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Separation of aminoalkanephosphonic acid enantiomers by indirect UV detection capillary electrophoresis with application of cyclodextrins.
Electrophoresis. 2003 Aug; 24(15):2693-7.E

Abstract

Indirect UV detection capillary electrophoresis (CE) was used for the separation of aminoalkanephosphonic acid (AP) enantiomers by applying commercially available cyclodextrins as chiral discriminators. The results show that the separation of the enantiomers depends on pH of the background electrolyte, the molar ratio of cyclodextrin to aminophosphonic acid, and on the type of the applied chiral selector. Optimization of process conditions allowed enantiomeric baseline separation or partial separation of 12 out of 14 alpha-aminophosphonic acids studied. This type of CE might therefore be successfully used for routine determination of enantiomeric purity of aminophosphonic acids.

Authors+Show Affiliations

Rudzińska E
Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology, Wroclaw, Poland.
Wieczorek P
No affiliation info available
Kafarski P
No affiliation info available

MeSH

AminesCyclodextrinsElectrophoresis, CapillaryHydrogen-Ion ConcentrationOrganophosphonatesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12900884

Citation

Rudzińska, Ewa, et al. "Separation of Aminoalkanephosphonic Acid Enantiomers By Indirect UV Detection Capillary Electrophoresis With Application of Cyclodextrins." Electrophoresis, vol. 24, no. 15, 2003, pp. 2693-7.
Rudzińska E, Wieczorek P, Kafarski P. Separation of aminoalkanephosphonic acid enantiomers by indirect UV detection capillary electrophoresis with application of cyclodextrins. Electrophoresis. 2003;24(15):2693-7.
Rudzińska, E., Wieczorek, P., & Kafarski, P. (2003). Separation of aminoalkanephosphonic acid enantiomers by indirect UV detection capillary electrophoresis with application of cyclodextrins. Electrophoresis, 24(15), 2693-7.
Rudzińska E, Wieczorek P, Kafarski P. Separation of Aminoalkanephosphonic Acid Enantiomers By Indirect UV Detection Capillary Electrophoresis With Application of Cyclodextrins. Electrophoresis. 2003;24(15):2693-7. PubMed PMID: 12900884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Separation of aminoalkanephosphonic acid enantiomers by indirect UV detection capillary electrophoresis with application of cyclodextrins. AU - Rudzińska,Ewa, AU - Wieczorek,Piotr, AU - Kafarski,Paweł, PY - 2003/8/6/pubmed PY - 2004/6/18/medline PY - 2003/8/6/entrez SP - 2693 EP - 7 JF - Electrophoresis JO - Electrophoresis VL - 24 IS - 15 N2 - Indirect UV detection capillary electrophoresis (CE) was used for the separation of aminoalkanephosphonic acid (AP) enantiomers by applying commercially available cyclodextrins as chiral discriminators. The results show that the separation of the enantiomers depends on pH of the background electrolyte, the molar ratio of cyclodextrin to aminophosphonic acid, and on the type of the applied chiral selector. Optimization of process conditions allowed enantiomeric baseline separation or partial separation of 12 out of 14 alpha-aminophosphonic acids studied. This type of CE might therefore be successfully used for routine determination of enantiomeric purity of aminophosphonic acids. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/12900884/Separation_of_aminoalkanephosphonic_acid_enantiomers_by_indirect_UV_detection_capillary_electrophoresis_with_application_of_cyclodextrins_ DB - PRIME DP - Unbound Medicine ER -