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Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus).
Environ Toxicol. 2003 Aug; 18(4):260-7.ET

Abstract

In Oreochromis niloticus that had been exposed for 3 months to sublethal concentrations (5 and 15 ppm) of the commercial glyphosate herbicide (C(3)H(8)NO(5)P) Roundup, the organs exhibited varying degrees of histopathological change. In the gills filament cell proliferation, lamellar cell hyperplasia, lamellar fusion, epithelial lifting, and aneurysm were observed. In the liver there were vacuolation of hepatocytes and nuclear pyknosis. Kidney lesions consisted of dilation of Bowman's space and accumulation of hyaline droplets in the tubular epithelial cells. The structural damages could be correlated to the significant increase (p </= 0.05) in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities in the second and third months of exposure. The results indicated that long-term exposure to glyphosate at sublethal concentrations had adverse effects on the histopathological and biochemical alterations of the fish.

Authors+Show Affiliations

Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12900945

Citation

Jiraungkoorskul, W, et al. "Biochemical and Histopathological Effects of Glyphosate Herbicide On Nile Tilapia (Oreochromis Niloticus)." Environmental Toxicology, vol. 18, no. 4, 2003, pp. 260-7.
Jiraungkoorskul W, Upatham ES, Kruatrachue M, et al. Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus). Environ Toxicol. 2003;18(4):260-7.
Jiraungkoorskul, W., Upatham, E. S., Kruatrachue, M., Sahaphong, S., Vichasri-Grams, S., & Pokethitiyook, P. (2003). Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus). Environmental Toxicology, 18(4), 260-7.
Jiraungkoorskul W, et al. Biochemical and Histopathological Effects of Glyphosate Herbicide On Nile Tilapia (Oreochromis Niloticus). Environ Toxicol. 2003;18(4):260-7. PubMed PMID: 12900945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus). AU - Jiraungkoorskul,W, AU - Upatham,E S, AU - Kruatrachue,M, AU - Sahaphong,S, AU - Vichasri-Grams,S, AU - Pokethitiyook,P, PY - 2003/8/6/pubmed PY - 2003/12/9/medline PY - 2003/8/6/entrez SP - 260 EP - 7 JF - Environmental toxicology JO - Environ Toxicol VL - 18 IS - 4 N2 - In Oreochromis niloticus that had been exposed for 3 months to sublethal concentrations (5 and 15 ppm) of the commercial glyphosate herbicide (C(3)H(8)NO(5)P) Roundup, the organs exhibited varying degrees of histopathological change. In the gills filament cell proliferation, lamellar cell hyperplasia, lamellar fusion, epithelial lifting, and aneurysm were observed. In the liver there were vacuolation of hepatocytes and nuclear pyknosis. Kidney lesions consisted of dilation of Bowman's space and accumulation of hyaline droplets in the tubular epithelial cells. The structural damages could be correlated to the significant increase (p </= 0.05) in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities in the second and third months of exposure. The results indicated that long-term exposure to glyphosate at sublethal concentrations had adverse effects on the histopathological and biochemical alterations of the fish. SN - 1520-4081 UR - https://www.unboundmedicine.com/medline/citation/12900945/Biochemical_and_histopathological_effects_of_glyphosate_herbicide_on_Nile_tilapia__Oreochromis_niloticus__ L2 - https://doi.org/10.1002/tox.10123 DB - PRIME DP - Unbound Medicine ER -