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Impact of intravenous antibiotic therapy on total daily energy expenditure and physical activity in cystic fibrosis children with Pseudomonas aeruginosa pulmonary exacerbation.
Pediatr Res 2003; 54(5):756-61PR

Abstract

Resting energy expenditure (REE) increases during pulmonary exacerbation by Pseudomonas aeruginosa in cystic fibrosis (CF) patients, and decreases after i.v. anti-Pseudomonas aeruginosa antibiotic therapy (IVAT). However, the impact of IVAT on total energy expenditure (TEE) is unknown. The aim of this study was to assess the changes in TEE and its main components after IVAT administered at home. Body composition measured by skinfold thickness and bio-impedance analysis, energy intake (EI) assessed by a weekly diary, REE measured by indirect calorimetry (IC), TEE assessed by a technique using 24-h heart-rate monitoring method and physical activity (PA) monitored using an activity diary (AD) were assessed in 16 patients (9 boys and 7 girls) aged 12.1 +/- 2.3 y (range, 7.1-14.6 y), before and after 28 +/- 4 d including a 14-d IVAT course. After IVAT, weight increased significantly by 1.9% (32.1 +/- 7.5 versus 32.7 +/- 7.6 kg; p < 0.05), while fat mass and fat free mass increased non significantly. EI increased by 4.6% (10,797 +/- 3039 versus 11320 +/- 3074 kJ/d; p < 0.05). TEE was not affected by IVAT (7014 +/- 1929 versus 7081 +/- 1478 kJ/d) whereas REE decreased by 4.1% (5295 +/- 909 versus 5093 +/- 837 kJ/d; p < 0.05), resulting in 9.3% increase in PA assessed by AD converted to metabolic equivalent tasks (MET) (37.0 +/- 3.1 versus 40.7 +/- 4.5 MET; p < 0.05). The improvement in nutritional status after IVAT is not related to a decrease in TEE, but probably to an increase in EI and a decrease of REE after IVAT. After IVAT, the reduction in REE is probably compensated by an increase in PA in CF patients.

Authors+Show Affiliations

Unité de Gastroentérologie, Hépatologie et Nutrition, Clinique de Pédiatrie, Hôpital Jeanne de Flandre, 2, Avenue Oscar Lambret, 59037 Lille, France; fgottrand@chru-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12904597

Citation

Béghin, Laurent, et al. "Impact of Intravenous Antibiotic Therapy On Total Daily Energy Expenditure and Physical Activity in Cystic Fibrosis Children With Pseudomonas Aeruginosa Pulmonary Exacerbation." Pediatric Research, vol. 54, no. 5, 2003, pp. 756-61.
Béghin L, Gottrand F, Michaud L, et al. Impact of intravenous antibiotic therapy on total daily energy expenditure and physical activity in cystic fibrosis children with Pseudomonas aeruginosa pulmonary exacerbation. Pediatr Res. 2003;54(5):756-61.
Béghin, L., Gottrand, F., Michaud, L., Loeuille, G. A., Wizla-Derambure, N., Sardet, A., ... Turck, D. (2003). Impact of intravenous antibiotic therapy on total daily energy expenditure and physical activity in cystic fibrosis children with Pseudomonas aeruginosa pulmonary exacerbation. Pediatric Research, 54(5), pp. 756-61.
Béghin L, et al. Impact of Intravenous Antibiotic Therapy On Total Daily Energy Expenditure and Physical Activity in Cystic Fibrosis Children With Pseudomonas Aeruginosa Pulmonary Exacerbation. Pediatr Res. 2003;54(5):756-61. PubMed PMID: 12904597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of intravenous antibiotic therapy on total daily energy expenditure and physical activity in cystic fibrosis children with Pseudomonas aeruginosa pulmonary exacerbation. AU - Béghin,Laurent, AU - Gottrand,Frédéric, AU - Michaud,Laurent, AU - Loeuille,Guy-Andre, AU - Wizla-Derambure,Nathalie, AU - Sardet,Ane, AU - Guimber,Dominique, AU - Deschildre,Antoine, AU - Turck,Dominique, Y1 - 2003/08/06/ PY - 2003/8/9/pubmed PY - 2004/7/30/medline PY - 2003/8/9/entrez SP - 756 EP - 61 JF - Pediatric research JO - Pediatr. Res. VL - 54 IS - 5 N2 - Resting energy expenditure (REE) increases during pulmonary exacerbation by Pseudomonas aeruginosa in cystic fibrosis (CF) patients, and decreases after i.v. anti-Pseudomonas aeruginosa antibiotic therapy (IVAT). However, the impact of IVAT on total energy expenditure (TEE) is unknown. The aim of this study was to assess the changes in TEE and its main components after IVAT administered at home. Body composition measured by skinfold thickness and bio-impedance analysis, energy intake (EI) assessed by a weekly diary, REE measured by indirect calorimetry (IC), TEE assessed by a technique using 24-h heart-rate monitoring method and physical activity (PA) monitored using an activity diary (AD) were assessed in 16 patients (9 boys and 7 girls) aged 12.1 +/- 2.3 y (range, 7.1-14.6 y), before and after 28 +/- 4 d including a 14-d IVAT course. After IVAT, weight increased significantly by 1.9% (32.1 +/- 7.5 versus 32.7 +/- 7.6 kg; p < 0.05), while fat mass and fat free mass increased non significantly. EI increased by 4.6% (10,797 +/- 3039 versus 11320 +/- 3074 kJ/d; p < 0.05). TEE was not affected by IVAT (7014 +/- 1929 versus 7081 +/- 1478 kJ/d) whereas REE decreased by 4.1% (5295 +/- 909 versus 5093 +/- 837 kJ/d; p < 0.05), resulting in 9.3% increase in PA assessed by AD converted to metabolic equivalent tasks (MET) (37.0 +/- 3.1 versus 40.7 +/- 4.5 MET; p < 0.05). The improvement in nutritional status after IVAT is not related to a decrease in TEE, but probably to an increase in EI and a decrease of REE after IVAT. After IVAT, the reduction in REE is probably compensated by an increase in PA in CF patients. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/12904597/Impact_of_intravenous_antibiotic_therapy_on_total_daily_energy_expenditure_and_physical_activity_in_cystic_fibrosis_children_with_Pseudomonas_aeruginosa_pulmonary_exacerbation_ L2 - http://dx.doi.org/10.1203/01.PDR.0000086020.21796.8B DB - PRIME DP - Unbound Medicine ER -