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Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes.
Am J Respir Crit Care Med. 2003 Nov 15; 168(10):1181-9.AJ

Abstract

In elite athletes, exercise-induced bronchoconstriction (EIB) may respond to dietary modification, thereby reducing the need for pharmacologic treatment. Ten elite athletes with EIB and 10 elite athletes without EIB (control subjects) participated in a randomized, double-blind crossover study. Subjects entered the study on their normal diet, and then received either fish oil capsules containing 3.2 g eicosapentaenoic acid and 2.2 g docohexaenoic acid (n-3 polyunsaturated fatty acid [PUFA] diet; n = 5) or placebo capsules containing olive oil (placebo diet; n = 5) taken daily for 3 weeks. Diet had no effect on preexercise pulmonary function in either group or on postexercise pulmonary function in control subjects. However, in subjects with EIB, the n-3 PUFA diet improved postexercise pulmonary function compared with the normal and placebo diets. FEV1 decreased by 3 +/- 2% on n-3 PUFA diet, 14.5 +/- 5% on placebo diet, and 17.3 +/- 6% on normal diet at 15 minutes postexercise. Leukotriene (LT)E4, 9alpha, 11beta-prostaglandin F2, LTB4, tumor necrosis factor-alpha, and interleukin-1beta, all significantly decreased on the n-3 PUFA diet compared with normal and placebo diets and after the exercise challenge. These data suggest that dietary fish oil supplementation has a markedly protective effect in suppressing EIB in elite athletes, and this may be attributed to their antiinflammatory properties.

Authors+Show Affiliations

Department of Kinesiology, Indiana University, 1025 East 7th Street, HPER 112, Bloomington, IN 47401, USA. tmickleb@indiana.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12904324

Citation

Mickleborough, Timothy D., et al. "Fish Oil Supplementation Reduces Severity of Exercise-induced Bronchoconstriction in Elite Athletes." American Journal of Respiratory and Critical Care Medicine, vol. 168, no. 10, 2003, pp. 1181-9.
Mickleborough TD, Murray RL, Ionescu AA, et al. Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med. 2003;168(10):1181-9.
Mickleborough, T. D., Murray, R. L., Ionescu, A. A., & Lindley, M. R. (2003). Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. American Journal of Respiratory and Critical Care Medicine, 168(10), 1181-9.
Mickleborough TD, et al. Fish Oil Supplementation Reduces Severity of Exercise-induced Bronchoconstriction in Elite Athletes. Am J Respir Crit Care Med. 2003 Nov 15;168(10):1181-9. PubMed PMID: 12904324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. AU - Mickleborough,Timothy D, AU - Murray,Rachael L, AU - Ionescu,Alina A, AU - Lindley,Martin R, Y1 - 2003/08/06/ PY - 2003/8/9/pubmed PY - 2003/12/24/medline PY - 2003/8/9/entrez SP - 1181 EP - 9 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 168 IS - 10 N2 - In elite athletes, exercise-induced bronchoconstriction (EIB) may respond to dietary modification, thereby reducing the need for pharmacologic treatment. Ten elite athletes with EIB and 10 elite athletes without EIB (control subjects) participated in a randomized, double-blind crossover study. Subjects entered the study on their normal diet, and then received either fish oil capsules containing 3.2 g eicosapentaenoic acid and 2.2 g docohexaenoic acid (n-3 polyunsaturated fatty acid [PUFA] diet; n = 5) or placebo capsules containing olive oil (placebo diet; n = 5) taken daily for 3 weeks. Diet had no effect on preexercise pulmonary function in either group or on postexercise pulmonary function in control subjects. However, in subjects with EIB, the n-3 PUFA diet improved postexercise pulmonary function compared with the normal and placebo diets. FEV1 decreased by 3 +/- 2% on n-3 PUFA diet, 14.5 +/- 5% on placebo diet, and 17.3 +/- 6% on normal diet at 15 minutes postexercise. Leukotriene (LT)E4, 9alpha, 11beta-prostaglandin F2, LTB4, tumor necrosis factor-alpha, and interleukin-1beta, all significantly decreased on the n-3 PUFA diet compared with normal and placebo diets and after the exercise challenge. These data suggest that dietary fish oil supplementation has a markedly protective effect in suppressing EIB in elite athletes, and this may be attributed to their antiinflammatory properties. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/12904324/Fish_oil_supplementation_reduces_severity_of_exercise_induced_bronchoconstriction_in_elite_athletes_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200303-373OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -