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Non-NMDA receptors within caudal ventrolateral medulla are involved in transmission of baroreflex of rats.
Acta Pharmacol Sin. 2003 Aug; 24(8):783-9.AP

Abstract

AIM

To investigate the role of non N-methyl-D-aspartate acid (non-NMDA) receptors within the caudal ventrolateral medulla (CVLM) in mediating the baroreflex.

METHODS

In urethane-anesthetized, paralyzed, and artificially ventilated rats, the effects of 6-cyano-7-nitroquinoxaline-2,3-dinoe (CNQX, a selective non-NMDA receptors antagonist) locally injected into the CVLM on the depressor responses evoked by aortic nerve stimulation and the barosensitivity of the rostral ventrolateral medulla (RVLM) barosensitive neurons were observed.

RESULTS

Bilateral microinjection of CNQX (200 pmol in 100 nL for each side) into the CVLM significantly (P<0.01) increased the blood pressure (BP) and heart rate, and markedly (P<0.01) attenuated the depressor response to the aortic nerve stimulation. CNQX (200 pmol in 100 nL) unilaterally injected into the CVLM significantly (P<0.01) increased the firing rate of the ipsilateral RVLM barosensitive neurons and reduced the inhibitory responses of neurons evoked by stimulation of aortic nerve and elevation of BP, and partially inhibited the neuronal cardiac cycle-related rhythm.

CONCLUSION

The CVLM played an important role in maintaining the tonic excitatory cardiovascular activities and transmitting the baroreceptor information via activation of non-NMDA receptors.

Authors+Show Affiliations

Department of Physiology, Second Military Medical University, Shanghai 200433, China. wangwz@smmu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12904278

Citation

Wang, Wei-Zhong, et al. "Non-NMDA Receptors Within Caudal Ventrolateral Medulla Are Involved in Transmission of Baroreflex of Rats." Acta Pharmacologica Sinica, vol. 24, no. 8, 2003, pp. 783-9.
Wang WZ, Yuan WJ, Pan YX, et al. Non-NMDA receptors within caudal ventrolateral medulla are involved in transmission of baroreflex of rats. Acta Pharmacol Sin. 2003;24(8):783-9.
Wang, W. Z., Yuan, W. J., Pan, Y. X., Bai, J., Liao, M. Y., & Tang, C. S. (2003). Non-NMDA receptors within caudal ventrolateral medulla are involved in transmission of baroreflex of rats. Acta Pharmacologica Sinica, 24(8), 783-9.
Wang WZ, et al. Non-NMDA Receptors Within Caudal Ventrolateral Medulla Are Involved in Transmission of Baroreflex of Rats. Acta Pharmacol Sin. 2003;24(8):783-9. PubMed PMID: 12904278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-NMDA receptors within caudal ventrolateral medulla are involved in transmission of baroreflex of rats. AU - Wang,Wei-Zhong, AU - Yuan,Wen-Jun, AU - Pan,Yan-Xia, AU - Bai,Jie, AU - Liao,Mao-Yao, AU - Tang,Chao-Shu, PY - 2003/8/9/pubmed PY - 2004/3/17/medline PY - 2003/8/9/entrez SP - 783 EP - 9 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 24 IS - 8 N2 - AIM: To investigate the role of non N-methyl-D-aspartate acid (non-NMDA) receptors within the caudal ventrolateral medulla (CVLM) in mediating the baroreflex. METHODS: In urethane-anesthetized, paralyzed, and artificially ventilated rats, the effects of 6-cyano-7-nitroquinoxaline-2,3-dinoe (CNQX, a selective non-NMDA receptors antagonist) locally injected into the CVLM on the depressor responses evoked by aortic nerve stimulation and the barosensitivity of the rostral ventrolateral medulla (RVLM) barosensitive neurons were observed. RESULTS: Bilateral microinjection of CNQX (200 pmol in 100 nL for each side) into the CVLM significantly (P<0.01) increased the blood pressure (BP) and heart rate, and markedly (P<0.01) attenuated the depressor response to the aortic nerve stimulation. CNQX (200 pmol in 100 nL) unilaterally injected into the CVLM significantly (P<0.01) increased the firing rate of the ipsilateral RVLM barosensitive neurons and reduced the inhibitory responses of neurons evoked by stimulation of aortic nerve and elevation of BP, and partially inhibited the neuronal cardiac cycle-related rhythm. CONCLUSION: The CVLM played an important role in maintaining the tonic excitatory cardiovascular activities and transmitting the baroreceptor information via activation of non-NMDA receptors. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/12904278/Non_NMDA_receptors_within_caudal_ventrolateral_medulla_are_involved_in_transmission_of_baroreflex_of_rats_ L2 - http://www.chinaphar.com/1671-4083/24/783.pdf DB - PRIME DP - Unbound Medicine ER -