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[Lung pathology of severe acute respiratory syndrome].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun; 25(3):360-2.ZY

Abstract

OBJECTIVE

To study the morphological features of the lungs obtained from autopsies of severe acute respiratory syndrome (SARS) patients.

METHODS

Bilateral lungs from 7 patients died from SARS were carefully studied grossly and microscopically. All tissues from these cases were routinely processed and carefully studied.

RESULTS

All lungs from these cases were extremely expanded and became solid. Microscopically, the edema and fibrin exudates in the alveoli was the most common findings, especially in the early phase of the disease. The hyaline membrane was almost always present in the lungs of these cases. The organization of intra-alveolar fibrin exudates along with the interstitial fibrosis led to obliteration of alveoli and consolidation of lungs. The desquamation and hyperplasia of alveolar lining cells was also apparent. Foci of haemorrhage and lobular pneumonia, even diffuse fungal infection were frequently seen in these specimens. Micro-thrombus were easily found in these lungs.

CONCLUSIONS

The lung of SARS from autopsy is characterized by edema, intra-alveolar fibrin exudates, hyaline membrane formation, organization of intra-alveolar exudates and fibrosis, which lead to the obliteration of alveoli and consolidation of lungs.

Authors+Show Affiliations

Department of Pathology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. chenj@csc.pumch.ac.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12905758

Citation

Chen, Jie, et al. "[Lung Pathology of Severe Acute Respiratory Syndrome]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 25, no. 3, 2003, pp. 360-2.
Chen J, Xie YQ, Zhang HT, et al. [Lung pathology of severe acute respiratory syndrome]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003;25(3):360-2.
Chen, J., Xie, Y. Q., Zhang, H. T., Wan, J. W., Wang, D. T., Lu, Z. H., Wang, Q. Z., Xue, X. H., Si, W. X., Luo, Y. F., & Qiu, H. M. (2003). [Lung pathology of severe acute respiratory syndrome]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 25(3), 360-2.
Chen J, et al. [Lung Pathology of Severe Acute Respiratory Syndrome]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003;25(3):360-2. PubMed PMID: 12905758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Lung pathology of severe acute respiratory syndrome]. AU - Chen,Jie, AU - Xie,Yong-qiang, AU - Zhang,Hong-tu, AU - Wan,Jian-wei, AU - Wang,De-tian, AU - Lu,Zhao-hui, AU - Wang,Qing-zhi, AU - Xue,Xin-hua, AU - Si,Wen-xue, AU - Luo,Yu-feng, AU - Qiu,Hong-mei, PY - 2003/8/9/pubmed PY - 2004/7/16/medline PY - 2003/8/9/entrez SP - 360 EP - 2 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 25 IS - 3 N2 - OBJECTIVE: To study the morphological features of the lungs obtained from autopsies of severe acute respiratory syndrome (SARS) patients. METHODS: Bilateral lungs from 7 patients died from SARS were carefully studied grossly and microscopically. All tissues from these cases were routinely processed and carefully studied. RESULTS: All lungs from these cases were extremely expanded and became solid. Microscopically, the edema and fibrin exudates in the alveoli was the most common findings, especially in the early phase of the disease. The hyaline membrane was almost always present in the lungs of these cases. The organization of intra-alveolar fibrin exudates along with the interstitial fibrosis led to obliteration of alveoli and consolidation of lungs. The desquamation and hyperplasia of alveolar lining cells was also apparent. Foci of haemorrhage and lobular pneumonia, even diffuse fungal infection were frequently seen in these specimens. Micro-thrombus were easily found in these lungs. CONCLUSIONS: The lung of SARS from autopsy is characterized by edema, intra-alveolar fibrin exudates, hyaline membrane formation, organization of intra-alveolar exudates and fibrosis, which lead to the obliteration of alveoli and consolidation of lungs. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/12905758/[Lung_pathology_of_severe_acute_respiratory_syndrome]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:12905758 DB - PRIME DP - Unbound Medicine ER -