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Phytoestrogen intake and endometrial cancer risk.
J Natl Cancer Inst 2003; 95(15):1158-64JNCI

Abstract

BACKGROUND

The development of endometrial cancer is largely related to prolonged exposure to unopposed estrogens. Phytoestrogens (i.e., weak estrogens found in plant foods) may have antiestrogenic effects. We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer.

METHODS

In a case-control study from the greater San Francisco Bay Area, we collected dietary information from 500 African American, Latina, and white women aged 35-79 years who were diagnosed with endometrial cancer between 1996 and 1999 and from 470 age- and ethnicity-matched control women identified through random-digit dialing. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

Isoflavone (OR = 0.59, 95% CI = 0.37 to 0.93 for the highest versus lowest quartile of exposure) and lignan (OR = 0.68, 95% CI = 0.44 to 1.1) consumptions were inversely related to the risk of endometrial cancer. These associations were slightly stronger in postmenopausal women (OR = 0.44, 95% CI = 0.26 to 0.77 and OR = 0.57, 95% CI = 0.34 to 0.97 for isoflavones and lignans, respectively). Obese postmenopausal women consuming relatively low amounts of phytoestrogens had the highest risk of endometrial cancer (OR = 6.9, 95% CI = 3.3 to 14.5 compared with non-obese postmenopausal women consuming relatively high amounts of isoflavones); however, the interaction between obesity and phytoestrogen intake was not statistically significant.

CONCLUSION

Some phytoestrogenic compounds, at the levels consumed in the typical American-style diet, are associated with reduced risk of endometrial cancer.

Authors+Show Affiliations

Northern California Cancer Center, Union City, CA 94587, USA. phornros@nccc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12902445

Citation

Horn-Ross, Pamela L., et al. "Phytoestrogen Intake and Endometrial Cancer Risk." Journal of the National Cancer Institute, vol. 95, no. 15, 2003, pp. 1158-64.
Horn-Ross PL, John EM, Canchola AJ, et al. Phytoestrogen intake and endometrial cancer risk. J Natl Cancer Inst. 2003;95(15):1158-64.
Horn-Ross, P. L., John, E. M., Canchola, A. J., Stewart, S. L., & Lee, M. M. (2003). Phytoestrogen intake and endometrial cancer risk. Journal of the National Cancer Institute, 95(15), pp. 1158-64.
Horn-Ross PL, et al. Phytoestrogen Intake and Endometrial Cancer Risk. J Natl Cancer Inst. 2003 Aug 6;95(15):1158-64. PubMed PMID: 12902445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytoestrogen intake and endometrial cancer risk. AU - Horn-Ross,Pamela L, AU - John,Esther M, AU - Canchola,Alison J, AU - Stewart,Susan L, AU - Lee,Marion M, PY - 2003/8/7/pubmed PY - 2003/8/14/medline PY - 2003/8/7/entrez SP - 1158 EP - 64 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 95 IS - 15 N2 - BACKGROUND: The development of endometrial cancer is largely related to prolonged exposure to unopposed estrogens. Phytoestrogens (i.e., weak estrogens found in plant foods) may have antiestrogenic effects. We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer. METHODS: In a case-control study from the greater San Francisco Bay Area, we collected dietary information from 500 African American, Latina, and white women aged 35-79 years who were diagnosed with endometrial cancer between 1996 and 1999 and from 470 age- and ethnicity-matched control women identified through random-digit dialing. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Isoflavone (OR = 0.59, 95% CI = 0.37 to 0.93 for the highest versus lowest quartile of exposure) and lignan (OR = 0.68, 95% CI = 0.44 to 1.1) consumptions were inversely related to the risk of endometrial cancer. These associations were slightly stronger in postmenopausal women (OR = 0.44, 95% CI = 0.26 to 0.77 and OR = 0.57, 95% CI = 0.34 to 0.97 for isoflavones and lignans, respectively). Obese postmenopausal women consuming relatively low amounts of phytoestrogens had the highest risk of endometrial cancer (OR = 6.9, 95% CI = 3.3 to 14.5 compared with non-obese postmenopausal women consuming relatively high amounts of isoflavones); however, the interaction between obesity and phytoestrogen intake was not statistically significant. CONCLUSION: Some phytoestrogenic compounds, at the levels consumed in the typical American-style diet, are associated with reduced risk of endometrial cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/12902445/Phytoestrogen_intake_and_endometrial_cancer_risk_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djg015 DB - PRIME DP - Unbound Medicine ER -