Tags

Type your tag names separated by a space and hit enter

Comparison of the effects of losartan, enalapril and their combination in the prevention of left ventricular remodeling after acute myocardial infarction in the rat.
Chin Med Sci J. 2002 Dec; 17(4):236-41.CM

Abstract

OBJECTIVES

To compare the effects of losartan, enalapril and their combination in the prevention of left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in the rat.

METHODS

AMI model was induced in female SD rats by ligating left coronary artery. Forty-eight hours after the procedure, 83 surviving rats were randomized into one of the following 4 groups : 1) AMI control group (n = 19), 2) losartan group (n = 22, 3 mg x kg(-1) x d(-1)), 3) enalapril group (n = 20, 1 mg x kg(-1) x d(-1)), 4) losartan-enalapril combinative group (n = 22, 3 and 1 mg x kg(-1) x d(-1) respectively). 5) Sham-operated group (n = 10) and 6) normal rats group (n = 10) were selected randomly to serve as non-infarction controls. Losartan and enalapril were delivered by direct gastric gavage. After 4 weeks of medical therapy, hemodynamic studies were performed in each group, then the rat hearts were fixed with 10% formalin and pathologic analysis on them was performed. Complete experimental data was obtained in 56 rats, comprising 1) AMI controls (n = 11), 2) losartan group (n = 10), 3) enalapril group (n = 10), 4) the combination of losartan and enalapril group (n = 11), 5) sham-operated group (n = 6) and 6) normal controls (n = 8).

RESULTS

There were no significant differences among the 4 AMI groups in MI size (41.7% to approximately 43.4%, all P > 0.05). Compared with sham group, the left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), long and short axis length (L and D), as well as LV absolute and relative weight (LVAW and LVRW) in AMI group were all significantly increased (P < 0.05 to approximately 0.001); whereas the maximum left ventricular pressure rising and dropping rates (+/- dp/dt) and their corrected values by LV systolic pressure (+/- dp/dt/LVSP) were significantly reduced (all P < 0.001), indicating LVRM occurred and LV systolic and diastolic function impaired after AMI. Compared with AMI group, LVEDP, LVV, LVAW and LVRW were all significantly decreased (P < 0.05 to approximately 0.001); while +/- dp/dt/LVSP were significantly enhanced in all 3 treatment groups (P < 0.05 to approximately 0.001) except -dp/dt/LVSP in losartan group (P > 0.05). There were no significant differences in the above indices among the 3 treatment groups (all P > 0.05).

CONCLUSION

Both losartan and enalapril can prevent from LVRM after AMI in the rat and improve LV function with equivalent effects. There seems no additive effect when the 2 drugs are used in combination.

Authors+Show Affiliations

Division of Coronary Heart Disease, Cardiovascular Institute and Fu Wai Hospital, CAMS & PUMC, Beijing 100037.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12901512

Citation

Yuejin, Yang, et al. "Comparison of the Effects of Losartan, Enalapril and Their Combination in the Prevention of Left Ventricular Remodeling After Acute Myocardial Infarction in the Rat." Chinese Medical Sciences Journal = Chung-kuo I Hsueh K'o Hsueh Tsa Chih, vol. 17, no. 4, 2002, pp. 236-41.
Yuejin Y, Pei Z, Yingmao R, et al. Comparison of the effects of losartan, enalapril and their combination in the prevention of left ventricular remodeling after acute myocardial infarction in the rat. Chin Med Sci J. 2002;17(4):236-41.
Yuejin, Y., Pei, Z., Yingmao, R., Laifeng, S., Xinglin, X., Yongli, L., Yanwen, Z., Yi, T., Yishu, X., & Zaijia, C. (2002). Comparison of the effects of losartan, enalapril and their combination in the prevention of left ventricular remodeling after acute myocardial infarction in the rat. Chinese Medical Sciences Journal = Chung-kuo I Hsueh K'o Hsueh Tsa Chih, 17(4), 236-41.
Yuejin Y, et al. Comparison of the Effects of Losartan, Enalapril and Their Combination in the Prevention of Left Ventricular Remodeling After Acute Myocardial Infarction in the Rat. Chin Med Sci J. 2002;17(4):236-41. PubMed PMID: 12901512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effects of losartan, enalapril and their combination in the prevention of left ventricular remodeling after acute myocardial infarction in the rat. AU - Yuejin,Yang, AU - Pei,Zhang, AU - Yingmao,Ruan, AU - Laifeng,Song, AU - Xinglin,Xu, AU - Yongli,Li, AU - Yanwen,Zhou, AU - Yi,Tian, AU - Yishu,Xu, AU - Zaijia,Chen, PY - 2003/8/7/pubmed PY - 2004/4/21/medline PY - 2003/8/7/entrez SP - 236 EP - 41 JF - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih JO - Chin Med Sci J VL - 17 IS - 4 N2 - OBJECTIVES: To compare the effects of losartan, enalapril and their combination in the prevention of left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in the rat. METHODS: AMI model was induced in female SD rats by ligating left coronary artery. Forty-eight hours after the procedure, 83 surviving rats were randomized into one of the following 4 groups : 1) AMI control group (n = 19), 2) losartan group (n = 22, 3 mg x kg(-1) x d(-1)), 3) enalapril group (n = 20, 1 mg x kg(-1) x d(-1)), 4) losartan-enalapril combinative group (n = 22, 3 and 1 mg x kg(-1) x d(-1) respectively). 5) Sham-operated group (n = 10) and 6) normal rats group (n = 10) were selected randomly to serve as non-infarction controls. Losartan and enalapril were delivered by direct gastric gavage. After 4 weeks of medical therapy, hemodynamic studies were performed in each group, then the rat hearts were fixed with 10% formalin and pathologic analysis on them was performed. Complete experimental data was obtained in 56 rats, comprising 1) AMI controls (n = 11), 2) losartan group (n = 10), 3) enalapril group (n = 10), 4) the combination of losartan and enalapril group (n = 11), 5) sham-operated group (n = 6) and 6) normal controls (n = 8). RESULTS: There were no significant differences among the 4 AMI groups in MI size (41.7% to approximately 43.4%, all P > 0.05). Compared with sham group, the left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), long and short axis length (L and D), as well as LV absolute and relative weight (LVAW and LVRW) in AMI group were all significantly increased (P < 0.05 to approximately 0.001); whereas the maximum left ventricular pressure rising and dropping rates (+/- dp/dt) and their corrected values by LV systolic pressure (+/- dp/dt/LVSP) were significantly reduced (all P < 0.001), indicating LVRM occurred and LV systolic and diastolic function impaired after AMI. Compared with AMI group, LVEDP, LVV, LVAW and LVRW were all significantly decreased (P < 0.05 to approximately 0.001); while +/- dp/dt/LVSP were significantly enhanced in all 3 treatment groups (P < 0.05 to approximately 0.001) except -dp/dt/LVSP in losartan group (P > 0.05). There were no significant differences in the above indices among the 3 treatment groups (all P > 0.05). CONCLUSION: Both losartan and enalapril can prevent from LVRM after AMI in the rat and improve LV function with equivalent effects. There seems no additive effect when the 2 drugs are used in combination. SN - 1001-9294 UR - https://www.unboundmedicine.com/medline/citation/12901512/Comparison_of_the_effects_of_losartan_enalapril_and_their_combination_in_the_prevention_of_left_ventricular_remodeling_after_acute_myocardial_infarction_in_the_rat_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -