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[Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance].
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Jun; 26(6):343-6.ZJ

Abstract

OBJECTIVE

To investigate the changes of subsets of blood T lymphocyte in patients with severe acute respiratory syndrome (SARS) and their clinical significance.

METHODS

Subsets of blood T lymphocyte in 93 patients with SARS were detected by flow cytometer. The patients comprised 40 men and 53 women, aged 17 - 88 years (average 44 years). The results detected in 64 normal subjects and 50 patients with AIDS served as controls.

RESULTS

The numbers of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes all significantly decreased in acute phase of SARS patients compared with those in normal persons. Their findings was different from what we observed in patients with AIDS who had decreased CD(4)(+), but increased CD(8)(+) counts. The counts of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes decreased more apparently in patients with critical SARS. All the five patients who died had CD(4)(+) counts less than 200/microl. As the patients' conditions improved, the counts of CD(3)(+), CD(4)(+), and CD(8)(+) gradually returned to normal.

CONCLUSION

The patients with SARS were found having damage of cellular immunity markedly.

Authors+Show Affiliations

Guangzhou 8th people's Hospital, Guangzhou 510060, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12899766

Citation

Yin, Chi-biao, et al. "[Measurement of Subsets of Blood T Lymphocyte in 93 Patients With Severe Acute Respiratory Syndrome and Its Clinical Significance]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 26, no. 6, 2003, pp. 343-6.
Yin CB, Zhang FC, Tang XP, et al. [Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(6):343-6.
Yin, C. B., Zhang, F. C., Tang, X. P., Chen, W. L., Chen, Y. Q., Wang, J., & Jia, W. D. (2003). [Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 26(6), 343-6.
Yin CB, et al. [Measurement of Subsets of Blood T Lymphocyte in 93 Patients With Severe Acute Respiratory Syndrome and Its Clinical Significance]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(6):343-6. PubMed PMID: 12899766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance]. AU - Yin,Chi-biao, AU - Zhang,Fu-chun, AU - Tang,Xiao-ping, AU - Chen,Wei-lie, AU - Chen,Yan-qing, AU - Wang,Jian, AU - Jia,Wei-dong, PY - 2003/8/6/pubmed PY - 2003/11/8/medline PY - 2003/8/6/entrez SP - 343 EP - 6 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 26 IS - 6 N2 - OBJECTIVE: To investigate the changes of subsets of blood T lymphocyte in patients with severe acute respiratory syndrome (SARS) and their clinical significance. METHODS: Subsets of blood T lymphocyte in 93 patients with SARS were detected by flow cytometer. The patients comprised 40 men and 53 women, aged 17 - 88 years (average 44 years). The results detected in 64 normal subjects and 50 patients with AIDS served as controls. RESULTS: The numbers of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes all significantly decreased in acute phase of SARS patients compared with those in normal persons. Their findings was different from what we observed in patients with AIDS who had decreased CD(4)(+), but increased CD(8)(+) counts. The counts of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes decreased more apparently in patients with critical SARS. All the five patients who died had CD(4)(+) counts less than 200/microl. As the patients' conditions improved, the counts of CD(3)(+), CD(4)(+), and CD(8)(+) gradually returned to normal. CONCLUSION: The patients with SARS were found having damage of cellular immunity markedly. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/12899766/[Measurement_of_subsets_of_blood_T_lymphocyte_in_93_patients_with_severe_acute_respiratory_syndrome_and_its_clinical_significance]_ L2 - https://antibodies.cancer.gov/detail/CPTC-CD4-1 DB - PRIME DP - Unbound Medicine ER -