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[Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia].
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Jun; 26(6):350-3.ZJ

Abstract

OBJECTIVE

To study the distribution, the expression and the significance of TGF-beta(1), b-FGF, IL-8, IL-13 and IFN-gamma in different lung tissue compartments in usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) and nonspecific interstitial pneumonia (NSIP).

METHODS

Specimens were obtained by open or video-assisted thoracoscopic lung biopsy from patients with UIP (n = 5) and NSIP (n = 8). Control specimens were obtained by surgical lobectomy from patients with primary lung cancer (n = 5). The distribution of these cytokines in lung tissues was observed by semi-quantitative method using immunohistochemical staining.

RESULTS

TGF-beta(1), IL-8 and b-FGF were localized in alveolar epithelial cells, alveolar macrophages, and the bronchial epithelium. Overall intensity of TGF-beta(1), IL-8 and b-FGF expression in UIP was stronger in comparison with NSIP. IL-13 was distributed in alveolar epithelial cells, alveolar macrophages and interstitial mononuclear cells. Its expression in UIP was similar to that in NSIP. IFN-gamma was expressed mainly in interstitial mononuclear cells. Its expression in NSIP was stronger than that in UIP. The ratio of IL-13 to IFN-gamma in UIP (2.18 +/- 0.76) was significantly higher than that in NSIP (0.95 +/- 0.28) or that in the control (0.91 +/- 0.16) (P < 0.05, UIP versus NSIP or control), whereas the ratio of IL-13 to IFN-gamma in NSIP was similar to that in the control. In normal lungs, only alveolar macrophages expressed these cytokines.

CONCLUSION

The different expression of TGF-beta(1), IL-8 and b-FGF in UIP and NSIP and the balance of IL-13/IFN-gamma may be involved in the different pathogenesis in these two diseases.

Authors+Show Affiliations

Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12899768

Citation

Gu, Li, et al. "[Different Cytokine Profiles in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 26, no. 6, 2003, pp. 350-3.
Gu L, Xu WB, Liu HR, et al. [Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(6):350-3.
Gu, L., Xu, W. B., Liu, H. R., Guo, Z. J., Xu, X. X., & Zhu, Y. J. (2003). [Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 26(6), 350-3.
Gu L, et al. [Different Cytokine Profiles in Usual Interstitial Pneumonia and Nonspecific Interstitial Pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(6):350-3. PubMed PMID: 12899768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia]. AU - Gu,Li, AU - Xu,Wen-bing, AU - Liu,Hong-rui, AU - Guo,Zi-jian, AU - Xu,Xing-xiang, AU - Zhu,Yuan-jue, PY - 2003/8/6/pubmed PY - 2003/11/8/medline PY - 2003/8/6/entrez SP - 350 EP - 3 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 26 IS - 6 N2 - OBJECTIVE: To study the distribution, the expression and the significance of TGF-beta(1), b-FGF, IL-8, IL-13 and IFN-gamma in different lung tissue compartments in usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) and nonspecific interstitial pneumonia (NSIP). METHODS: Specimens were obtained by open or video-assisted thoracoscopic lung biopsy from patients with UIP (n = 5) and NSIP (n = 8). Control specimens were obtained by surgical lobectomy from patients with primary lung cancer (n = 5). The distribution of these cytokines in lung tissues was observed by semi-quantitative method using immunohistochemical staining. RESULTS: TGF-beta(1), IL-8 and b-FGF were localized in alveolar epithelial cells, alveolar macrophages, and the bronchial epithelium. Overall intensity of TGF-beta(1), IL-8 and b-FGF expression in UIP was stronger in comparison with NSIP. IL-13 was distributed in alveolar epithelial cells, alveolar macrophages and interstitial mononuclear cells. Its expression in UIP was similar to that in NSIP. IFN-gamma was expressed mainly in interstitial mononuclear cells. Its expression in NSIP was stronger than that in UIP. The ratio of IL-13 to IFN-gamma in UIP (2.18 +/- 0.76) was significantly higher than that in NSIP (0.95 +/- 0.28) or that in the control (0.91 +/- 0.16) (P < 0.05, UIP versus NSIP or control), whereas the ratio of IL-13 to IFN-gamma in NSIP was similar to that in the control. In normal lungs, only alveolar macrophages expressed these cytokines. CONCLUSION: The different expression of TGF-beta(1), IL-8 and b-FGF in UIP and NSIP and the balance of IL-13/IFN-gamma may be involved in the different pathogenesis in these two diseases. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/12899768/[Different_cytokine_profiles_in_usual_interstitial_pneumonia_and_nonspecific_interstitial_pneumonia]_ L2 - http://www.diseaseinfosearch.org/result/7327 DB - PRIME DP - Unbound Medicine ER -