,Tuomo, AU - Pukkala,Eero, AU - Pulkkinen,Pekka, AU - Paavolainen,Pekka, PY - 2003/8/6/pubmed PY - 2003/8/22/medline PY - 2003/8/6/entrez SP - 351 EP - 60 JF - Acta orthopaedica Scandinavica JO - Acta Orthop Scand VL - 74 IS - 3 N2 - 3 Nordic cohorts of total hip (THA) and total knee arthroplasty (TKA) in patients operated on for primary osteoarthrosis during 1967-1995 were partly adapted and combined for meta-analysis. THA was performed in 49,000 patients and TKA in 24,000 totaling 497,000 person years. The mean and maximum follow-up times were 6.8 and 30 years, respectively. Standardized incidence ratios (SIRs) with 95% confidence intervals (95% CI) were calculated for the observed and expected number of cancers. The expected numbers were based on national incidence rates. The overall SIRs as well as the site-specific ones were similar in the THA and TKA patients. The observed number of cancers at all sites was 7,639 and the expected one was 8,202 (SIR 0.93, 95% CI 0.91-0.95). The SIRs for lung cancer (0.69, 0.64-0.75) and laryngeal cancer (0.64, 0.44-0.92) were reduced. The incidence was also low for cancers of the stomach (SIR 0.76, 0.67-0.84), colon (SIR 0.86, 0.79-0.93) and rectum (SIR 0.89, 0.80-0.98). Among TKA patients, the only increases in SIRs were seen in cancers of the endometrium (SIR 1.36, 1.05-1.74), prostate (SIR 1.19, 1.02-1.38) and, among both THA and TKA patients, in skin melanoma (combined SIR 1.21, 1.03-1.41). SN - 0001-6470 UR - https://www.unboundmedicine.com/medline/citation/12899558/Decreased_cancer_risk_in_patients_who_have_been_operated_on_with_total_hip_and_knee_arthroplasty_for_primary_osteoarthrosis:_a_meta_analysis_of_6_Nordic_cohorts_with_73000_patients_ DB - PRIME DP - Unbound Medicine ER -