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Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study.
Acta Neuropathol. 2003 Oct; 106(4):374-82.AN

Abstract

In dementia with Lewy bodies (DLB), the Lewy bodies (LBs) are an essential substrate. Although LB pathology has gained increasing attention as one of the major causes of dementia, little is known about the exact prevalence of LB pathology in the general population. In addition, the pathology of Alzheimer-type dementia (ATD) is frequently associated with DLB. To investigate the prevalence of LB pathology in a community-based population and to evaluate the relationship between LB and ATD pathology, we performed an analysis of 102 consecutive autopsy cases. The survey extended over 2.5 years and autopsy rate was 70.5%. LB pathology was detected using alpha-synuclein immunohistochemistry and was assessed based on consensus guidelines for DLB. ATD pathology was evaluated by both CERAD and NIA-RI criteria. Twenty-nine subjects were clinically demented. LB pathology was present in 23 (22.5%) of 102 cases, and in 12 (41.4%) of the demented subjects. The LB score was not significantly different between DLB cases and non-demented subjects with LB pathology (nd-LB), while the Braak stages were significantly different between the two groups. Prevalence of LB pathology constantly increased with age. DLB cases accompanying severe ATD pathology showed more rapid increase of LB scores than did DLB cases without severe ATD pathology. Moreover, DLB cases with severe ATD pathology had poorer prognoses than those without severe ATD pathology. Our results suggested that aging and severe ATD pathology have a strong effect on the evolution of LB pathology.

Authors+Show Affiliations

Wakisaka Y
Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. w-yoshi@np.med.kyushu-u.ac.jp
Furuta A
No affiliation info available
Tanizaki Y
No affiliation info available
Kiyohara Y
No affiliation info available
Iida M
No affiliation info available
Iwaki T
No affiliation info available

MeSH

Age of OnsetAgedAged, 80 and overAgingAlzheimer DiseaseBrain StemCase-Control StudiesFemaleGyrus CinguliHumansImmunohistochemistryLewy BodiesLewy Body DiseaseMaleMental Status ScheduleNeocortexNerve Tissue ProteinsPrevalenceRisk FactorsStatistics as TopicSubstantia NigraSurvival RateSynucleinsalpha-Synuclein

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12904992

Citation

Wakisaka, Yoshinobu, et al. "Age-associated Prevalence and Risk Factors of Lewy Body Pathology in a General Population: the Hisayama Study." Acta Neuropathologica, vol. 106, no. 4, 2003, pp. 374-82.
Wakisaka Y, Furuta A, Tanizaki Y, et al. Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathol. 2003;106(4):374-82.
Wakisaka, Y., Furuta, A., Tanizaki, Y., Kiyohara, Y., Iida, M., & Iwaki, T. (2003). Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathologica, 106(4), 374-82.
Wakisaka Y, et al. Age-associated Prevalence and Risk Factors of Lewy Body Pathology in a General Population: the Hisayama Study. Acta Neuropathol. 2003;106(4):374-82. PubMed PMID: 12904992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. AU - Wakisaka,Yoshinobu, AU - Furuta,Akiko, AU - Tanizaki,Yumihiro, AU - Kiyohara,Yutaka, AU - Iida,Mitsuo, AU - Iwaki,Toru, Y1 - 2003/08/02/ PY - 2003/03/25/received PY - 2003/06/30/revised PY - 2003/06/30/accepted PY - 2003/8/9/pubmed PY - 2003/12/18/medline PY - 2003/8/9/entrez SP - 374 EP - 82 JF - Acta neuropathologica JO - Acta Neuropathol VL - 106 IS - 4 N2 - In dementia with Lewy bodies (DLB), the Lewy bodies (LBs) are an essential substrate. Although LB pathology has gained increasing attention as one of the major causes of dementia, little is known about the exact prevalence of LB pathology in the general population. In addition, the pathology of Alzheimer-type dementia (ATD) is frequently associated with DLB. To investigate the prevalence of LB pathology in a community-based population and to evaluate the relationship between LB and ATD pathology, we performed an analysis of 102 consecutive autopsy cases. The survey extended over 2.5 years and autopsy rate was 70.5%. LB pathology was detected using alpha-synuclein immunohistochemistry and was assessed based on consensus guidelines for DLB. ATD pathology was evaluated by both CERAD and NIA-RI criteria. Twenty-nine subjects were clinically demented. LB pathology was present in 23 (22.5%) of 102 cases, and in 12 (41.4%) of the demented subjects. The LB score was not significantly different between DLB cases and non-demented subjects with LB pathology (nd-LB), while the Braak stages were significantly different between the two groups. Prevalence of LB pathology constantly increased with age. DLB cases accompanying severe ATD pathology showed more rapid increase of LB scores than did DLB cases without severe ATD pathology. Moreover, DLB cases with severe ATD pathology had poorer prognoses than those without severe ATD pathology. Our results suggested that aging and severe ATD pathology have a strong effect on the evolution of LB pathology. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/12904992/Age_associated_prevalence_and_risk_factors_of_Lewy_body_pathology_in_a_general_population:_the_Hisayama_study_ DB - PRIME DP - Unbound Medicine ER -