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A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease.
Neuroepidemiology. 2003 Sep-Oct; 22(5):297-304.N

Abstract

OBJECTIVE

To investigate the association between cigarette smoking, alcohol drinking, coffee consumption and Parkinson's disease (PD).

METHODS

We selected subjects affected by idiopathic PD, with a Mini-Mental State Examination of > or =24, and controls matched 1 to 1 with cases by age (+/- 2 years) and sex. Controls were randomly selected from the resident list of the same municipality of residence of the cases. We assessed cigarette smoking, alcohol drinking, and coffee consumption preceding the onset of PD or the corresponding time for controls using a structured questionnaire, which also evaluated the duration and dose of exposure. Using conditional logistic regression analysis, we calculated adjusted OR and 95% CI.

RESULTS

We interviewed 150 PD patients and 150 matched controls. Cigarette smoking (ever vs. never smokers OR = 0.66, 95% CI = 0.41-1.05, p = 0.08) did not show a statistically significant association with PD. We observed an inverse association between alcohol drinking (ever vs. never OR = 0.61, 95% CI = 0.39-0.97, p = 0.037) and coffee consumption (ever vs. never OR = 0.16, 95% CI 0.05-0.46, p = 0.0001) and PD. These associations remained significant after adjustment for other covariates: OR for ever vs. never alcohol consumption was 0.62 (95% CI = 0.43-0.89, p = 0.009) and that for coffee drinking 0.19 (95% CI = 0.07-0.52, p = 0.001). Heavy coffee consumption confirmed the inverse association between coffee and PD (more than 81 cup/year vs. none: OR = 0.20, 95% CI = 0.08-0.47, p < or = 0.0001).

CONCLUSIONS

Consistent with previous studies, our results suggest an inverse association between coffee drinking, alcohol consumption and PD. The multiple inverse association observed may indicate a complex interaction between genetic and environmental factors.

Authors+Show Affiliations

Department of Neuropsychiatry, University of Palermo, Via Gaetano La Loggia I, IT-90129 Palermo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12902625

Citation

Ragonese, P, et al. "A Case-control Study On Cigarette, Alcohol, and Coffee Consumption Preceding Parkinson's Disease." Neuroepidemiology, vol. 22, no. 5, 2003, pp. 297-304.
Ragonese P, Salemi G, Morgante L, et al. A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. Neuroepidemiology. 2003;22(5):297-304.
Ragonese, P., Salemi, G., Morgante, L., Aridon, P., Epifanio, A., Buffa, D., Scoppa, F., & Savettieri, G. (2003). A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. Neuroepidemiology, 22(5), 297-304.
Ragonese P, et al. A Case-control Study On Cigarette, Alcohol, and Coffee Consumption Preceding Parkinson's Disease. Neuroepidemiology. 2003 Sep-Oct;22(5):297-304. PubMed PMID: 12902625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. AU - Ragonese,P, AU - Salemi,G, AU - Morgante,L, AU - Aridon,P, AU - Epifanio,A, AU - Buffa,D, AU - Scoppa,F, AU - Savettieri,G, PY - 2003/8/7/pubmed PY - 2003/12/13/medline PY - 2003/8/7/entrez SP - 297 EP - 304 JF - Neuroepidemiology JO - Neuroepidemiology VL - 22 IS - 5 N2 - OBJECTIVE: To investigate the association between cigarette smoking, alcohol drinking, coffee consumption and Parkinson's disease (PD). METHODS: We selected subjects affected by idiopathic PD, with a Mini-Mental State Examination of > or =24, and controls matched 1 to 1 with cases by age (+/- 2 years) and sex. Controls were randomly selected from the resident list of the same municipality of residence of the cases. We assessed cigarette smoking, alcohol drinking, and coffee consumption preceding the onset of PD or the corresponding time for controls using a structured questionnaire, which also evaluated the duration and dose of exposure. Using conditional logistic regression analysis, we calculated adjusted OR and 95% CI. RESULTS: We interviewed 150 PD patients and 150 matched controls. Cigarette smoking (ever vs. never smokers OR = 0.66, 95% CI = 0.41-1.05, p = 0.08) did not show a statistically significant association with PD. We observed an inverse association between alcohol drinking (ever vs. never OR = 0.61, 95% CI = 0.39-0.97, p = 0.037) and coffee consumption (ever vs. never OR = 0.16, 95% CI 0.05-0.46, p = 0.0001) and PD. These associations remained significant after adjustment for other covariates: OR for ever vs. never alcohol consumption was 0.62 (95% CI = 0.43-0.89, p = 0.009) and that for coffee drinking 0.19 (95% CI = 0.07-0.52, p = 0.001). Heavy coffee consumption confirmed the inverse association between coffee and PD (more than 81 cup/year vs. none: OR = 0.20, 95% CI = 0.08-0.47, p < or = 0.0001). CONCLUSIONS: Consistent with previous studies, our results suggest an inverse association between coffee drinking, alcohol consumption and PD. The multiple inverse association observed may indicate a complex interaction between genetic and environmental factors. SN - 0251-5350 UR - https://www.unboundmedicine.com/medline/citation/12902625/A_case_control_study_on_cigarette_alcohol_and_coffee_consumption_preceding_Parkinson's_disease_ L2 - https://www.karger.com?DOI=10.1159/000071193 DB - PRIME DP - Unbound Medicine ER -