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[Severe acute respiratory syndrome in 78 patients: a retrospective study].
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Jun; 26(6):334-8.ZJ

Abstract

OBJECTIVE

To analyze the clinical features of severe acute respiratory syndrome (SARS) and the diagnosis and treatment of the disease.

METHODS

Seventy-eight patients with SARS referred to the Guangzhou Institute of Respiratory Diseases (GIRD), China from December 22, 2002 to March 2003 were studied retrospectively. The data reviewed included those of clinical manifestations, laboratory investigation and roentgenology.

RESULTS

The patients consisted of 42 men and 36 women, aged 20 - 75 years (mean 37.5 +/- 11.6 years), including 44 infected health-care professionals. Clinical symptoms of these patients were fever (100%), coughing (88%), and dyspnea (80%). Routine blood test revealed WBCs <4.0 x 10(9)/L in 12 patients (15%), (4.0 -10.0) x 10(9)/L in 49 (63%), and over 10.0 x 10(9)/L in 17 (22%) [average (7.6 +/- 5.0) x 10(9)/L]. The level of neutrophilic granulocyte was 0.75 +/- 0.13 and that of lymphocyte was 0.18 +/- 0.11. Chest X-ray and CT scanning revealed changes related to pneumonia. The transmission of the disease was likely via close contact with contagious droplets. The prevalences of acute lung injury (ALI,37 patients) and acute respiratory distress syndrome (ARDS, 21 of the 37 patients) were considerably high among the patients. Seven patients who developed ARDS complicated with MODS died.

CONCLUSIONS

A history of close contact, fever, X-ray signs of pneumonia and normal or lowered WBC counts are favorable for the diagnosis of SARS. Recognition of ALI as the important index for critical SARS and comprehensive supportive management are of paramount importance in decreasing the mortality of patients with SARS.

Authors+Show Affiliations

Guangzhou Institute of Respiratory Diseases, Guangzhou 510120, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12899764

Citation

Xiao, Zheng-lun, et al. "[Severe Acute Respiratory Syndrome in 78 Patients: a Retrospective Study]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 26, no. 6, 2003, pp. 334-8.
Xiao ZL, Li YM, Chen RC, et al. [Severe acute respiratory syndrome in 78 patients: a retrospective study]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(6):334-8.
Xiao, Z. L., Li, Y. M., Chen, R. C., Li, S. Y., Zhong, S. Q., He, G. Q., Nong, L. B., Gu, Y. Y., & Zhong, N. S. (2003). [Severe acute respiratory syndrome in 78 patients: a retrospective study]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 26(6), 334-8.
Xiao ZL, et al. [Severe Acute Respiratory Syndrome in 78 Patients: a Retrospective Study]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(6):334-8. PubMed PMID: 12899764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Severe acute respiratory syndrome in 78 patients: a retrospective study]. AU - Xiao,Zheng-lun, AU - Li,Yi-min, AU - Chen,Rong-chang, AU - Li,Shi-yue, AU - Zhong,Shu-qing, AU - He,Guo-qing, AU - Nong,Ling-bo, AU - Gu,Ying-ying, AU - Zhong,Nan-shan, PY - 2003/8/6/pubmed PY - 2003/11/8/medline PY - 2003/8/6/entrez SP - 334 EP - 8 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 26 IS - 6 N2 - OBJECTIVE: To analyze the clinical features of severe acute respiratory syndrome (SARS) and the diagnosis and treatment of the disease. METHODS: Seventy-eight patients with SARS referred to the Guangzhou Institute of Respiratory Diseases (GIRD), China from December 22, 2002 to March 2003 were studied retrospectively. The data reviewed included those of clinical manifestations, laboratory investigation and roentgenology. RESULTS: The patients consisted of 42 men and 36 women, aged 20 - 75 years (mean 37.5 +/- 11.6 years), including 44 infected health-care professionals. Clinical symptoms of these patients were fever (100%), coughing (88%), and dyspnea (80%). Routine blood test revealed WBCs <4.0 x 10(9)/L in 12 patients (15%), (4.0 -10.0) x 10(9)/L in 49 (63%), and over 10.0 x 10(9)/L in 17 (22%) [average (7.6 +/- 5.0) x 10(9)/L]. The level of neutrophilic granulocyte was 0.75 +/- 0.13 and that of lymphocyte was 0.18 +/- 0.11. Chest X-ray and CT scanning revealed changes related to pneumonia. The transmission of the disease was likely via close contact with contagious droplets. The prevalences of acute lung injury (ALI,37 patients) and acute respiratory distress syndrome (ARDS, 21 of the 37 patients) were considerably high among the patients. Seven patients who developed ARDS complicated with MODS died. CONCLUSIONS: A history of close contact, fever, X-ray signs of pneumonia and normal or lowered WBC counts are favorable for the diagnosis of SARS. Recognition of ALI as the important index for critical SARS and comprehensive supportive management are of paramount importance in decreasing the mortality of patients with SARS. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/12899764/[Severe_acute_respiratory_syndrome_in_78_patients:_a_retrospective_study]_ DB - PRIME DP - Unbound Medicine ER -