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Erythrocyte adhesion in sickle cell disease.
Curr Hematol Rep 2003; 2(2):102-8CH

Abstract

The vaso-occlusive process in patients with sickle cell disease is complex and is likely to involve interactions between hemoglobin S red blood cells (SS RBCs) and vascular endothelium, as well as between SS RBCs and leukocytes. Vaso-occlusive events lead to recurrent pain and a wide spectrum of end-organ damage, including pulmonary hypertension and renal failure. However, the triggers inducing adhesion and vaso-occlusion are only now being elucidated. Investigators have characterized the ability of a number of RBC surface structures to adhere to both endothelial cells and components of the subendothelial extracellular matrix. In addition, evidence is accumulating to suggest that SS RBC adhesion receptors undergo activation under physiologic conditions. An understanding of these mechanisms at the molecular level should ultimately allow development of new preventive and treatment strategies to abrogate vaso-occlusive events.

Authors+Show Affiliations

DUMC Box 2615, 333 Medical Research Building, Duke University Medical Center, Durham, NC 27710, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12901140

Citation

Parise, Leslie V., and Marilyn J. Telen. "Erythrocyte Adhesion in Sickle Cell Disease." Current Hematology Reports, vol. 2, no. 2, 2003, pp. 102-8.
Parise LV, Telen MJ. Erythrocyte adhesion in sickle cell disease. Curr Hematol Rep. 2003;2(2):102-8.
Parise, L. V., & Telen, M. J. (2003). Erythrocyte adhesion in sickle cell disease. Current Hematology Reports, 2(2), pp. 102-8.
Parise LV, Telen MJ. Erythrocyte Adhesion in Sickle Cell Disease. Curr Hematol Rep. 2003;2(2):102-8. PubMed PMID: 12901140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte adhesion in sickle cell disease. AU - Parise,Leslie V, AU - Telen,Marilyn J, PY - 2003/8/7/pubmed PY - 2003/10/16/medline PY - 2003/8/7/entrez SP - 102 EP - 8 JF - Current hematology reports JO - Curr. Hematol. Rep. VL - 2 IS - 2 N2 - The vaso-occlusive process in patients with sickle cell disease is complex and is likely to involve interactions between hemoglobin S red blood cells (SS RBCs) and vascular endothelium, as well as between SS RBCs and leukocytes. Vaso-occlusive events lead to recurrent pain and a wide spectrum of end-organ damage, including pulmonary hypertension and renal failure. However, the triggers inducing adhesion and vaso-occlusion are only now being elucidated. Investigators have characterized the ability of a number of RBC surface structures to adhere to both endothelial cells and components of the subendothelial extracellular matrix. In addition, evidence is accumulating to suggest that SS RBC adhesion receptors undergo activation under physiologic conditions. An understanding of these mechanisms at the molecular level should ultimately allow development of new preventive and treatment strategies to abrogate vaso-occlusive events. SN - 1540-3408 UR - https://www.unboundmedicine.com/medline/citation/12901140/Erythrocyte_adhesion_in_sickle_cell_disease_ L2 - http://www.diseaseinfosearch.org/result/6589 DB - PRIME DP - Unbound Medicine ER -